Results 1 to 10 of about 10,279 (133)

Sortase A-Cleavable CD1d Identifies Sphingomyelins as Major Class of CD1d-Associated Lipids

Frontiers in Immunology, 2022
CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids and can activate natural killer T (NKT) cells through the presentation of lipid antigens.
Sebastian Zeissig, Andrej Shevchenko, Shevchenko Andrej   +2 more
exaly   +3 more sources

Zerumbone mediated CD1d inhibition suppresses epithelial to mesenchymal transition in triple negative breast cancer [PDF]

Discover Oncology
Triple-negative breast cancer (TNBC) is characterized by aggressive metastatic behavior driven through epithelial-to-mesenchymal transition (EMT). CD1d, a non-classical MHC molecule, modulates immune responses via Natural Killer T (NKT) cells and is ...
Ritis Kumar Shyanti, Sudhanshu Sharma, Mazharul Haque, Rajan Kumar Tiwari, Rajesh Singh, Manoj Mishra   +5 more
doaj   +2 more sources

CD1d functions as a ligand for PIRA2 to drive macrophage activation in nonalcoholic fatty liver disease [PDF]

Cell Death and Disease
Liver inflammation is a key driver of nonalcoholic fatty liver disease (NAFLD) and its progressive subtype, nonalcoholic steatohepatitis (NASH). Macrophages, as central players in the innate immune response, are crucial to disease pathogenesis; however ...
Xiaosheng Tan, Qingwen Li, Zhibo Ma, Lingjuan Sun, Xiangli Zhao, Jianlin Chen, Jingzeng Wang, Xiufang Weng, Li Chen, Zhishui Chen, Peixiang Lan   +10 more
doaj   +2 more sources

γδ T cell receptor recognition of CD1d in a lipid-independent manner [PDF]

Nature Communications
The monomorphic antigen-presenting molecule CD1d presents lipid antigens to both αβ and γδ T cells. While type I natural killer T cells (NKT) display exquisite specificity for CD1d presenting α-galactosylceramide (α-GalCer), the extent of lipid ...
Michael T. Rice, Sachith D. Gunasinghe, Chhon Ling Sok, Mengqi Pan, Chan-Sien Lay, Benjamin S. Gully, Jamie Rossjohn   +6 more
doaj   +2 more sources

CD1D knockout swine are permissive to African swine fever virus genotype II infection [PDF]

Emerging Microbes and Infections
African swine fever virus (ASFV) is an important pathogen of domestic and wild suids and the causative agent of African swine fever (ASF). ASFV displays a tropism for myeloid cells, predominately of the monocyte/macrophage lineage, which is critical for ...
Daniel Madden, Jessie D. Trujillo, Shanmugasundaram Elango, Isaac Fitz, Chester D. McDowell, Patricia Assato, Eulim Lyoo, Taeyong Kwon, Konner Cool, Yonghai Li, Franco Matias Ferreyra, Natasha N. Gaudreault, Igor Morozov, Kiho Lee, John Driver, Juergen A. Richt   +15 more
doaj   +2 more sources

Upregulation of CD1d and ULBP3 on B cells from healthy donors and chronic lymphocytic leukaemia patients does not prime them for killing by γδ T cells. [PDF]

PLoS ONE
Despite advances in treatment, chronic lymphocytic leukaemia (CLL) remains an incurable disease. Vδ1+ γδ T cells are reported to expand in CLL patients and to kill leukemic cells, placing them as candidates for immunotherapy.
Julie David, Amy Walsh, Ke Sin Seow, Ellen Walsh, Stefan Elekes, Rohit Upadhyay, Nawal A B Taher, Samiha Al Siyabi, Ashanty M Melo, Carmel Waldron, Elisabeth Vandenberghe, Anthony M McElligott, Derek G Doherty   +12 more
doaj   +2 more sources

Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions

Journal for ImmunoTherapy of Cancer, 2023
Background CD1d is a monomorphic major histocompatibility complex class I-like molecule that presents lipid antigens to distinct T-cell subsets and can be expressed by various malignancies.
Tanja D de Gruijl, Roeland Lameris, Jamie Rossjohn, Myrthe Veth, David Lutje Hulsik, Adam Shahine, Bart Westerman, Dale I Godfrey, Patricia Brouwer, Hans J van der Vliet   +9 more
doaj   +1 more source

CD1d facilitates African swine fever virus entry into the host cells via clathrin-mediated endocytosis

Emerging Microbes and Infections, 2023
African swine fever (ASF) is a highly contagious and acute hemorrhagic viral disease with high morbidity and mortality in domestic pigs and wild boars. The disease has become a global threat to the pig production industry and has caused enormous economic
Xin Chen, Jun Zheng, Chuanxia Liu, Tingting Li, Xiao Wang, Xuewen Li, Miaofei Bao, Jiangnan Li, Li Huang, Zhaoxia Zhang, Zhigao Bu, Changjiang Weng   +11 more
doaj   +1 more source

Multi-Omics Characterizes the Effects and Mechanisms of CD1d in Nonalcoholic Fatty Liver Disease Development

Frontiers in Cell and Developmental Biology, 2022
Nonalcoholic fatty liver disease (NAFLD) is a class of metabolic-associated liver diseases. Aberrant lipid consumption plays an important role in NAFLD pathogenesis.
Qiuxian Zheng, Chen Xue, Xinyu Gu, Dandan Shan, Qingfei Chu, Jing Wang, Haihong Zhu, Zhi Chen   +7 more
doaj   +1 more source

Steroid-mediated liver steatosis is CD1d-dependent, while steroid-induced liver necrosis, inflammation, and metabolic changes are CD1d-independent

BMC Gastroenterology, 2022
Introduction Glucocorticoids contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Natural killer T cells play a role in the pathogenesis of NAFLD and response to steroids.
Tomer Adar, Ami Ben Ya’acov, Yehudit Shabat, Meir Mizrahi, Lida Zolotarov, Yoav Lichtenstein, Yaron Ilan   +6 more
doaj   +1 more source