Results 1 to 10 of about 13,147 (200)

Sortase A-Cleavable CD1d Identifies Sphingomyelins as Major Class of CD1d-Associated Lipids

Frontiers in Immunology, 2022
CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids and can activate natural killer T (NKT) cells through the presentation of lipid antigens.
Gurdyal S Besra, Anna Shevchenko, Andrej Shevchenko   +2 more
exaly   +7 more sources

Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions [PDF]

Journal for ImmunoTherapy of Cancer, 2023
Background CD1d is a monomorphic major histocompatibility complex class I-like molecule that presents lipid antigens to distinct T-cell subsets and can be expressed by various malignancies.
Tanja D de Gruijl, Roeland Lameris, Jamie Rossjohn, Myrthe Veth, David Lutje Hulsik, Adam Shahine, Bart Westerman, Dale I Godfrey, Patricia Brouwer, Hans J van der Vliet   +9 more
doaj   +7 more sources

CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity

Experimental Dermatology, 2005
CD1d-restricted T-cells are activated by glycolipids presented by the major histocompatibility complex class-Ib molecule CD1d, found on the surface of antigen-presenting cells (APC).
Silke Gillessen, Rik J Scheper, Masaru Taniguchi   +2 more
exaly   +8 more sources

Zerumbone mediated CD1d inhibition suppresses epithelial to mesenchymal transition in triple negative breast cancer [PDF]

Discover Oncology
Triple-negative breast cancer (TNBC) is characterized by aggressive metastatic behavior driven through epithelial-to-mesenchymal transition (EMT). CD1d, a non-classical MHC molecule, modulates immune responses via Natural Killer T (NKT) cells and is ...
Ritis Kumar Shyanti, Sudhanshu Sharma, Mazharul Haque, Rajan Kumar Tiwari, Rajesh Singh, Manoj Mishra   +5 more
doaj   +2 more sources

CD1d functions as a ligand for PIRA2 to drive macrophage activation in nonalcoholic fatty liver disease [PDF]

Cell Death and Disease
Liver inflammation is a key driver of nonalcoholic fatty liver disease (NAFLD) and its progressive subtype, nonalcoholic steatohepatitis (NASH). Macrophages, as central players in the innate immune response, are crucial to disease pathogenesis; however ...
Xiaosheng Tan, Qingwen Li, Zhibo Ma, Lingjuan Sun, Xiangli Zhao, Jianlin Chen, Jingzeng Wang, Xiufang Weng, Li Chen, Zhishui Chen, Peixiang Lan   +10 more
doaj   +2 more sources

γδ T cell receptor recognition of CD1d in a lipid-independent manner [PDF]

Nature Communications
The monomorphic antigen-presenting molecule CD1d presents lipid antigens to both αβ and γδ T cells. While type I natural killer T cells (NKT) display exquisite specificity for CD1d presenting α-galactosylceramide (α-GalCer), the extent of lipid ...
Michael T. Rice, Sachith D. Gunasinghe, Chhon Ling Sok, Mengqi Pan, Chan-Sien Lay, Benjamin S. Gully, Jamie Rossjohn   +6 more
doaj   +2 more sources

CD1d knockout swine are permissive to African swine fever virus genotype II infection [PDF]

Emerging Microbes and Infections
African swine fever virus (ASFV) is an important pathogen of domestic and wild suids and the causative agent of African swine fever (ASF). ASFV displays a tropism for myeloid cells, predominately of the monocyte/macrophage lineage, which is critical for ...
Daniel Madden, Jessie D. Trujillo, Shanmugasundaram Elango, Isaac Fitz, Chester D. McDowell, Patricia Assato, Eulim Lyoo, Taeyong Kwon, Konner Cool, Yonghai Li, Franco Matias Ferreyra, Natasha N. Gaudreault, Igor Morozov, Kiho Lee, John Driver, Juergen A. Richt   +15 more
doaj   +2 more sources

Upregulation of CD1d and ULBP3 on B cells from healthy donors and chronic lymphocytic leukaemia patients does not prime them for killing by γδ T cells. [PDF]

PLoS ONE
Despite advances in treatment, chronic lymphocytic leukaemia (CLL) remains an incurable disease. Vδ1+ γδ T cells are reported to expand in CLL patients and to kill leukemic cells, placing them as candidates for immunotherapy.
Julie David, Amy Walsh, Ke Sin Seow, Ellen Walsh, Stefan Elekes, Rohit Upadhyay, Nawal A B Taher, Samiha Al Siyabi, Ashanty M Melo, Carmel Waldron, Elisabeth Vandenberghe, Anthony M McElligott, Derek G Doherty   +12 more
doaj   +2 more sources

Structure-Function Implications of the Ability of Monoclonal Antibodies Against α-Galactosylceramide-CD1d Complex to Recognize β-Mannosylceramide Presentation by CD1d

Frontiers in Immunology, 2019
iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with similar structures induces robust proliferation and cytokine production of iNKT cells and ...
Katharine Clark, Jessica Yau, Anja Bloom, Jing Wang, David J. Venzon, Motoshi Suzuki, Lise Pasquet, Benjamin J. Compton, Susanna L. Cardell, Steven A. Porcelli, Gavin F. Painter, Dirk M. Zajonc, Dirk M. Zajonc, Jay A. Berzofsky, Masaki Terabe   +14 more
doaj   +2 more sources

Adoptive immunotherapy mediated by ex vivo expanded natural killer T cells against CD1d-expressing lymphoid neoplasms

Haematologica, 2009
Background CD1d is a monomorphic antigen presentation molecule expressed in several hematologic malignancies. Alpha-galactosylceramide (α-GalCer) is a glycolipid that can be presented to cytotoxic CD1d-restricted T cells.
Davide Bagnara, Adalberto Ibatici, Mirko Corselli, Nadia Sessarego, Claudya Tenca, Amleto De Santanna, Andrea Mazzarello, Antonio Daga, Renzo Corvò, Giulio De Rossi, Francesco Frassoni, Ermanno Ciccone, Franco Fais   +12 more
doaj   +2 more sources