Results 1 to 10 of about 14,032 (192)

Sortase A-Cleavable CD1d Identifies Sphingomyelins as Major Class of CD1d-Associated Lipids

Frontiers in Immunology, 2022
CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids and can activate natural killer T (NKT) cells through the presentation of lipid antigens.
Sebastian Zeissig, Andrej Shevchenko
exaly   +7 more sources

Analysis of the Role of N-Linked Glycans on Human CD1d Molecules. [PDF]

Cell Biochem Funct
ABSTRACT CD1d is a cell‐surface expressed glycoprotein that presents a variety of lipid and glycolipid antigens to invariant natural killer T‐cells (iNKT). We have examined the role of the N‐linked glycans on the human CD1d (hCD1d) in modulating the responses of iNKT cells using a combination of cell‐free, cell‐based assays and in silico analyses ...
Bandyopadhyay S, Pradhan S.
europepmc   +2 more sources

Identifying Co-Expressed lncRNAs Correlated With Traits of Interest in an Animal Model for Metabolic Diseases in Humans. [PDF]

Anim Genet
ABSTRACT Nutrigenomics investigates how nutrients modulate gene expression. Among them, fatty acids (FA) play important roles in regulating gene transcription, while long non‐coding RNAs (lncRNAs) may be associated with gene regulation and metabolic diseases.
Nascimento LE, da Silva BPM, de Oliveira CS, Durval MC, Freitas FAO, Ciconello FN, Gervásio IC, Fanalli SL, de Souza Fonseca PA, Gutiérrez-Gil B, de Almeida VV, Cesar ASM.   +11 more
europepmc   +2 more sources

Hematopoietic Antigen Presenting Cells Fine-Tune the Effector Phenotype of Intrathymic Unconventional αβ T Cells. [PDF]

Eur J Immunol
Our study describes how the effector maturation of intrathymic iNKT and MAIT cells is guided by distinct hematopoietic APCs: DC1s for iNKT cells and macrophages for MAIT cells. ABSTRACT The development of unconventional αβ T cells, including invariant natural killer T (iNKT) and mucosal‐associated invariant T (MAIT) cells, in the thymus is distinct ...
Wang Y, Lam TT, Ochiai S, Larson AR, Matthews DB, McWilliam HEG, Kaisho T, Lahoud MH, Villadangos JA, Diehl GE, Ronchese F, Pellicci DG, Chong MMW.   +12 more
europepmc   +2 more sources

CD1d functions as a ligand for PIRA2 to drive macrophage activation in nonalcoholic fatty liver disease [PDF]

Cell Death and Disease
Liver inflammation is a key driver of nonalcoholic fatty liver disease (NAFLD) and its progressive subtype, nonalcoholic steatohepatitis (NASH). Macrophages, as central players in the innate immune response, are crucial to disease pathogenesis; however ...
Xiaosheng Tan, Qingwen Li, Zhibo Ma, Lingjuan Sun, Xiangli Zhao, Jianlin Chen, Jingzeng Wang, Xiufang Weng, Li Chen, Zhishui Chen, Peixiang Lan   +10 more
doaj   +2 more sources

CD1D knockout swine are permissive to African swine fever virus genotype II infection [PDF]

Emerging Microbes and Infections
African swine fever virus (ASFV) is an important pathogen of domestic and wild suids and the causative agent of African swine fever (ASF). ASFV displays a tropism for myeloid cells, predominately of the monocyte/macrophage lineage, which is critical for ...
Daniel Madden, Jessie D. Trujillo, Shanmugasundaram Elango, Isaac Fitz, Chester D. McDowell, Patricia Assato, Eulim Lyoo, Taeyong Kwon, Konner Cool, Yonghai Li, Franco Matias Ferreyra, Natasha N. Gaudreault, Igor Morozov, Kiho Lee, John Driver, Juergen A. Richt   +15 more
doaj   +2 more sources

Zerumbone mediated CD1d inhibition suppresses epithelial to mesenchymal transition in triple negative breast cancer [PDF]

Discover Oncology
Triple-negative breast cancer (TNBC) is characterized by aggressive metastatic behavior driven through epithelial-to-mesenchymal transition (EMT). CD1d, a non-classical MHC molecule, modulates immune responses via Natural Killer T (NKT) cells and is ...
Ritis Kumar Shyanti, Sudhanshu Sharma, Mazharul Haque, Rajan Kumar Tiwari, Rajesh Singh, Manoj Mishra   +5 more
doaj   +2 more sources

γδ T cell receptor recognition of CD1d in a lipid-independent manner [PDF]

Nature Communications
The monomorphic antigen-presenting molecule CD1d presents lipid antigens to both αβ and γδ T cells. While type I natural killer T cells (NKT) display exquisite specificity for CD1d presenting α-galactosylceramide (α-GalCer), the extent of lipid ...
Michael T. Rice, Sachith D. Gunasinghe, Chhon Ling Sok, Mengqi Pan, Chan-Sien Lay, Benjamin S. Gully, Jamie Rossjohn   +6 more
doaj   +2 more sources

Upregulation of CD1d and ULBP3 on B cells from healthy donors and chronic lymphocytic leukaemia patients does not prime them for killing by γδ T cells. [PDF]

PLoS ONE
Despite advances in treatment, chronic lymphocytic leukaemia (CLL) remains an incurable disease. Vδ1+ γδ T cells are reported to expand in CLL patients and to kill leukemic cells, placing them as candidates for immunotherapy.
Julie David, Amy Walsh, Ke Sin Seow, Ellen Walsh, Stefan Elekes, Rohit Upadhyay, Nawal A B Taher, Samiha Al Siyabi, Ashanty M Melo, Carmel Waldron, Elisabeth Vandenberghe, Anthony M McElligott, Derek G Doherty   +12 more
doaj   +2 more sources

The Dual Roles of Regulatory B Cells in Infection, Cancer, and Immunity. [PDF]

MedComm (2020)
Regulatory B cells maintain immune homeostasis via suppressive cytokines and surface molecules like PD‐L1. While beneficially suppressing autoimmunity and promoting transplant tolerance, these identical mechanisms detrimentally attenuate antipathogen and antitumor immune responses.
Feng A, Li Q, Jiang N, Chen Q.
europepmc   +2 more sources