Results 31 to 40 of about 10,329 (179)
CD1d-lipid antigen recognition by the γδ TCR [PDF]
Nature Immunology, 2013 The T lymphocytes repertoire is divided into two major lineages, αβ and γδ T cells, which are defined by their T cell receptor (TCR) gene-segment usage. To date, the key discoveries on human CD1d restricted T cells have focussed on the type I Natural Killer T cells (NKT) subset that express an invariant TCR α chain (Vα24Jα18) which pairs with a β chain
Uldrich, AP +10 more
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Frontiers in Immunology, 2015 Natural killer T (NKT) cells comprise a family of specialized T cells that recognize lipid antigens presented by CD1d. Based on their T cell receptor (TCR) usage and antigen-specificities, CD1d-restricted NKT cells have been divided into two main subsets:
Elodie eMacho-Fernandez, Manfred eBrigl
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Frontiers in Medicine, 2022 Invariant Natural Killer T (iNKT) cells are T lymphocytes expressing a conserved semi-invariant TCR specific for lipid antigens (Ags) restricted for the monomorphic MHC class I-related molecule CD1d.
Gloria Delfanti +4 more
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CD1d Endosomal Trafficking Is Independently Regulated by an Intrinsic CD1d-Encoded Tyrosine Motif and by the Invariant Chain [PDF]
Immunity, 2001 Endosomal trafficking is an essential component of the CD1 pathway of lipid antigen presentation to T cells. We demonstrate that CD1d access to endosomal compartments is under dual regulation by an intrinsic tyrosine-based motif, which governs intense recycling between the plasma membrane and the endosome, and by the invariant chain, with which CD1d ...
Jayawardena-Wolf, Jayanthi +4 more
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iNKT Cells Suppress Pathogenic NK1.1+CD8+ T Cells in DSS-Induced Colitis
Frontiers in Immunology, 2018 T cells producing IFNγ play a pathogenic role in the development of inflammatory bowel disease (IBD). To investigate the functions of CD1d-dependent invariant natural killer T (iNKT) cells in experimental colitis induced in Yeti mice with dysregulated ...
Sung Won Lee +5 more
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Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells. [PDF]
PLoS Biology, 2011 Invariant natural killer T (iNKT) cells are an evolutionary conserved T cell population characterized by features of both the innate and adaptive immune response.
Enrico Girardi +9 more
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Biochemistry and Biophysics Reports, 2020 Norovirus infection cause epidemic nonbacterial gastroenteritis in patients. The immune mechanisms responsible for the clearance of virus are not completely understood. We examined whether NKT cells are effective against norovirus infection using CD1d KO
Hiroki Ishikawa +7 more
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Functionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining [PDF]
The Journal of Experimental Medicine, 2002 CD1d-restricted natural killer (NK)T cells are known to potently secrete T helper (Th)1 and Th2 cytokines and to mediate cytolysis, but it is unclear how these contrasting functional activities are regulated. Using lipid antigen–loaded CD1d tetramers, we have distinguished two subsets of CD1d-restricted T cells in fresh peripheral blood that differ in ...
Gumperz, Jenny E. +3 more
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Neurofibromin 1 Impairs Natural Killer T-Cell-Dependent Antitumor Immunity against a T-Cell Lymphoma
Frontiers in Immunology, 2018 Neurofibromin 1 (NF1) is a tumor suppressor gene encoding a Ras GTPase that negatively regulates Ras signaling pathways. Mutations in NF1 are linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome.
Jianyun Liu +6 more
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Simplexide induces CD1d-dependent cytokine and chemokine production from human monocytes. [PDF]
PLoS ONE, 2014 Monocytes are major effector cells of innate immunity and recognize several endogenous and exogenous molecules due to the expression of wide spectrum of receptors.
Stefania Loffredo +9 more
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