Results 31 to 40 of about 14,032 (192)
OncoImmunology, 2018 Immunotherapies that target CD1d-restricted invariant NKT (iNKT) cells can prevent tumor growth in murine models but trials in humans have shown limited clinical efficacy. Here, we show that iNKT cells are depleted from blood and bronchial lavage samples
Éilis Dockry +6 more
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Come forth CD1d: Hsp110 in the regulation of intestinal epithelial CD1d expression [PDF]
Journal of Clinical Investigation, 2003 CD1d, a nonclassical MHC class I-like molecule, is prominently expressed on intestinal epithelial cells and is thought to function in the regulation of intestinal intraepithelial lymphocyte activity. Hsp110, an abundant heat shock protein present in essentially all mammalian tissues, has now been shown to upregulate CD1d expression in colonic tissue ...
openaire +2 more sources
Crystal structures of bovine CD1d reveal altered αGalCer presentation and a restricted A' pocket unable to bind long-chain glycolipids. [PDF]
PLoS ONE, 2012 NKT cells play important roles in immune surveillance. They rapidly respond to pathogens by detecting microbial glycolipids when presented by the non-classical MHC I homolog CD1d. Previously, ruminants were considered to lack NKT cells due to the lack of
Jing Wang +5 more
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, 2022 CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids and can activate natural killer T (NKT) cells through the presentation of lipid antigens.
Maren Rudolph (11726318) +9 more
core +1 more source
PLoS ONE, 2010 BackgroundCD1d is a nonpolymorphic MHC class I-like molecule which presents nonpeptide ligands, e.g. glycolipids, to NKT cells. These cells are known to have multiple effects on innate and adaptive immune responses and on the development of pathological ...
Elisa Monzon-Casanova +11 more
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CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides
Frontiers in Immunology, 2018 NKT cells belong to a distinct subset of T cells that recognize hydrophobic antigens presented by major histocompatibility complex class I-like molecules, such as CD1d.
Yusuke Nishioka +3 more
doaj +1 more source
, 2022 CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids and can activate natural killer T (NKT) cells through the presentation of lipid antigens.
Maren Rudolph (11726318) +9 more
core +1 more source
, 2022 CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids and can activate natural killer T (NKT) cells through the presentation of lipid antigens.
Maren Rudolph (11726318) +9 more
core +1 more source
Overexpression of CD1d by Keratinocytes in Psoriasis and CD1d-Dependent IFN-γ Production by NK-T Cells [PDF]
The Journal of Immunology, 2000 Abstract The MHC class I-like protein CD1d is a nonpolymorphic molecule that plays a central role in development and activation of a subset of T cells that coexpress receptors used by NK cells (NK-T cells). Recently, T cells bearing NK receptors were identified in acute and chronic lesions of psoriasis. To determine whether NK-T cells
B, Bonish +7 more
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Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis [PDF]
, 2009 Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis Background: The role of cytotoxicity of NKT-cells in the skin is not defined. There are two prototypic skin diseases in which epidermal Keratinocytes (KC) over-express CD1d, a
Balato, Anna
core +1 more source