Results 31 to 40 of about 13,147 (200)
, 2022 CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids and can activate natural killer T (NKT) cells through the presentation of lipid antigens.
Maren Rudolph (11726318) +9 more
core +1 more source
Come forth CD1d: Hsp110 in the regulation of intestinal epithelial CD1d expression [PDF]
Journal of Clinical Investigation, 2003 CD1d, a nonclassical MHC class I-like molecule, is prominently expressed on intestinal epithelial cells and is thought to function in the regulation of intestinal intraepithelial lymphocyte activity. Hsp110, an abundant heat shock protein present in essentially all mammalian tissues, has now been shown to upregulate CD1d expression in colonic tissue ...
openaire +2 more sources
OncoImmunology, 2018 Immunotherapies that target CD1d-restricted invariant NKT (iNKT) cells can prevent tumor growth in murine models but trials in humans have shown limited clinical efficacy. Here, we show that iNKT cells are depleted from blood and bronchial lavage samples
Éilis Dockry +6 more
doaj +1 more source
, 2022 CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids and can activate natural killer T (NKT) cells through the presentation of lipid antigens.
Maren Rudolph (11726318) +9 more
core +1 more source
A potent adjuvant effect of a CD1d-binding NKT cell ligand in human immune system mice
Expert Review of Vaccines, 2017 Objectives: A CD1d-binding invariant natural killer T (iNKT)-cell stimulatory glycolipid, namely 7DW8-5, is shown to enhance the efficacy of radiation-attenuated sporozoites (RAS)-based malaria vaccine in mice.
Xiangming Li +6 more
doaj +1 more source
Nonclassical MHC-I Molecules: Emerging Therapeutic Targets in Next-Generation Immunotherapy. [PDF]
MedComm (2020)Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
He W, McMichael AJ.
europepmc +2 more sources
, 2022 CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids and can activate natural killer T (NKT) cells through the presentation of lipid antigens.
Maren Rudolph (11726318) +9 more
core +1 more source
CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides
Frontiers in Immunology, 2018 NKT cells belong to a distinct subset of T cells that recognize hydrophobic antigens presented by major histocompatibility complex class I-like molecules, such as CD1d.
Yusuke Nishioka +3 more
doaj +1 more source
Mixed Signals: T Cells as Architects of IgE Immunity. [PDF]
Immunol RevABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Tierney AL +3 more
europepmc +2 more sources
Polymorphisms in the CD1d Promoter That Regulate CD1d Gene Expression Are Associated with Impaired NKT Cell Development [PDF]
The Journal of Immunology, 2014 Abstract CD1d-restricted NKT cells comprise an innate-like T cell population that exerts significant influence over early events in the developing immune response. The frequency of NKT cells is highly variable in humans and in mice, but the basis for this variability remains unclear. In this study, we report a striking deficiency of type
Zachary D, Borg +7 more
openaire +2 more sources