Results 51 to 60 of about 20,572 (218)
TGFβ Inhibits CD1d Expression on Dendritic Cells [PDF]
Journal of Investigative Dermatology, 2005 The CD1 family of cell surface glycoprotein has been demonstrated to be a third lineage of antigen-presenting molecules for specific T cell responses. They present lipidic, glycolipidic antigen and hydrophobic peptide to T cells. CD1d restricted T cells play a role in autoimmune disease and in tumor immunity.
Ronger-Savle, S. +7 more
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Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop.
PLoS Biology, 2010 Invariant Natural Killer T cells (iNKT) are a versatile lymphocyte subset with important roles in both host defense and immunological tolerance. They express a highly conserved TCR which mediates recognition of the non-polymorphic, lipid-binding molecule
Gediminas Matulis +9 more
doaj +1 more source
Overexpression of CD1d by Keratinocytes in Psoriasis and CD1d-Dependent IFN-γ Production by NK-T Cells [PDF]
The Journal of Immunology, 2000 Abstract The MHC class I-like protein CD1d is a nonpolymorphic molecule that plays a central role in development and activation of a subset of T cells that coexpress receptors used by NK cells (NK-T cells). Recently, T cells bearing NK receptors were identified in acute and chronic lesions of psoriasis.
B, Bonish +7 more
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CD1d-dependent CLL progression? [PDF]
Blood, 2017 In this issue of Blood , Gorini et al provide compelling evidence for an indirect CD1d- and natural killer T (NKT) cell–dependent mechanism that promotes disease progression in chronic lymphocytic leukemia (CLL ...
openaire +2 more sources
The molecular basis for recognition of CD1d/α-galactosylceramide by a human non-Vα24 T cell receptor. [PDF]
PLoS Biology, 2012 CD1d-mediated presentation of glycolipid antigens to T cells is capable of initiating powerful immune responses that can have a beneficial impact on many diseases.
Jacinto López-Sagaseta +4 more
doaj +1 more source
Hepatic CD1d Expression in Hepatitis C Virus Infection and Recognition by Resident Proinflammatory CD1d-Reactive T Cells [PDF]
The Journal of Immunology, 2004 Abstract A subset of CD161+CD56+/− NKT cells can recognize glycolipids presented by CD1d and positively or negatively regulate inflammatory responses, including those implicated in several models of hepatitis. CD1d is expressed at very low levels in the healthy liver, but there is a large fraction of CD161+CD56+ NKT cells. There are high
DURANTE MANGONI, Emanuele +7 more
openaire +4 more sources
Frontiers in Immunology, 2015 Natural killer T (NKT) cells comprise a family of specialized T cells that recognize lipid antigens presented by CD1d. Based on their T cell receptor (TCR) usage and antigen-specificities, CD1d-restricted NKT cells have been divided into two main subsets:
Elodie eMacho-Fernandez, Manfred eBrigl
doaj +1 more source
Frontiers in Medicine, 2022 Invariant Natural Killer T (iNKT) cells are T lymphocytes expressing a conserved semi-invariant TCR specific for lipid antigens (Ags) restricted for the monomorphic MHC class I-related molecule CD1d.
Gloria Delfanti +4 more
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Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing γδT Cells [PDF]
, 2017 Reactive arthritis (ReA) is an inflammatory condition of the joints that arises following an infection. Salmonella enterocolitis is one of the most common infections leading to ReA.
Aya Castañeda, Maria del Rosario +6 more
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iNKT Cells Suppress Pathogenic NK1.1+CD8+ T Cells in DSS-Induced Colitis
Frontiers in Immunology, 2018 T cells producing IFNγ play a pathogenic role in the development of inflammatory bowel disease (IBD). To investigate the functions of CD1d-dependent invariant natural killer T (iNKT) cells in experimental colitis induced in Yeti mice with dysregulated ...
Sung Won Lee +5 more
doaj +1 more source