Results 51 to 60 of about 13,147 (200)

iNKT Cells Suppress Pathogenic NK1.1+CD8+ T Cells in DSS-Induced Colitis

Frontiers in Immunology, 2018
T cells producing IFNγ play a pathogenic role in the development of inflammatory bowel disease (IBD). To investigate the functions of CD1d-dependent invariant natural killer T (iNKT) cells in experimental colitis induced in Yeti mice with dysregulated ...
Sung Won Lee, Hyun Jung Park, Jae Hee Cheon, Lan Wu, Luc Van Kaer, Seokmann Hong   +5 more
doaj   +1 more source

Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells. [PDF]

PLoS Biology, 2011
Invariant natural killer T (iNKT) cells are an evolutionary conserved T cell population characterized by features of both the innate and adaptive immune response.
Enrico Girardi, Esther Dawen Yu, Yali Li, Norihito Tarumoto, Bo Pei, Jing Wang, Petr Illarionov, Yuki Kinjo, Mitchell Kronenberg, Dirk M Zajonc   +9 more
doaj   +1 more source

CD1d Ligands: The Good, the Bad, and the Ugly [PDF]

The Journal of Immunology, 2006
Abstract The MHC class I-like CD1d glycoprotein is a member of the CD1 family of Ag-presenting molecules and is responsible for the selection of NKT cells. A number of ligands that can be presented by CD1d to NKT or other CD1d-restricted T cells have been identified.
openaire   +2 more sources

CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway

Open Medicine
The study aimed to investigate the effect of CD1d down-regulation on the proliferation, migration, and apoptosis of papillary thyroid carcinoma cells and explore the underlying mechanism.
Liu Qingyuan, Zhai Tong, Ma Lei, Liu Qilun   +3 more
doaj   +1 more source

NKT cells are responsible for the clearance of murine norovirus through the virus-specific secretory IgA pathway

Biochemistry and Biophysics Reports, 2020
Norovirus infection cause epidemic nonbacterial gastroenteritis in patients. The immune mechanisms responsible for the clearance of virus are not completely understood. We examined whether NKT cells are effective against norovirus infection using CD1d KO
Hiroki Ishikawa, Satoshi Ino, Toshiko Yamochi, Hiraku Sasaki, Takahiro Kobayashi, Chikara Kohda, Masafumi Takimoto, Kazuo Tanaka   +7 more
doaj   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Functionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining [PDF]

The Journal of Experimental Medicine, 2002
CD1d-restricted natural killer (NK)T cells are known to potently secrete T helper (Th)1 and Th2 cytokines and to mediate cytolysis, but it is unclear how these contrasting functional activities are regulated. Using lipid antigen–loaded CD1d tetramers, we have distinguished two subsets of CD1d-restricted T cells in fresh peripheral blood that differ in ...
Gumperz, Jenny E., Miyake, Sachiko, Yamamura, Takashi, Brenner, Michael B.   +3 more
openaire   +2 more sources

Neurofibromin 1 Impairs Natural Killer T-Cell-Dependent Antitumor Immunity against a T-Cell Lymphoma

Frontiers in Immunology, 2018
Neurofibromin 1 (NF1) is a tumor suppressor gene encoding a Ras GTPase that negatively regulates Ras signaling pathways. Mutations in NF1 are linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome.
Jianyun Liu, Richard M. Gallo, Masood A. Khan, Masood A. Khan, Gourapura J. Renukaradhya, Gourapura J. Renukaradhya, Randy R. Brutkiewicz   +6 more
doaj   +1 more source

Simplexide induces CD1d-dependent cytokine and chemokine production from human monocytes. [PDF]

PLoS ONE, 2014
Monocytes are major effector cells of innate immunity and recognize several endogenous and exogenous molecules due to the expression of wide spectrum of receptors.
Stefania Loffredo, Rosaria I Staiano, Francescopaolo Granata, Valeria Costantino, Francesco Borriello, Annunziata Frattini, Maria Teresa Lepore, Alfonso Mangoni, Gianni Marone, Massimo Triggiani   +9 more
doaj   +1 more source

Epigenetic control of CD1D expression as a mechanism of resistance to immune checkpoint therapy in poorly immunogenic melanomas

Frontiers in Immunology, 2023
Immune Checkpoint Therapies (ICT) have revolutionized the treatment of metastatic melanoma. However, only a subset of patients reaches complete responses. Deficient β2-microglobulin (β2M) expression impacts antigen presentation to T cells, leading to ICT
Mona Meng Wang, Mona Meng Wang, Saara A. Koskela, Arfa Mehmood, Miriam Langguth, Eleftheria Maranou, Carlos R. Figueiredo, Carlos R. Figueiredo   +7 more
doaj   +1 more source