Results 51 to 60 of about 14,498 (196)

Simplexide induces CD1d-dependent cytokine and chemokine production from human monocytes. [PDF]

PLoS ONE, 2014
Monocytes are major effector cells of innate immunity and recognize several endogenous and exogenous molecules due to the expression of wide spectrum of receptors.
Stefania Loffredo, Rosaria I Staiano, Francescopaolo Granata, Valeria Costantino, Francesco Borriello, Annunziata Frattini, Maria Teresa Lepore, Alfonso Mangoni, Gianni Marone, Massimo Triggiani   +9 more
doaj   +1 more source

Epigenetic control of CD1D expression as a mechanism of resistance to immune checkpoint therapy in poorly immunogenic melanomas

Frontiers in Immunology, 2023
Immune Checkpoint Therapies (ICT) have revolutionized the treatment of metastatic melanoma. However, only a subset of patients reaches complete responses. Deficient β2-microglobulin (β2M) expression impacts antigen presentation to T cells, leading to ICT
Mona Meng Wang, Mona Meng Wang, Saara A. Koskela, Arfa Mehmood, Miriam Langguth, Eleftheria Maranou, Carlos R. Figueiredo, Carlos R. Figueiredo   +7 more
doaj   +1 more source

Extended routine lymphocyte immunophenotyping refines individual immune organization across a heterogeneous patient cohort

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Routine TBNK immunophenotyping detects the major lymphocyte compartments but may underestimate the biologically relevant variation contributed by less frequent but well‐defined minor lymphocyte subsets. This study evaluated whether extending routine TBNK immunophenotyping with minor lymphocyte subsets provides complementary, analytically ...
Carlos Agustin Villegas Valverde, Yendry Ventura Carmenate, Vianed Marsan Suarez, Yandy Marx Castillo Aleman, Imilla Casado Hernandez, Rachely Hernandez Corrales   +5 more
wiley   +1 more source

CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway

Open Medicine
The study aimed to investigate the effect of CD1d down-regulation on the proliferation, migration, and apoptosis of papillary thyroid carcinoma cells and explore the underlying mechanism.
Liu Qingyuan, Zhai Tong, Ma Lei, Liu Qilun   +3 more
doaj   +1 more source

Increased anergic B cells and decreased antibody‐secreting cells during romiplostim treatment in patients with immune thrombocytopenia

British Journal of Haematology, EarlyView.
Summary Patients with immune thrombocytopenia (ITP) exhibit substantial heterogeneity in treatment responses. Approximately 30%–50% of patients maintain remission after discontinuation of thrombopoietin receptor agonists (TPO‐RA), suggesting immunomodulatory effects beyond enhanced thrombopoiesis.
Vivianne S. Nelson, Rebeca Gutiérrez‐Cózar, Rebecca Cornelis, S. Marieke van Ham, Anja ten Brinke, Rick Kapur   +5 more
wiley   +1 more source

CD1d Ligands: The Good, the Bad, and the Ugly [PDF]

The Journal of Immunology, 2006
Abstract The MHC class I-like CD1d glycoprotein is a member of the CD1 family of Ag-presenting molecules and is responsible for the selection of NKT cells. A number of ligands that can be presented by CD1d to NKT or other CD1d-restricted T cells have been identified.
openaire   +2 more sources

CD1d- and MR1-Restricted T Cells in Sepsis [PDF]

Frontiers in Immunology, 2015
Dysregulated immune responses to infection, such as those encountered in sepsis, can be catastrophic. Sepsis is typically triggered by an overwhelming systemic response to an infectious agent(s) and is associated with high morbidity and mortality even under optimal critical care. Recent studies have implicated unconventional, innate-like T lymphocytes,
Peter A. Szabo, Ram V. Anantha, Ram V. Anantha, Christopher R. Shaler, John K. McCormick, S.M. Mansour eHaeryfar, S.M. Mansour eHaeryfar   +6 more
openaire   +3 more sources

Alternative spliced CD1d transcripts in human bronchial epithelial cells.

PLoS ONE, 2011
CD1d is a MHC I like molecule which presents glycolipid to natural killer T (NKT) cells, a group of cells with diverse but critical immune regulatory functions in the immune system.
Kambez Hajipouran Benam, Wai Ling Kok, Andrew J McMichael, Ling-Pei Ho   +3 more
doaj   +1 more source

The Leukocyte Landscape Across Mouse Strains and Tissues

Immunology &Cell Biology, EarlyView.
The blood, bone marrow, liver, lymph nodes, and spleen of naïve male mice contained unique immunobiomes which differed between commonly used strains. BALB‐derived strains exhibited helper‐ and innate‐biased immune profiles, C57BL/6J‐derived strains were enriched for cytotoxic and immune surveillance populations, and DBA/2 J mice displayed elevated γδ T
Ella Trolio, Sarah Dart, Liu Liu, Michaela Lucas, Amy Prosser   +4 more
wiley   +1 more source

Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors.

PLoS ONE, 2016
Invariant natural killer T (iNKT) cells recognize self-lipids presented by CD1d through characteristic TCRs, which mainly consist of the invariant Vα14-Jα18 TCRα chain and Vβ8.2, 7 or 2 TCRβ chains with hypervariable CDR3β sequences in mice.
Tingxi Guo, Kenji Chamoto, Munehide Nakatsugawa, Toshiki Ochi, Yuki Yamashita, Mark Anczurowski, Marcus O Butler, Naoto Hirano   +7 more
doaj   +1 more source