Results 51 to 60 of about 14,032 (192)

NKT cells are responsible for the clearance of murine norovirus through the virus-specific secretory IgA pathway

Biochemistry and Biophysics Reports, 2020
Norovirus infection cause epidemic nonbacterial gastroenteritis in patients. The immune mechanisms responsible for the clearance of virus are not completely understood. We examined whether NKT cells are effective against norovirus infection using CD1d KO
Hiroki Ishikawa, Satoshi Ino, Toshiko Yamochi, Hiraku Sasaki, Takahiro Kobayashi, Chikara Kohda, Masafumi Takimoto, Kazuo Tanaka   +7 more
doaj   +1 more source

Simplexide induces CD1d-dependent cytokine and chemokine production from human monocytes. [PDF]

PLoS ONE, 2014
Monocytes are major effector cells of innate immunity and recognize several endogenous and exogenous molecules due to the expression of wide spectrum of receptors.
Stefania Loffredo, Rosaria I Staiano, Francescopaolo Granata, Valeria Costantino, Francesco Borriello, Annunziata Frattini, Maria Teresa Lepore, Alfonso Mangoni, Gianni Marone, Massimo Triggiani   +9 more
doaj   +1 more source

CD1d Endosomal Trafficking Is Independently Regulated by an Intrinsic CD1d-Encoded Tyrosine Motif and by the Invariant Chain [PDF]

Immunity, 2001
Endosomal trafficking is an essential component of the CD1 pathway of lipid antigen presentation to T cells. We demonstrate that CD1d access to endosomal compartments is under dual regulation by an intrinsic tyrosine-based motif, which governs intense recycling between the plasma membrane and the endosome, and by the invariant chain, with which CD1d ...
Jayawardena-Wolf, Jayanthi, Benlagha, Kamel, Chiu, Ya-Hui, Mehr, Ramit, Bendelac, Albert   +4 more
openaire   +2 more sources

Neurofibromin 1 Impairs Natural Killer T-Cell-Dependent Antitumor Immunity against a T-Cell Lymphoma

Frontiers in Immunology, 2018
Neurofibromin 1 (NF1) is a tumor suppressor gene encoding a Ras GTPase that negatively regulates Ras signaling pathways. Mutations in NF1 are linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome.
Jianyun Liu, Richard M. Gallo, Masood A. Khan, Masood A. Khan, Gourapura J. Renukaradhya, Gourapura J. Renukaradhya, Randy R. Brutkiewicz   +6 more
doaj   +1 more source

Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells. [PDF]

PLoS Biology, 2011
Invariant natural killer T (iNKT) cells are an evolutionary conserved T cell population characterized by features of both the innate and adaptive immune response.
Enrico Girardi, Esther Dawen Yu, Yali Li, Norihito Tarumoto, Bo Pei, Jing Wang, Petr Illarionov, Yuki Kinjo, Mitchell Kronenberg, Dirk M Zajonc   +9 more
doaj   +1 more source

Epigenetic control of CD1D expression as a mechanism of resistance to immune checkpoint therapy in poorly immunogenic melanomas

Frontiers in Immunology, 2023
Immune Checkpoint Therapies (ICT) have revolutionized the treatment of metastatic melanoma. However, only a subset of patients reaches complete responses. Deficient β2-microglobulin (β2M) expression impacts antigen presentation to T cells, leading to ICT
Mona Meng Wang, Mona Meng Wang, Saara A. Koskela, Arfa Mehmood, Miriam Langguth, Eleftheria Maranou, Carlos R. Figueiredo, Carlos R. Figueiredo   +7 more
doaj   +1 more source

Extended routine lymphocyte immunophenotyping refines individual immune organization across a heterogeneous patient cohort

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Routine TBNK immunophenotyping detects the major lymphocyte compartments but may underestimate the biologically relevant variation contributed by less frequent but well‐defined minor lymphocyte subsets. This study evaluated whether extending routine TBNK immunophenotyping with minor lymphocyte subsets provides complementary, analytically ...
Carlos Agustin Villegas Valverde, Yendry Ventura Carmenate, Vianed Marsan Suarez, Yandy Marx Castillo Aleman, Imilla Casado Hernandez, Rachely Hernandez Corrales   +5 more
wiley   +1 more source

CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway

Open Medicine
The study aimed to investigate the effect of CD1d down-regulation on the proliferation, migration, and apoptosis of papillary thyroid carcinoma cells and explore the underlying mechanism.
Liu Qingyuan, Zhai Tong, Ma Lei, Liu Qilun   +3 more
doaj   +1 more source

Increased anergic B cells and decreased antibody‐secreting cells during romiplostim treatment in patients with immune thrombocytopenia

British Journal of Haematology, EarlyView.
Summary Patients with immune thrombocytopenia (ITP) exhibit substantial heterogeneity in treatment responses. Approximately 30%–50% of patients maintain remission after discontinuation of thrombopoietin receptor agonists (TPO‐RA), suggesting immunomodulatory effects beyond enhanced thrombopoiesis.
Vivianne S. Nelson, Rebeca Gutiérrez‐Cózar, Rebecca Cornelis, S. Marieke van Ham, Anja ten Brinke, Rick Kapur   +5 more
wiley   +1 more source

Alternative spliced CD1d transcripts in human bronchial epithelial cells.

PLoS ONE, 2011
CD1d is a MHC I like molecule which presents glycolipid to natural killer T (NKT) cells, a group of cells with diverse but critical immune regulatory functions in the immune system.
Kambez Hajipouran Benam, Wai Ling Kok, Andrew J McMichael, Ling-Pei Ho   +3 more
doaj   +1 more source