Results 61 to 70 of about 14,498 (196)

Advances in Multidimensional Molecular Mechanisms of Epilepsy and Precision Therapy Strategies

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Epilepsy arises from a multidimensional network imbalance, integrating genetic, inflammatory, and metabolic disruptions. This complexity drives neuronal hyperexcitability and underpins therapeutic challenges. Our review highlights how emerging precision strategies, from targeted molecular therapies to neuromodulation, offer a transformative path toward
Yimin Han, Jingxuan Xu, Yuntian Shen, Jitai Zhang, Xia Li, Xinlei Yao, Lei Qi, Hualin Sun   +7 more
wiley   +1 more source

The lipid transfer protein Saposin B does not directly bind CD1d for lipid antigen loading [version 2; peer review: 3 approved]

Wellcome Open Research, 2019
Background: Lipid antigens are presented on the surface of cells by the CD1 family of glycoproteins, which have structural and functional similarity to MHC class I molecules.
Maria Shamin, Tomasz H. Benedyk, Stephen C. Graham, Janet E. Deane   +3 more
doaj   +1 more source

Structural Dynamics of the Lipid Antigen-Binding Site of CD1d Protein

Biomolecules, 2020
CD1 molecules present lipid antigens to T-cells in early stages of immune responses. Whereas CD1‒lipid‒T-cell receptors interactions are reasonably understood, molecular details on initial trafficking and loading of lipids onto CD1 proteins are less ...
Bruno Cuevas-Zuviría, Marina Mínguez-Toral, Araceli Díaz-Perales, María Garrido-Arandia, Luis F. Pacios   +4 more
doaj   +1 more source

Potent NKT cell ligands overcome SARS-CoV-2 immune evasion to mitigate viral pathogenesis in mouse models.

PLoS Pathogens, 2023
One of the major pathogenesis mechanisms of SARS-CoV-2 is its potent suppression of innate immunity, including blocking the production of type I interferons.
Hongjia Lu, Zhewei Liu, Xiangxue Deng, Siyang Chen, Ruiting Zhou, Rongqi Zhao, Ramya Parandaman, Amarjot Thind, Jill Henley, Lei Tian, Jianhua Yu, Lucio Comai, Pinghui Feng, Weiming Yuan   +13 more
doaj   +1 more source

From Marginal to Central: Marginal Zone‐like B Cells as Critical Targets in Cladribine‐Treated Multiple Sclerosis

Annals of Neurology, Volume 100, Issue 4, Page 808-823, October 2026.
Objective Multiple sclerosis (MS) is a chronic autoimmune disease where B cells play a central pathogenic role. Cladribine, an oral therapy, provides durable benefits by reshaping lymphocyte populations, yet its specific long‐term impact on distinct B‐cell subsets is not fully understood.
Marta Pirronello, Mario Picozza, Gisella Guerrera, Silvia Corbisiero, Andrea Misiti, Roberta C. Placido, Alice Verdiani, Lorenzo de Marco, Manolo Sambucci, Elena Olivieri, Daniela F. Angelini, Esmeralda Quartuccio, Luca Prosperini, Carla Tortorella, Maria C. Buscarinu, Valeria Zancan, Francesca de Masi, Marco Salvetti, Claudio Gasperini, Giovanna Borsellino, Luca Battistini   +20 more
wiley   +1 more source

Human CD1D Gene Expression Is Regulated by LEF-1 through Distal Promoter Regulatory Elements [PDF]

, 2010
CD1d-expressing cells present lipid Ag to CD1d-restricted NKT cells, which play an important role in immune regulation and tumor rejection. Lymphoid enhancer-binding factor-1 (LEF-1) is one of the regulators of the Wnt signaling pathway, which is a ...
Chen, Qiao-Yi, Pincus, Seth H., Lan, Michael S., Wu, Shixiu, Ricks, David, Maclaren, Noel, Sun, Zhongsheng, Liu, Donald, Zhang, Tao   +8 more
core  

Increased CD1D polymorphism: identification of two novel alleles, CD1D*03 and *04, in individuals from Morocco.

, 2015
Two novel CD1D alleles were identified in unrelated individuals from Morocco. They differ each from the common CD1D*01 allele by one nucleotide substitution in exon 2 resulting in one amino acid change in the G-ALPHA1-LIKE domain.
Oumhani K, Del Beato T, Di Rocco M, Piancatelli D., TESSITORE, ALESSANDRA, Aureli A, El Aouad R   +6 more
core   +1 more source

Cathepsin L in cancer: Context‐dependent functions, microenvironmental regulation and translational opportunities

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Cathepsin L (CTSL) acts as a context‐dependent facilitator of tumour progression rather than a universal oncogenic driver. CTSL's pro‐tumorigenic functions are critically evaluated alongside its inherent biochemical constraints and family‐wide redundancy. CTSL‐related biology may provide translational opportunities in selected contexts.
Yujun Wu, Qin Huang, Zixuan Ding, Lin Fu, Mu Yang, Bi Peng, Pengbo Hu, Yuanhui Liu   +7 more
wiley   +1 more source

Complex structure of the Vα24− TCR with CD1d-αGalCer.

, 2013
(A) Left panel, ribbon representation of the human Vα24− TCR J24.N22 (slate, α chain; orange, β chain) in complex with human CD1d-β2m (ribbon, white) and αGalCer (sticks, yellow).
Jenny Gumperz (264372), Jacinto López-Sagaseta (301933), Jennifer E. Kung (301934), Paul B. Savage (178014), Erin J. Adams (253263)   +4 more
core   +1 more source

CD1d-expressing breast cancer cells modulate NKT cell-mediated antitumor immunity in a murine model of breast cancer metastasis. [PDF]

PLoS ONE, 2011
Tumor tolerance and immune suppression remain formidable obstacles to the efficacy of immunotherapies that harness the immune system to eradicate breast cancer.
Laura M Hix, Yihui H Shi, Randy R Brutkiewicz, Paul L Stein, Chyung-Ru Wang, Ming Zhang   +5 more
doaj   +1 more source