Results 61 to 70 of about 10,329 (179)

Cortical Thymocytes Along With Their Selecting Ligands Are Required for the Further Thymic Maturation of NKT Cells in Mice

Frontiers in Immunology, 2020
Following positive selection, NKT cell precursors enter an “NK-like” program and progress from an NK– to an NK+ maturational stage to give rise to NKT1 cells. Maturation takes place in the thymus or after emigration of NK– NKT cells to the periphery.
Jihene Klibi, Kamel Benlagha
doaj   +1 more source

Hematopoietic Antigen Presenting Cells Fine‐Tune the Effector Phenotype of Intrathymic Unconventional αβ T Cells

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Our study describes how the effector maturation of intrathymic iNKT and MAIT cells is guided by distinct hematopoietic APCs: DC1s for iNKT cells and macrophages for MAIT cells. ABSTRACT The development of unconventional αβ T cells, including invariant natural killer T (iNKT) and mucosal‐associated invariant T (MAIT) cells, in the thymus is distinct ...
Yi Wang, Trang T. Lam, Sotaro Ochiai, Abbie R. Larson, Dean B. Matthews, Hamish E.G. McWilliam, Tsuneyasu Kaisho, Mireille H. Lahoud, Jose A. Villadangos, Gretchen E. Diehl, Franca Ronchese, Daniel G. Pellicci, Mark M.W. Chong   +12 more
wiley   +1 more source

Eliminating PD‐L1 on Dendritic Cell Extracellular Vesicles for Immunotherapy Potentiates Immune‐Mediated Tumour Rejection in Mice

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
Extracellular vesicles (EVs) for immune therapy of cancer have both direct and indirect effects on immune cells. When taken up, the loaded antigen is presented by the host's dendritic cells (indirect). In this case, EV surface molecules like MHC‐peptide complexes on EVs are of minor importance. Here we show that removal of PD‐L1 from the surface of EVs
Loes Teeuwen, Loïc Steiner, Chantal Reinhardt, Annemarijn Offens, Jesse E. Kuipers, Daniel Martínez‐Martínez, Jules Mazouin, Benedict J. Chambers, Gözde Güçlüler Akpinar, Susanne Gabrielsson   +9 more
wiley   +1 more source

Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease

Journal of Neuroinflammation
The neuroinflammatory process in synucleinopathies of the aging population such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) involves microglial activation as well as infiltration of the CNS by T cells and natural killer T cells (NKTs).
Michiyo Iba, Somin Kwon, Changyoun Kim, Marcell Szabo, Liam Horan-Portelance, Maria Lopez-Ocasio, Pradeep Dagur, Cassia Overk, Robert A. Rissman, Eliezer Masliah   +9 more
doaj   +1 more source

The Dual Roles of Regulatory B Cells in Infection, Cancer, and Immunity

MedComm, Volume 7, Issue 7, July 2026.
Regulatory B cells maintain immune homeostasis via suppressive cytokines and surface molecules like PD‐L1. While beneficially suppressing autoimmunity and promoting transplant tolerance, these identical mechanisms detrimentally attenuate antipathogen and antitumor immune responses.
Anni Feng, Qilong Li, Ning Jiang, Qijun Chen   +3 more
wiley   +1 more source

Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
E. Cimini, E. Tartaglia, F. Cristofanelli, S. Gili, F. Maggi   +4 more
wiley   +1 more source

iNKT Cells and Their potential Lipid Ligands during Viral Infection

Frontiers in Immunology, 2015
Invariant natural killer T (iNKT) cells are a unique population of lipid reactive CD1d restricted innate-like T lymphocytes. Despite being a minor population, they serve as an early source of cytokines and promote immunological crosstalk thus bridging ...
Anunya eOpasawatchai, Anunya eOpasawatchai, Ponpan eMatangkasombut, Ponpan eMatangkasombut   +3 more
doaj   +1 more source

Early Epidemiologic and Immune Predictors of Atopic Dermatitis: Reduced Cord Blood Regulatory B10 Cells in the Munich Atopy Prediction Study (MAPS)

Allergy, Volume 81, Issue 7, Page 2463-2477, July 2026.
In this prospective birth cohort from Munich, comprehensive clinical assessments and longitudinal lifestyle questionnaires were combined with cord blood immune profiling. Infants who later developed AD showed altered cord blood immune signatures, including reduced CD4+ T cells, increased B cells and markedly decreased Breg cells. Epidemiologic factors,
S. Preis, S. Kaesler, M. Koeberle, M. Hils, B. Evers, R. L. Silva, Y. Skabytska, L. Schellenberger, H. Hufnagel, M. Schielein, B. Kuschel, Y. Amar, A. Zink, T. Biedermann, Z. Kurgyis   +14 more
wiley   +1 more source

CD1d-Restricted NKT Cells: An Interstrain Comparison [PDF]

The Journal of Immunology, 2001
Abstract CD1d-restricted Vα14-Jα281 invariant αβTCR+ (NKT) cells are well defined in the C57BL/6 mouse strain, but they remain poorly characterized in non-NK1.1-expressing strains. Surrogate markers for NKT cells such as αβTCR+CD4−CD8− and DX5+CD3+ have been used in many studies, although their effectiveness in defining this lineage ...
Hammond, Kirsten J. L., Pellicci, Daniel G., Poulton, Lynn D., Naidenko, Olga V., Scalzo, Anthony A., Baxter, Alan G., Godfrey, Dale I.   +6 more
openaire   +2 more sources

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

Immunology &Cell Biology, Volume 104, Issue 6, Page 595-608, July 2026.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez, Hui Jing Lim, Brunda Nijagal, Yuting Yang, Nicole Lau, Jeffrey YW Mak, David P Fairlie, Hayley Newton, Mariolina Salio, Jose A Villadangos, Hamish EG McWilliam   +10 more
wiley   +1 more source