Results 61 to 70 of about 20,572 (218)
Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells. [PDF]
PLoS Biology, 2011 Invariant natural killer T (iNKT) cells are an evolutionary conserved T cell population characterized by features of both the innate and adaptive immune response.
Enrico Girardi +9 more
doaj +1 more source
Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype. [PDF]
, 2016 In the degenerative disease Duchenne muscular dystrophy, inflammatory cells enter muscles in response to repetitive muscle damage. Immune factors are required for muscle regeneration, but chronic inflammation creates a profibrotic milieu that exacerbates
Barton, Elisabeth R +7 more
core +2 more sources
Cardiolipin Binds to CD1d and Stimulates CD1d-Restricted γδ T Cells in the Normal Murine Repertoire [PDF]
The Journal of Immunology, 2011 Abstract Cardiolipin (CL), a major phospholipid in bacterial cell walls, is sequestered from the immune system in mammalian mitochondria and is, therefore, a potential danger signal. Based on growing evidence that phospholipids constitute natural ligands for CD1 and that CD1d-restricted T cells recognize phospholipids, we hypothesized ...
Mélanie, Dieudé +8 more
openaire +2 more sources
Biochemistry and Biophysics Reports, 2020 Norovirus infection cause epidemic nonbacterial gastroenteritis in patients. The immune mechanisms responsible for the clearance of virus are not completely understood. We examined whether NKT cells are effective against norovirus infection using CD1d KO
Hiroki Ishikawa +7 more
doaj +1 more source
An Elementary Derivation of the Black-Hole Area-Entropy Relation in Any Dimension [PDF]
, 2000 A straightforward two-line derivation of the Bekenstein-Hawking Area-Entropy relation for Black-Holes in {\bf any} dimension is shown based on Shannon's information theory and Clifford algebras required by the New Relativity Principle.Comment: Tex file ...
13-Brandt +8 more
core +4 more sources
CD1d Activation and Blockade: A New Antitumor Strategy [PDF]
The Journal of Immunology, 2009 Abstract CD1d is expressed on APCs and presents glycolipids to CD1d-restricted NKT cells. For the first time, we demonstrate the ability of anti-CD1d mAbs to inhibit the growth of different CD1d-negative experimental carcinomas in mice. Anti-CD1d mAbs systemically activated CD1d+ APC, as measured by production of IFN-γ and IL-12.
Teng, Michele W. L. +4 more
openaire +3 more sources
Open MedicineThe study aimed to investigate the effect of CD1d down-regulation on the proliferation, migration, and apoptosis of papillary thyroid carcinoma cells and explore the underlying mechanism.
Liu Qingyuan +3 more
doaj +1 more source
Neurofibromin 1 Impairs Natural Killer T-Cell-Dependent Antitumor Immunity against a T-Cell Lymphoma
Frontiers in Immunology, 2018 Neurofibromin 1 (NF1) is a tumor suppressor gene encoding a Ras GTPase that negatively regulates Ras signaling pathways. Mutations in NF1 are linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome.
Jianyun Liu +6 more
doaj +1 more source
Simplexide induces CD1d-dependent cytokine and chemokine production from human monocytes. [PDF]
PLoS ONE, 2014 Monocytes are major effector cells of innate immunity and recognize several endogenous and exogenous molecules due to the expression of wide spectrum of receptors.
Stefania Loffredo +9 more
doaj +1 more source
Frontiers in Immunology, 2023 Immune Checkpoint Therapies (ICT) have revolutionized the treatment of metastatic melanoma. However, only a subset of patients reaches complete responses. Deficient β2-microglobulin (β2M) expression impacts antigen presentation to T cells, leading to ICT
Mona Meng Wang +7 more
doaj +1 more source