Results 81 to 90 of about 10,329 (179)

The Pathophysiological Relevance of the iNKT Cell/Mononuclear Phagocyte Crosstalk in Tissues

Frontiers in Immunology, 2018
CD1d-restricted Natural Killer T (NKT) cells are regarded as sentinels of tissue integrity by sensing local cell stress and damage. This occurs via recognition of CD1d-restricted lipid antigens, generated by stress-related metabolic changes, and ...
Filippo Cortesi, Gloria Delfanti, Gloria Delfanti, Giulia Casorati, Paolo Dellabona   +4 more
doaj   +1 more source

Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer

Molecules, 2014
Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T ...
Meena S. Thakur, Archana Khurana, Mitchell Kronenberg, Amy R. Howell   +3 more
doaj   +1 more source

Aberrant Presentation of Self-Lipids by Autoimmune B Cells Depletes Peripheral iNKT Cells

Cell Reports, 2014
Summary: Invariant natural killer T (iNKT) cells provide cognate help via CD1d to lipid antigen-presenting B cells for antibody production, but whether B cells reciprocally regulate iNKT cells remains largely unexplored.
Andy Hee-Meng Tan, William Pooi-Kat Chong, Sze-Wai Ng, Nurhidayah Basri, Shengli Xu, Kong-Peng Lam   +5 more
doaj   +1 more source

Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens

Nature Communications, 2016
The invariant αβTCR of type I NKT cells recognizes a lipid α-GalCer presented by CD1d. Here the authors describe atypical α-GalCer-reactive NKT cells with diverse TCRs, which bind to CD1d-α-GalCer in a manner distinct from type I NKT cells, thus ...
Jérôme Le Nours, T. Praveena, Daniel G. Pellicci, Nicholas A. Gherardin, Fiona J. Ross, Ricky T. Lim, Gurdyal S. Besra, Santosh Keshipeddy, Stewart K. Richardson, Amy R. Howell, Stephanie Gras, Dale I. Godfrey, Jamie Rossjohn, Adam P. Uldrich   +13 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Role of CD1d and iNKT cells in regulating intestinal inflammation

Frontiers in Immunology
Invariant natural killer T (iNKT) cells, a subset of unconventional T cells that recognize glycolipid antigens in a CD1d-dependent manner, are crucial in regulating diverse immune responses such as autoimmunity.
Sung Won Lee, Hyun Jung Park, Luc Van Kaer, Seokmann Hong   +3 more
doaj   +1 more source

CD1d [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Nitration of GlcCer and Related Complex Lipids Enhances CD1d Binding Affinity and Modulates Immune Responses via Lipid Antigen Presentation to Natural Killer T Cells

ChemistryEurope
Nitration of unsaturated lipids occurs through the action of the signaling molecule nitric oxide (NO) and related reactive nitrogen species. Derivatives of the most abundant glycolipid, β‐GlcCer, containing nitro‐unsaturated fatty acids are synthesized ...
Kodai Sueyoshi, Nanako Kawate‐Horiuchi, Kazunari Ueki, Risa Nozawa, Takanori Matsumaru, Yukari Fujimoto   +5 more
doaj   +1 more source

The surveillance of viral infections by the unconventional Type I NKT cell

Frontiers in Immunology
Type I NKT cells, also known as Invariant Natural Killer T (iNKT) cells, are a subpopulation of unconventional, innate-like T (ILT) cells which can proficiently influence downstream immune effector functions.
Varshini Rajashekar, Varshini Rajashekar, Lauren Stern, Lauren Stern, Catarina F. Almeida, Barry Slobedman, Barry Slobedman, Allison Abendroth, Allison Abendroth   +8 more
doaj   +1 more source

CD1D Gene [PDF]

, 2020
openaire   +1 more source