Results 81 to 90 of about 14,032 (192)

High SIGLEC10‐Expressing Tumor‐Associated Macrophages Participate in Remodeling the Tumor Immune Microenvironment and Predict Poor Prognosis in Colorectal Cancer

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Background Sialic acid‐binding immunoglobulin‐like lectin 10 (SIGLEC10), a member of the SIGLEC family, is selectively expressed on multiple immune cell subsets and plays a key role in immune regulation through the recognition of sialylated ligands.
Chuang Miao, Fei Qian
wiley   +1 more source

CD1d-Restricted NKT Cells: An Interstrain Comparison [PDF]

The Journal of Immunology, 2001
Abstract CD1d-restricted Vα14-Jα281 invariant αβTCR+ (NKT) cells are well defined in the C57BL/6 mouse strain, but they remain poorly characterized in non-NK1.1-expressing strains. Surrogate markers for NKT cells such as αβTCR+CD4−CD8− and DX5+CD3+ have been used in many studies, although their effectiveness in defining this lineage ...
Hammond, Kirsten J. L., Pellicci, Daniel G., Poulton, Lynn D., Naidenko, Olga V., Scalzo, Anthony A., Baxter, Alan G., Godfrey, Dale I.   +6 more
openaire   +2 more sources

Could Fabry Disease Cause Giant Coronary Aneurysms in a 7‐Month‐Old Infant: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Fabry disease is a rare X‐linked lysosomal storage disorder that can affect multiple organs. Cardiac involvement, one of its significant manifestations, can begin in childhood and is more prevalent in males, with severity increasing with age and disease progression.
Reza Shabanian, Minoo Dadkhah, Rana Doroudian, Mehrnaz Adib, Sahar Naderi, Khashayar Ashkboos   +5 more
wiley   +1 more source

HSV-1 UL56 protein recruits cellular NEDD4-family ubiquitin ligases to suppress CD1d expression and NKT cell function

Journal of Virology
Herpesviruses, including α-herpesvirus and herpes simplex virus (HSV-1), are masters of immune evasion. Previously we demonstrated that CD1d-restricted NKT cells are required for optimal anti-HSV-1 immune responses and HSV-1 efficiently downregulates ...
Lingxi Qiu, Xuedi Gao, Xinyue Shao, Jingwen Xi, Siyang Chen, Thanh Pham, Yi Wang, Jonathan Dong, Samhita Divakar Rao, Jingting Hao, Jae Ho Lo, Rirong Yang, Esteban A. Engel, Colin M. Crump, Weiming Yuan   +14 more
doaj   +1 more source

iNKT Cells and Their potential Lipid Ligands during Viral Infection

Frontiers in Immunology, 2015
Invariant natural killer T (iNKT) cells are a unique population of lipid reactive CD1d restricted innate-like T lymphocytes. Despite being a minor population, they serve as an early source of cytokines and promote immunological crosstalk thus bridging ...
Anunya eOpasawatchai, Anunya eOpasawatchai, Ponpan eMatangkasombut, Ponpan eMatangkasombut   +3 more
doaj   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, Volume 2, Issue 3, July 2026.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Regulatory Role of CD1d in Neurotropic Virus Infection [PDF]

Journal of Virology, 2008
ABSTRACTThe GDVII strain of Theiler's murine encephalomyelitis virus (TMEV) causes an acute fatal polioencephalomyelitis in mice. Infection of susceptible mice with the DA strain of TMEV results in an acute polioencephalomyelitis followed by chronic immune-mediated demyelination with virus persistence in the central nervous system (CNS); DA virus ...
Ikuo, Tsunoda, Tomoko, Tanaka, Robert S, Fujinami   +2 more
openaire   +2 more sources

Eliminating PD‐L1 on Dendritic Cell Extracellular Vesicles for Immunotherapy Potentiates Immune‐Mediated Tumour Rejection in Mice

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
Extracellular vesicles (EVs) for immune therapy of cancer have both direct and indirect effects on immune cells. When taken up, the loaded antigen is presented by the host's dendritic cells (indirect). In this case, EV surface molecules like MHC‐peptide complexes on EVs are of minor importance. Here we show that removal of PD‐L1 from the surface of EVs
Loes Teeuwen, Loïc Steiner, Chantal Reinhardt, Annemarijn Offens, Jesse E. Kuipers, Daniel Martínez‐Martínez, Jules Mazouin, Benedict J. Chambers, Gözde Güçlüler Akpinar, Susanne Gabrielsson   +9 more
wiley   +1 more source

CD1d-dependent CLL progression? [PDF]

Blood, 2017
In this issue of Blood , Gorini et al provide compelling evidence for an indirect CD1d- and natural killer T (NKT) cell–dependent mechanism that promotes disease progression in chronic lymphocytic leukemia (CLL ...
openaire   +2 more sources

Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
E. Cimini, E. Tartaglia, F. Cristofanelli, S. Gili, F. Maggi   +4 more
wiley   +1 more source