Results 81 to 90 of about 14,498 (196)

TGFβ Inhibits CD1d Expression on Dendritic Cells [PDF]

Journal of Investigative Dermatology, 2005
The CD1 family of cell surface glycoprotein has been demonstrated to be a third lineage of antigen-presenting molecules for specific T cell responses. They present lipidic, glycolipidic antigen and hydrophobic peptide to T cells. CD1d restricted T cells play a role in autoimmune disease and in tumor immunity.
Ronger-Savle, S., Valladeau, J., Claudy, A., Schmitt, D., Peguet-Navarro, J., Dezutter-Dambuyant, C., Thomas, L., Jullien, D.   +7 more
openaire   +2 more sources

Building an Interleukin‐10‐Producing Identity: How B Cells Acquire Interleukin‐10 Competence and How Plasma Cell Differentiation Consolidates This Program

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT Interleukin (IL)‐10‐producing B cells represent an archetype for the regulatory functions of B cells. Here, we review the cell‐surface receptors and transcriptional regulators that control IL‐10 expression in B cells and enable their regulatory function in vivo.
Bui Thi Cuc, Yanli Tong, Zhiguo Wu, Daniel Alvarez‐Simon, Simon Fillatreau   +4 more
wiley   +1 more source

HSV-1 UL56 protein recruits cellular NEDD4-family ubiquitin ligases to suppress CD1d expression and NKT cell function

Journal of Virology
Herpesviruses, including α-herpesvirus and herpes simplex virus (HSV-1), are masters of immune evasion. Previously we demonstrated that CD1d-restricted NKT cells are required for optimal anti-HSV-1 immune responses and HSV-1 efficiently downregulates ...
Lingxi Qiu, Xuedi Gao, Xinyue Shao, Jingwen Xi, Siyang Chen, Thanh Pham, Yi Wang, Jonathan Dong, Samhita Divakar Rao, Jingting Hao, Jae Ho Lo, Rirong Yang, Esteban A. Engel, Colin M. Crump, Weiming Yuan   +14 more
doaj   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, Volume 13, Issue 54, 28 September 2026.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

The CDR3β loop strongly impacts on human iNKT TCR affinity to CD1d, independent of the CD1d-bound ligand.

, 2013
(A) Binding of two recombinant human iNKT TCRs, one OCHHIGH (4C1369) and one OCHLOW (4C12), to K7-, OCH-, βGC-, and LacCer-CD1d at equilibrium is shown (see also panel C and Table 2).
Daniel Schümperli (27023), Gopal R. Bommineni (363741), Gediminas Matulis (363733), Nikolai M. Lissin (363736), Peter M. Villiger (206223), Joseph P. Sanderson (363734), Maria B. Asparuhova (363738), Stephan D. Gadola (363749), Bent K. Jakobsen (363747), Richard R. Schmidt (363744)   +9 more
core   +1 more source

Natural Killer Cell Dysfunction Is Emerging During Midlife Obesity

Aging Cell, Volume 25, Issue 9, September 2026.
Midlife obesity was associated with impaired NK cell function, including decreased degranulation and IFN‐γ production. The loss of NK cell function might explain the greater mortality risk in middle‐aged individuals, highlighting the importance of monitoring immune alterations during midlife.
Ruojia Biao, Xudong Wang, Jiantao Fu, Yifan Guo, Junming He, Juan Du   +5 more
wiley   +1 more source

BAFF and APRIL Receptors in B Cell Immunity and Autoimmunity

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT BAFF and APRIL are TNF superfamily proteins that bind to BAFFR, TACI and BCMA, members of the TNF receptor superfamily. These proteins have both unique and overlapping roles in B cell development and survival and are major therapeutic targets for antibody‐ and B‐cell‐driven pathologies.
Daisy H. Luff, Edina Schweighoffer, Victor L. J. Tybulewicz   +2 more
wiley   +1 more source

Table_1_Sortase A-Cleavable CD1d Identifies Sphingomyelins as Major Class of CD1d-Associated Lipids.xlsx

, 2022
CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids and can activate natural killer T (NKT) cells through the presentation of lipid antigens.
Maren Rudolph (11726318), Gijsbert Grotenbreg (2501017), Sebastian Zeissig (11722340), Theresa Simolka (13013718), Gurdyal Singh Besra (13013721), Anna Shevchenko (257435), Andrej Shevchenko (148659), Lingyun Dai (6057665), Emilie Huc-Claustre (3749257), Yuting Wang (434390)   +9 more
core   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source

DataSheet_1_Sortase A-Cleavable CD1d Identifies Sphingomyelins as Major Class of CD1d-Associated Lipids.docx

, 2022
CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids and can activate natural killer T (NKT) cells through the presentation of lipid antigens.
Maren Rudolph (11726318), Gijsbert Grotenbreg (2501017), Sebastian Zeissig (11722340), Theresa Simolka (13013718), Gurdyal Singh Besra (13013721), Anna Shevchenko (257435), Andrej Shevchenko (148659), Lingyun Dai (6057665), Emilie Huc-Claustre (3749257), Yuting Wang (434390)   +9 more
core   +1 more source