Results 91 to 100 of about 14,032 (192)
Contribution of NKT cells to the immune response and pathogenesis triggered by respiratory viruses
Virulence, 2020 Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) cause acute respiratory tract infections in children worldwide. Natural killer T (NKT) cells are unconventional T lymphocytes, and their TCRs recognize glycolipids bound to the MHC-
Emma Rey-Jurado +6 more
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, 2003 CD1d-restricted NKT cells are a novel T cell lineage with unusual features. They co-express some NK cell receptors and recognize glycolipid antigens through an invariant T cell receptor (TCR) in the context of CD1d molecules.
M A Siomos (13750042) +5 more
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Cancer Medicine, 2019 Background Anaplastic thyroid carcinomas are associated with rapid tumor growth, short survival time and without any promising therapy to improve the poor prognosis.
Florian Weber +6 more
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The Pathophysiological Relevance of the iNKT Cell/Mononuclear Phagocyte Crosstalk in Tissues
Frontiers in Immunology, 2018 CD1d-restricted Natural Killer T (NKT) cells are regarded as sentinels of tissue integrity by sensing local cell stress and damage. This occurs via recognition of CD1d-restricted lipid antigens, generated by stress-related metabolic changes, and ...
Filippo Cortesi +4 more
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Investigation of HDAC Inhibitors-induced CD1d Expression
, 2010 本論文探討新穎抗癌藥物，HDAC抑制劑引發CD1d表現與其免疫調節之功能。在A549和TC-1細胞，TSA和SAHA引發dose-及time-dependent之CD1d表現，進一步探討TSA誘導CD1d mRNA表現之機轉，A549及TC-1細胞預先處理PKC抑制劑Ro318220、ROCK抑制劑Y27632、CaM kinase II抑制劑KN-62、p38抑制劑SB203580、MEK抑制劑PD98059、JNK抑制劑SP600125、PI3K抑制劑LY294002 ...
林沛潔, Lin, Pei-Jie
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Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer
Molecules, 2014 Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T ...
Meena S. Thakur +3 more
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, 2013 Hepatic CD1d-restricted and natural killer T-cell populations are heterogeneous. Classical 'type 1′ α-galactosylceramide-reactive CD1d-restricted T cells express 'invariant' TCRα ('iNKT').
Rosen, H.R. +23 more
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Aberrant Presentation of Self-Lipids by Autoimmune B Cells Depletes Peripheral iNKT Cells
Cell Reports, 2014 Summary: Invariant natural killer T (iNKT) cells provide cognate help via CD1d to lipid antigen-presenting B cells for antibody production, but whether B cells reciprocally regulate iNKT cells remains largely unexplored.
Andy Hee-Meng Tan +5 more
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The role of CD1d in adipogenesis
, 2007 Atherosclerosis-associated coronary heart disease is the number one cause of death in the western society, and often triggered by metabolic disorders, such as hyperlipidemia, hypertension, obesity, and diabetes.
Rosales, Corina
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Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens
Nature Communications, 2016 The invariant αβTCR of type I NKT cells recognizes a lipid α-GalCer presented by CD1d. Here the authors describe atypical α-GalCer-reactive NKT cells with diverse TCRs, which bind to CD1d-α-GalCer in a manner distinct from type I NKT cells, thus ...
Jérôme Le Nours +13 more
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