Results 91 to 100 of about 13,147 (200)
Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity
Advanced Science, Volume 13, Issue 13, 3 March 2026.TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao +14 more
wiley +1 more source
Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis
, 2009 Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis Background: The role of cytotoxicity of NKT-cells in the skin is not defined. There are two prototypic skin diseases in which epidermal Keratinocytes (KC) over-express CD1d, a
Balato, Anna
core
, 2013 Hepatic CD1d-restricted and natural killer T-cell populations are heterogeneous. Classical 'type 1′ α-galactosylceramide-reactive CD1d-restricted T cells express 'invariant' TCRα ('iNKT').
Rosen, H.R. +23 more
core +1 more source
Helminths as architects of trained tolerance: implications for human health
Clinical &Translational Immunology, Volume 15, Issue 3, 2026.Abstract Helminths infect nearly 2 billion people worldwide and are a major cause of chronic morbidity in low‐resource regions. Unlike bacterial and viral pathogens that elicit protective memory, helminths actively remodel host immunity to enable their years‐long persistence and reinfection.
Quinn Moroz +2 more
wiley +1 more source
European Journal of Immunology, Volume 56, Issue 3, March 2026.This is an update to the Guidelines for the Use of Flow Cytometry and Cell Sorting in Immunological Studies (Third Edition), Chapter 12C, by Cossarizza et al. A 38‐marker full‐spectrum flow cytometry panel enabling high‐resolution profiling of human γδ T cells across blood and lymphoid tissues, including robust identification of rare, tissue‐adapted ...
Mohamed Hamed +8 more
wiley +1 more source
, 2003 CD1d-restricted NKT cells are a novel T cell lineage with unusual features. They co-express some NK cell receptors and recognize glycolipid antigens through an invariant T cell receptor (TCR) in the context of CD1d molecules.
M A Siomos (13750042) +5 more
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SARS-CoV-2 infection downregulates CD1d in antigen-presenting cells.
, 2023 (A-C). Human peripheral blood monocytes were purified from a healthy donor, derived into dendritic cells, stained with surface markers (A) and infected with SARS-CoV-2 (Isolate USA-WA1/2020) at m.o.i. of 10.
Weiming Yuan (634451) +13 more
core +1 more source
Contribution of NKT cells to the immune response and pathogenesis triggered by respiratory viruses
Virulence, 2020 Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) cause acute respiratory tract infections in children worldwide. Natural killer T (NKT) cells are unconventional T lymphocytes, and their TCRs recognize glycolipids bound to the MHC-
Emma Rey-Jurado +6 more
doaj +1 more source
Investigation of HDAC Inhibitors-induced CD1d Expression
, 2010 本論文探討新穎抗癌藥物，HDAC抑制劑引發CD1d表現與其免疫調節之功能。在A549和TC-1細胞，TSA和SAHA引發dose-及time-dependent之CD1d表現，進一步探討TSA誘導CD1d mRNA表現之機轉，A549及TC-1細胞預先處理PKC抑制劑Ro318220、ROCK抑制劑Y27632、CaM kinase II抑制劑KN-62、p38抑制劑SB203580、MEK抑制劑PD98059、JNK抑制劑SP600125、PI3K抑制劑LY294002 ...
林沛潔, Lin, Pei-Jie
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Characterisation of expression and function of respiratory epithelial CD1d
, 2014 In this thesis, I examined the expression of CD1d on respiratory epithelial cells (REC) in human and explored its potential role in mucosal immunity in the lungs. Hitherto, there have been no published reports of CD1d expression on REC though it has been
Ho, Ling-Pei, Hajipouran Benam, Kambez
core +2 more sources