Results 91 to 100 of about 14,498 (196)

CD1d-dependent CLL progression? [PDF]

Blood, 2017
In this issue of Blood , Gorini et al provide compelling evidence for an indirect CD1d- and natural killer T (NKT) cell–dependent mechanism that promotes disease progression in chronic lymphocytic leukemia (CLL ...
openaire   +2 more sources

Contribution of NKT cells to the immune response and pathogenesis triggered by respiratory viruses

Virulence, 2020
Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) cause acute respiratory tract infections in children worldwide. Natural killer T (NKT) cells are unconventional T lymphocytes, and their TCRs recognize glycolipids bound to the MHC-
Emma Rey-Jurado, Karen Bohmwald, Nicolás M.S. Gálvez, Daniela Becerra, Steven A. Porcelli, Leandro J. Carreño, Alexis M. Kalergis   +6 more
doaj   +1 more source

Increased cytoplasmatic expression of cancer immune surveillance receptor CD1d in anaplastic thyroid carcinomas

Cancer Medicine, 2019
Background Anaplastic thyroid carcinomas are associated with rapid tumor growth, short survival time and without any promising therapy to improve the poor prognosis.
Florian Weber, Henrik Junger, Jens M. Werner, Natalia Velez Char, Carolina Rejas, Hans J. Schlitt, Matthias Hornung   +6 more
doaj   +1 more source

The Pathophysiological Relevance of the iNKT Cell/Mononuclear Phagocyte Crosstalk in Tissues

Frontiers in Immunology, 2018
CD1d-restricted Natural Killer T (NKT) cells are regarded as sentinels of tissue integrity by sensing local cell stress and damage. This occurs via recognition of CD1d-restricted lipid antigens, generated by stress-related metabolic changes, and ...
Filippo Cortesi, Gloria Delfanti, Gloria Delfanti, Giulia Casorati, Paolo Dellabona   +4 more
doaj   +1 more source

Investigation of HDAC Inhibitors-induced CD1d Expression

, 2010
本論文探討新穎抗癌藥物，HDAC抑制劑引發CD1d表現與其免疫調節之功能。在A549和TC-1細胞，TSA和SAHA引發dose-及time-dependent之CD1d表現，進一步探討TSA誘導CD1d mRNA表現之機轉，A549及TC-1細胞預先處理PKC抑制劑Ro318220、ROCK抑制劑Y27632、CaM kinase II抑制劑KN-62、p38抑制劑SB203580、MEK抑制劑PD98059、JNK抑制劑SP600125、PI3K抑制劑LY294002 ...
林沛潔, Lin, Pei-Jie
core  

Table_2_Sortase A-Cleavable CD1d Identifies Sphingomyelins as Major Class of CD1d-Associated Lipids.xlsx

, 2022
CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids and can activate natural killer T (NKT) cells through the presentation of lipid antigens.
Maren Rudolph (11726318), Gijsbert Grotenbreg (2501017), Sebastian Zeissig (11722340), Theresa Simolka (13013718), Gurdyal Singh Besra (13013721), Anna Shevchenko (257435), Andrej Shevchenko (148659), Lingyun Dai (6057665), Emilie Huc-Claustre (3749257), Yuting Wang (434390)   +9 more
core   +1 more source

Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer

Molecules, 2014
Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T ...
Meena S. Thakur, Archana Khurana, Mitchell Kronenberg, Amy R. Howell   +3 more
doaj   +1 more source

CD1d-restricted NKT cells contribute to malarial splenomegaly and enhance parasite-specific antibody responses

, 2003
CD1d-restricted NKT cells are a novel T cell lineage with unusual features. They co-express some NK cell receptors and recognize glycolipid antigens through an invariant T cell receptor (TCR) in the context of CD1d molecules.
M A Siomos (13750042), Tania De Koning-Ward (13096974), L Schofield (11009721), B Crabb (13290801), D Hansen (7937381), L Buckingham (13750045)   +5 more
core  

Ex vivo analysis of resident hepatic pro-inflammatory CD1d-reactive T cells and hepatocyte surface CD1d expression in hepatitis C

, 2013
Hepatic CD1d-restricted and natural killer T-cell populations are heterogeneous. Classical 'type 1′ α-galactosylceramide-reactive CD1d-restricted T cells express 'invariant' TCRα ('iNKT').
Van Der Vliet, H. J., Wang, R., Schuppan, D., L. Golden-Mason, D. Schuppan, Golden-Mason, L., Rosen, H. R., K. Yanagisawa, H. J. van der Vliet, Yue, S., M. A. Exley, R. Wang, N. Alatrakchi, Koziel, M. J., H. R. Rosen, Exley, M. A., Yanagisawa, K., M. J. Koziel, Alatrakchi, N., S. Yue   +19 more
core   +1 more source

Aberrant Presentation of Self-Lipids by Autoimmune B Cells Depletes Peripheral iNKT Cells

Cell Reports, 2014
Summary: Invariant natural killer T (iNKT) cells provide cognate help via CD1d to lipid antigen-presenting B cells for antibody production, but whether B cells reciprocally regulate iNKT cells remains largely unexplored.
Andy Hee-Meng Tan, William Pooi-Kat Chong, Sze-Wai Ng, Nurhidayah Basri, Shengli Xu, Kong-Peng Lam   +5 more
doaj   +1 more source