Results 101 to 110 of about 14,498 (196)

Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens

Nature Communications, 2016
The invariant αβTCR of type I NKT cells recognizes a lipid α-GalCer presented by CD1d. Here the authors describe atypical α-GalCer-reactive NKT cells with diverse TCRs, which bind to CD1d-α-GalCer in a manner distinct from type I NKT cells, thus ...
Jérôme Le Nours, T. Praveena, Daniel G. Pellicci, Nicholas A. Gherardin, Fiona J. Ross, Ricky T. Lim, Gurdyal S. Besra, Santosh Keshipeddy, Stewart K. Richardson, Amy R. Howell, Stephanie Gras, Dale I. Godfrey, Jamie Rossjohn, Adam P. Uldrich   +13 more
doaj   +1 more source

CD1d-specific single-domain antibodies for unconventional immunomodulation [PDF]

Bispecific T cell engagers (bsTCEs) in clinical development and/or (recently) approved as standard of care, face challenges related to the bsTCE format (e.g half-life, tumor penetration, immunogenicity, stability) and targeted effector cells population ...
Lameris, Roeland
core   +1 more source

Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor

, 2012
Natural killer T cells (NKT cells) are divided into type I and type II subsets on the basis of differences in their T cell antigen receptor (TCR) repertoire and CD1d-antigen specificity.
Laurent Gapin, Clarke, Andrew J, Patel, Onisha, Cardell, Susanna,, Maria L Sandoval-Romero, Godfrey, Dale I., Susanna L Cardell, Pellicci, Daniel G, Jérôme Le Nours, Clarke, Andrew J., Le Nours, Jérôme, Gras, Stephanie, Cardell, Susanna L., Andrew J Clarke, Sandoval-Romero, Maria L., Uldrich, Adam P., Theodossis, Alex, Gapin, Laurent, Daniel G Pellicci, Stephanie Gras, Jamie Rossjohn, Mallevaey, Thierry, Thierry Mallevaey, Alex Theodossis, Adam P Uldrich, Sandoval-Romero, Maria L, Dale I Godfrey, Onisha Patel, Rossjohn, Jamie, Uldrich, Adam P, Pellicci, Daniel G., Godfrey, Dale I   +31 more
core   +1 more source

Role of CD1d and iNKT cells in regulating intestinal inflammation

Frontiers in Immunology
Invariant natural killer T (iNKT) cells, a subset of unconventional T cells that recognize glycolipid antigens in a CD1d-dependent manner, are crucial in regulating diverse immune responses such as autoimmunity.
Sung Won Lee, Hyun Jung Park, Luc Van Kaer, Seokmann Hong   +3 more
doaj   +1 more source

BCR targeting of biotin-alpha-galactosylceramide leads to enhanced presentation on CD1d and requires transport of BCR to CD1d-containing endocytic compartments

, 2005
CD1d is a non-polymorphic MHC class I-related protein that binds and presents glycolipid antigens to T cell antigen receptors expressed by NK-like T (NKT) cells.
Gillian A. Lang, Petr A. Illarionov, Mark L. Lang, Illarionov, Petr, Gurdyal S. Besra, Lang, GA, Besra, Gurdyal; id_orcid, Glatman-Freedman, A, Lang, ML, Aharona Glatman-Freedman   +9 more
core   +1 more source

CD1d [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Nitration of GlcCer and Related Complex Lipids Enhances CD1d Binding Affinity and Modulates Immune Responses via Lipid Antigen Presentation to Natural Killer T Cells

ChemistryEurope
Nitration of unsaturated lipids occurs through the action of the signaling molecule nitric oxide (NO) and related reactive nitrogen species. Derivatives of the most abundant glycolipid, β‐GlcCer, containing nitro‐unsaturated fatty acids are synthesized ...
Kodai Sueyoshi, Nanako Kawate‐Horiuchi, Kazunari Ueki, Risa Nozawa, Takanori Matsumaru, Yukari Fujimoto   +5 more
doaj   +1 more source

CD1d structure and regulation on human thymocytes, peripheral blood T cells, B cells and monocytes

, 2000
Human T cells expressing CD161 and an invariant T-cell receptor (TCR) α-chain (Vα24(invt) T cells) specifically recognize CD1d and appear to have immunoregulatory functions.
Porcelli, S., Exley, M., Tahir, S. M A, Blumberg, R. S., Garcia, J., Balk, Steven P., Gerdes, D., Patton, K. T., Wilson, S. B., Chott, A., Spada, F.   +10 more
core   +1 more source

The surveillance of viral infections by the unconventional Type I NKT cell

Frontiers in Immunology
Type I NKT cells, also known as Invariant Natural Killer T (iNKT) cells, are a subpopulation of unconventional, innate-like T (ILT) cells which can proficiently influence downstream immune effector functions.
Varshini Rajashekar, Varshini Rajashekar, Lauren Stern, Lauren Stern, Catarina F. Almeida, Barry Slobedman, Barry Slobedman, Allison Abendroth, Allison Abendroth   +8 more
doaj   +1 more source

CD1D Gene [PDF]

, 2020
openaire   +1 more source