Results 101 to 110 of about 20,572 (218)

Alterations in cellular metabolism modulate CD1d-mediated NKT-cell responses [PDF]

, 2016
Natural killer T (NKT) cells play a critical role in the host's innate immune response. CD1d-mediated presentation of glycolipid antigens to NKT cells has been established; however, the mechanisms by which NKT cells recognize infected or cancerous cells ...
Bollino, Dominique R., Brutkiewicz, Randy R., Carey, Gregory B., East, James E., Kimball, Amy S., Sun, Wenji, Webb, Tonya J.   +6 more
core   +1 more source

Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity

Advanced Science, Volume 13, Issue 13, 3 March 2026.
TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao, Chengming Qu, Yanzhao Zhou, Xiaoqian Wang, Xiangjun Qian, Xun Chen, Feng Han, Xiaokai Zhang, Yiyi Ji, Han Li, ChengWei Ju, Peng Xia, Weiwei Tang, Hao Zhuang, Jinxue Zhou   +14 more
wiley   +1 more source

Regulatory Role of CD1d in Neurotropic Virus Infection [PDF]

Journal of Virology, 2008
ABSTRACTThe GDVII strain of Theiler's murine encephalomyelitis virus (TMEV) causes an acute fatal polioencephalomyelitis in mice. Infection of susceptible mice with the DA strain of TMEV results in an acute polioencephalomyelitis followed by chronic immune-mediated demyelination with virus persistence in the central nervous system (CNS); DA virus ...
Ikuo, Tsunoda, Tomoko, Tanaka, Robert S, Fujinami   +2 more
openaire   +2 more sources

CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells [PDF]

, 2018
Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function of CD1d in Breg biology and iNKT cell activity during inflammation remains unclear.
Bosma, A, Drozdov, I, Matei, DE, Mauri, C, Nistala, K, Oleinika, K, Rosser, EC   +6 more
core   +2 more sources

Helminths as architects of trained tolerance: implications for human health

Clinical &Translational Immunology, Volume 15, Issue 3, 2026.
Abstract Helminths infect nearly 2 billion people worldwide and are a major cause of chronic morbidity in low‐resource regions. Unlike bacterial and viral pathogens that elicit protective memory, helminths actively remodel host immunity to enable their years‐long persistence and reinfection.
Quinn Moroz, Jorge Lucas Nascimento Souza, Neima Briggs   +2 more
wiley   +1 more source

NKT TCR Recognition of CD1d-α-C-Galactosylceramide [PDF]

The Journal of Immunology, 2011
Abstract NKT cells respond to a variety of CD1d-restricted glycolipid Ags that are structurally related to the prototypic Ag α-galactosylceramide (α-GalCer). A modified analog of α-GalCer with a carbon-based glycosidic linkage (α-C-GalCer) has generated great interest because of its apparent ability to promote prolonged, Th1-biased ...
Patel, Onisha, Cameron, Garth, Pellicci, Daniel G., Liu, Zheng, Byun, Hoe-Sup, Beddoe, Travis, McCluskey, James, Franck, Richard W., Castaño, A. Raúl, Harrak Serifi, Youssef, Llebaria, Amadeu, Bittman, Robert, Porcelli, Steven A., Godfrey, Dale I., Rossjohn, Jamie   +14 more
openaire   +3 more sources

Invariant NKT Cell Response to Dengue Virus Infection in Human [PDF]

, 2014
BACKGROUND:Dengue viral infection is a global health threat without vaccine or specific treatment. The clinical outcome varies from asymptomatic, mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF).
Chan-in, W, Duangchinda, T, Limpitikul, W, Malasit, P, Matangkasombut, P, Mongkolsapaya, J, Opasawaschai, A, Pongchaikul, P, Screaton, G, Tangthawornchaikul, N, Vasanawathana, S   +10 more
core   +4 more sources

38‐Marker Full‐Spectrum Flow Cytometry Panel for the Comprehensive Profiling of γδ T Cells in Human Blood and Lymphoid Tissues

European Journal of Immunology, Volume 56, Issue 3, March 2026.
This is an update to the Guidelines for the Use of Flow Cytometry and Cell Sorting in Immunological Studies (Third Edition), Chapter 12C, by Cossarizza et al. A 38‐marker full‐spectrum flow cytometry panel enabling high‐resolution profiling of human γδ T cells across blood and lymphoid tissues, including robust identification of rare, tissue‐adapted ...
Mohamed Hamed, Daniela Moreno‐Vicencio, Daniel Arsovski, Mustafa Farhat, Rosie Sanders, Ellen Mann, Annabelle Bennett, Priyanka Chevour, Martin S. Davey   +8 more
wiley   +1 more source

Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice. [PDF]

, 2016
Invariant Natural Killer T (iNKT) cells are a unique subset of T lymphocytes that have been implicated in both promoting and suppressing a multitude of immune responses. In mice, iNKT cells express T cell antigen receptors (TCRs) comprising a unique TCRα
Bedel, R., Gapin, L., Gross, J., Krovi, S.H., Matsuda, J.L., Tuttle, K.D., Zhang, B., Zhang, J.   +7 more
core   +1 more source

Tumor‐infiltrating B cells participate in shaping the immunosuppressive microenvironment in solid tumors

International Journal of Cancer, Volume 158, Issue 5, Page 1156-1165, 1 March 2026.
Abstract Tumor‐infiltrating B cells (TIBs) exhibit dual roles in the tumor microenvironment (TME) of solid tumors. While they can enhance anti‐tumor immunity through antibody production and immune activation, certain subsets—such as regulatory B cells (Bregs) and immunosuppressive plasma cells—contribute to immune evasion by secreting inhibitory ...
Zhitong Li, Ziyang Shen, Yuxiang Sun, Pengcheng Zhu, Tongyan Liu, Rong Yin   +5 more
wiley   +1 more source