Results 1 to 10 of about 56,922 (152)
ER stress in antigen-presenting cells promotes NKT cell activation through endogenous neutral lipids. [PDF]
EMBO Rep, 2020 CD1d-restricted invariant natural killer T (iNKT) cells constitute a common glycolipid-reactive innate-like T-cell subset with a broad impact on innate and adaptive immunity.
Govindarajan S +13 more
europepmc +3 more sources
Immune evasion of the CD1d/NKT cell axis. [PDF]
Curr Opin Immunol, 2018 Many reviews on the CD1d/NKT cell axis focus on the ability of CD1d-restricted NKT cells to serve as effector cells in a variety of disorders, be they infectious diseases, cancer or autoimmunity.
Brutkiewicz RR, Yunes-Medina L, Liu J.
europepmc +3 more sources
NKT Cell Responses to B Cell Lymphoma [PDF]
Medical Sciences (Basel, Switzerland), 2014 Natural killer T (NKT) cells are a unique subset of CD1d-restricted T lymphocytes that express characteristics of both T cells and natural killer cells. NKT cells mediate tumor immune-surveillance; however, NKT cells are numerically reduced and functionally impaired in lymphoma patients.
Wenji Sun +2 more
exaly +4 more sources
Regulatory T cells induce CD4- NKT cell anergy and suppress NKT cell cytotoxic function. [PDF]
Cancer Immunol Immunother, 2019 Due to the strong tumoricidal activities of activated natural killer T (NKT) cells, invariant NKT cell-based immunotherapy has shown promising clinical efficacy. However, suppressive factors, such as regulatory T cells (Tregs), may be obstacles in the use of NKT cell-based cancer immunotherapy for advanced cancer patients.
Ihara F +9 more
europepmc +3 more sources
Distinct blood and visceral adipose tissue regulatory T cell and innate lymphocyte profiles characterize obesity and colorectal cancer [PDF]
, 2017 Visceral adipose tissue (VAT) is a main site where metabolic and immunologic processes interplay to regulate, at local and systemic level, the inflammatory status and immune response.
Barbara Varano +14 more
core +14 more sources
The Current Landscape of NKT Cell Immunotherapy and the Hills Ahead. [PDF]
Cancers (Basel), 2021 Nelson A, Lukacs JD, Johnston B.
europepmc +2 more sources
Harnessing NKT cells for vaccination [PDF]
Oxford Open Immunology, 2021 Lay Summary Vaccine-induced immune responses generally involve activation of immune cells called T and B cells that have a variety of mechanisms to limit the infection. Each T or B cell has a randomly generated receptor for binding pathogen-derived antigens, but only a few cells with an individual’s repertoire of cells will recognize a ...
Olivia K Burn +4 more
openaire +2 more sources
Regulation of NKT Cells by Ly49: Analysis of Primary NKT Cells and Generation of NKT Cell Line [PDF]
The Journal of Immunology, 2001 Abstract TCRαβ+NK1.1+ (NKT) cells are known to express various NK cell-associated molecules including the Ly49 family of receptors for MHC class I, but its functional significance has been unclear. Here, we examined the expression of Ly49A, C/I and G2 on various NKT cell populations from normal and MHC class I-deficient C57BL/6 mice as ...
M, Maeda +3 more
openaire +2 more sources
NKT cells in mucosal immunity [PDF]
Mucosal Immunology, 2009 The gastrointestinal tract allows the residence of an almost enumerable number of bacteria. To maintain homeostasis, the mucosal immune system must remain tolerant to the commensal microbiota and eradicate pathogenic bacteria. Aberrant interactions between the mucosal immune cells and the microbiota have been implicated in the pathogenesis of ...
Middendorp, Sabine, Nieuwenhuis, EES
openaire +2 more sources
NKT Cells in Neurological Diseases [PDF]
Frontiers in Cellular Neuroscience, 2019 Natural killer T (NKT) cells are a unique subset of T lymphocytes with the expression of T cell receptor (TCR) and NK cell lineage receptors. These cells can rapidly release large quantities of cytokines and function as a bridge between innate and adaptive immunity.
Yu Cui, Qi Wan
openaire +3 more sources