Results 31 to 40 of about 5,262,931 (244)

NKT cells in mucosal immunity [PDF]

Mucosal Immunology, 2009
The gastrointestinal tract allows the residence of an almost enumerable number of bacteria. To maintain homeostasis, the mucosal immune system must remain tolerant to the commensal microbiota and eradicate pathogenic bacteria. Aberrant interactions between the mucosal immune cells and the microbiota have been implicated in the pathogenesis of ...
Middendorp, Sabine, Nieuwenhuis, EES
openaire   +2 more sources

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

The role of NKT cells in gastrointestinal cancers [PDF]

OncoImmunology, 2021
Gastrointestinal (GI) cancers represent a complex array of cancers that affect the digestive system. This includes liver, pancreatic, colon, rectal, anal, gastric, esophageal, intestinal and gallbladder cancer. Patients diagnosed with certain GI cancers typically have low survival rates, so new therapeutic approaches are needed. A potential approach is
Julian Burks, Purevdorj B. Olkhanud, Jay A. Berzofsky   +2 more
openaire   +3 more sources

Possible Therapeutic Application of Targeting Type II Natural Killer T Cell-Mediated Suppression of Tumor Immunity

Frontiers in Immunology, 2018
Natural killer T (NKT) cells are a unique T cell subset that exhibits characteristics from both the innate immune cells and T cells. There are at least two subsets of NKT cells, type I and type II.
Shingo Kato, Jay A. Berzofsky, Masaki Terabe   +2 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis [PDF]

, 2009
Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis Background: The role of cytotoxicity of NKT-cells in the skin is not defined. There are two prototypic skin diseases in which epidermal Keratinocytes (KC) over-express CD1d, a
Balato, Anna
core   +1 more source

Betting on NKT and NK Cells [PDF]

Immunity, 2004
Natural killer T (NKT) cells, as their name implies, constitutively express markers and receptors first identified on bona fide natural killer (NK) cells, supporting a potential relationship between NKT and NK cells. In this issue of Immunity, Townsend et al. further define this relationship in terms of the transcription factor, T-bet.
openaire   +2 more sources

Differential location of NKT and MAIT cells within lymphoid tissue

Scientific Reports, 2022
Natural Killer T (NKT) cells and Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells that express semi-invariant αβ T cell receptors (TCRs) through which they recognise CD1d and MR1 molecules, respectively, in complex with specific ...
Darryl N. Johnson, Zheng Ruan, Emma V. Petley, Sapna Devi, Lauren E. Holz, Adam P. Uldrich, Jeffrey Y. W. Mak, Jyh Liang Hor, Scott N. Mueller, James McCluskey, David P. Fairlie, Phillip K. Darcy, Paul A. Beavis, William R. Heath, Dale I. Godfrey   +14 more
doaj   +1 more source

Histone demethylases UTX and JMJD3 are required for NKT cell development in mice

Cell & Bioscience, 2017
Background Natural killer (NK)T cells and conventional T cells share phenotypic characteristic however they differ in transcription factor requirements and functional properties.
Daniel Northrup, Ryoji Yagi, Kairong Cui, William R. Proctor, Chaochen Wang, Katarzyna Placek, Lance R. Pohl, Rongfu Wang, Kai Ge, Jinfang Zhu, Keji Zhao   +10 more
doaj   +1 more source

mTORC2 regulates multiple aspects of NKT‐cell development and function [PDF]

, 2017
Invariant NKT (iNKT) cells bridge innate and adaptive immunity by rapidly secreting cytokines and lysing targets following TCR recognition of lipid antigens.
Cotton, Renee M, Peng Guan, Sklarz, Tammarah, Das, Rupali, Angela Haczku, Rupali Das, Tammarah Sklarz, Mercy Gohil, Renee M. Cotton, Jordan, Martha S, Moyar Q. Ge, Martha S. Jordan, Gohil, Mercy, Ge, Moyar Q, Haczku, Angela, Guan, Peng   +15 more
core   +1 more source