Differential location of NKT and MAIT cells within lymphoid tissue
Scientific Reports, 2022 Natural Killer T (NKT) cells and Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells that express semi-invariant αβ T cell receptors (TCRs) through which they recognise CD1d and MR1 molecules, respectively, in complex with specific ...
Darryl N. Johnson +14 more
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Histone demethylases UTX and JMJD3 are required for NKT cell development in mice
Cell & Bioscience, 2017 Background Natural killer (NK)T cells and conventional T cells share phenotypic characteristic however they differ in transcription factor requirements and functional properties.
Daniel Northrup +10 more
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Global Analysis of Dynamic Epigenetic Marking and Transcriptional Regulation Underlying T-Cell Lineage Commitment [PDF]
, 2012 T-cell lineage specification and commitment success depends on precise temporal induction of T-lineage specific genes, as well as repression of lineage-inappropriate programs. After entry into the thymus, T-cell progenitors still retain inherited lineage
Zhang, Jingli A.
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Ameliorated ConA-induced hepatitis in the absence of PKC-theta. [PDF]
PLoS ONE, 2012 Severe liver injury that occurs when immune cells mistakenly attack an individual's own liver cells leads to autoimmune hepatitis. In mice, acute hepatitis can be induced by concanavalin A (ConA) treatment, which causes rapid activation of CD1d-positive ...
Xianfeng Fang +5 more
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New Directions for Natural Killer T Cells in the Immunotherapy of Cancer
Frontiers in Immunology, 2017 Natural killer T (NKT) cells have been placed at the interface between innate and adaptive immunity by a long series of experiments that convincingly showed that beyond cytokine secretion and NK cell recruitment, NKT cells were coordinating dendritic ...
Luc Teyton
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Activation of a Nonclassical NKT Cell Subset in a Transgenic Mouse Model of Hepatitis B Virus Infection [PDF]
, 2002 NKT cells are specialized cells of the immune system that bear both T cell and NK cell markers. Classical NKT cells display TCRs of restricted heterogeneity (Vα14-Jα281) and recognize lipid antigens (e.g., α-galactosyl ceramide) presented by ...
Gardiner, Leon +5 more
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Development of a deep learning-based 1D convolutional neural network model for cross-species natural killer T cell identification using peripheral blood mononuclear cell single-cell RNA sequencing data [PDF]
Veterinary WorldBackground and Aim: Natural killer T (NKT) cells exhibit the traits of both T and NK cells. Although their roles have been well studied in humans and mice, limited knowledge is available regarding their roles in dogs and pigs, which serve as models for ...
Kaj Chokeshaiusaha +3 more
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Natural Killer T and Natural Killer Cell-Based Immunotherapy Strategies Targeting Cancer
Biomolecules, 2023 Both natural killer T (NKT) and natural killer (NK) cells are innate cytotoxic lymphoid cells that produce inflammatory cytokines and chemokines, and their role in the innate immune response to tumors and microorganisms has been investigated. Especially,
Tomonori Iyoda +4 more
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The Role of Adaptor Proteins in the Biology of Natural Killer T (NKT) Cells
Frontiers in Immunology, 2019 Adaptor proteins contribute to the selection, differentiation and activation of natural killer T (NKT) cells, an innate(-like) lymphocyte population endowed with powerful immunomodulatory properties.
Evelyn Gerth, Jochen Mattner
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Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells. [PDF]
PLoS ONE, 2011 Natural killer T (NKT) cells represent an important regulatory T cell subset that develops in the thymus and contains immature (NK1.1(lo)) and mature (NK1.1(hi)) cell subsets.
Mehmet Yabas +3 more
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