Results 51 to 60 of about 30,886 (233)

B7-H1-deficiency enhances the potential of tolerogenic dendritic cells by activating CD1d-restricted type II NKT cells. [PDF]

PLoS ONE, 2010
BackgroundDendritic cells (DC) can act tolerogenic at a semi-mature stage by induction of protective CD4(+) T cell and NKT cell responses.Methodology/principal findingsHere we studied the role of the co-inhibitory molecule B7-H1 (PD-L1, CD274) on semi ...
Carolin Brandl, Sonja Ortler, Thomas Herrmann, Susanna Cardell, Manfred B Lutz, Heinz Wiendl   +5 more
doaj   +1 more source

Deterministic Nucleation of Nanocrystal Superlattices on 2D Perovskites for Light‐Funneling Heterostructures

Advanced Materials, EarlyView.
This work investigates the heterogeneous nucleation of CsPbBr3${\rm CsPbBr}_3$ nanocrystal superlattices along the faces of 2D PEA2PbBr4${\rm PEA}_2{\rm PbBr}_4$ layered perovskite microcrystals. Core–crown and core–shell heterostructure morphologies are obtained.
Umberto Filippi, Alexander Schleusener, Simone Lauciello, Roman Krahne, Dmitry Baranov, Liberato Manna, Masaru Kuno   +6 more
wiley   +1 more source

Cross-talk between cd1d-restricted nkt cells and γδ cells in t regulatory cell response

Virology Journal, 2011
CD1d is a non-classical major histocompatibility class 1-like molecule which primarily presents either microbial or endogenous glycolipid antigens to T cells involved in innate immunity.
Huber Sally A, Liu Wei
doaj   +1 more source

Intrinsic factors and CD1d1 but not CD1d2 expression levels control invariant natural killer T cell subset differentiation

Nature Communications, 2023
Invariant natural killer T (NKT) cell subsets are defined based on their cytokine-production profiles and transcription factors. Their distribution is different in C57BL/6 (B6) and BALB/c mice, with a bias for NKT1 and NKT2/NKT17 subsets, respectively ...
Ludivine Amable, Luis Antonio Ferreira Martins, Remi Pierre, Marcio Do Cruseiro, Ghita Chabab, Arnauld Sergé, Camille Kergaravat, Marc Delord, Christophe Viret, Jean Jaubert, Chaohong Liu, Saoussen Karray, Julien C. Marie, Magali Irla, Hristo Georgiev, Emmanuel Clave, Antoine Toubert, Bruno Lucas, Jihene Klibi, Kamel Benlagha   +19 more
doaj   +1 more source

Cross Talk Between Natural Killer T and Dendritic Cells and Its Impact on T Cell Responses in Infections

Frontiers in Immunology, 2022
Both innate and adaptive immunity is vital for host defense against infections. Dendritic cells (DCs) are critical for initiating and modulating adaptive immunity, especially for T-cell responses.
Lei Zhao, Lei Zhao, Xi Yang
doaj   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Natural Killer T Cell Function in Lymphoma Patients

Biomolecules
Natural killer T (NKT) cells bridge innate and adaptive immune responses and play a critical role in anti-tumor immunity. The goal of the study was to assess NKT cell and T cell function in lymphoma patients and to investigate whether specific cytokines ...
Roshanak Derakhshandeh, Michael S. Lee, Yuyi Zhu, Emmanuel B. Asiedu, Jocelyn Reader, Rania H. Younis, Amy S. Kimball, Nicole Glynn, Michael Kallen, Tonya J. Webb   +9 more
doaj   +1 more source

Natural Killer T Cell-Targeted Immunotherapy Mediating Long-term Memory Responses and Strong Antitumor Activity

Frontiers in Immunology, 2017
Current tumor therapies, including immunotherapies, focus on passive eradication or at least reduction of the tumor mass. However, cancer patients quite often suffer from tumor relapse or metastasis after such treatments.
Nyambayar Dashtsoodol, Nyambayar Dashtsoodol, Tomokuni Shigeura, Takuya Tashiro, Minako Aihara, Toshihiro Chikanishi, Hiromi Okada, Keigo Hanada, Hirokazu Sano, Akihiko Kurogi, Masaru Taniguchi   +10 more
doaj   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Discovery of NKT cells and development of NKT cell-targeted anti-tumor immunotherapy

Proceedings of the Japan Academy, Series B, 2015
Natural Killer T (NKT) cells are unique lymphocytes characterized by their expression of a single invariant antigen receptor encoded by Vα14Jα18 in mice and Vα24Jα18 in humans, which recognizes glycolipid antigens in association with the monomorphic CD1d molecule.
TANIGUCHI, Masaru, HARADA, Michishige, DASHTSOODOL, Nyambayar, KOJO, Satoshi   +3 more
openaire   +3 more sources