Results 51 to 60 of about 5,157 (213)

Development of a deep learning-based 1D convolutional neural network model for cross-species natural killer T cell identification using peripheral blood mononuclear cell single-cell RNA sequencing data [PDF]

Veterinary World
Background and Aim: Natural killer T (NKT) cells exhibit the traits of both T and NK cells. Although their roles have been well studied in humans and mice, limited knowledge is available regarding their roles in dogs and pigs, which serve as models for ...
Kaj Chokeshaiusaha, Thanida Sananmuang, Denis Puthier, Roongtham Kedkovid   +3 more
doaj   +1 more source

Osteopontin as a Mediator of NKT Cell Function in T Cell-Mediated Liver Diseases

, 2004
Both osteopontin (OPN) and natural killer T (NKT) cells play a role in the development of immunological disorders. We examined a functional link between OPN and NKT cells. Concanavalin A (Con A)-induced hepatitis is a well-characterized murine model of T
Uede, Toshimitsu, Ito, Daisuke, Segawa, Tatsuya, Taniguchi, Masaru, Toshimitsu Uede, Maeda, Masahiro, Kazunori Onóe, Morimoto, Junko, Kazuya Iwabuchi, Masaru Taniguchi, Luc Van Kaer, Rittling, Susan, David Denhardt, Hongyan Diao, Nakayama, Toshinori, Masahiro Maeda, Hamuro, Junji, Onóe, Kazunori, Chiemi Kimura, Diao, Hongyan, Shigeyuki Kon, Toshinori Nakayama, Yagita, Hideo, Junko Morimoto, Tatsuya Segawa, Hideo Yagita, Kon, Shigeyuki, Junji Hamuro, Iwabuchi, Kazuya, Daisuke Ito, Van Kaer, Luc, Kimura, Chiemi, Denhardt, David, Susan Rittling   +33 more
core   +1 more source

Neurofibromin 1 Impairs Natural Killer T-Cell-Dependent Antitumor Immunity against a T-Cell Lymphoma

Frontiers in Immunology, 2018
Neurofibromin 1 (NF1) is a tumor suppressor gene encoding a Ras GTPase that negatively regulates Ras signaling pathways. Mutations in NF1 are linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome.
Jianyun Liu, Richard M. Gallo, Masood A. Khan, Masood A. Khan, Gourapura J. Renukaradhya, Gourapura J. Renukaradhya, Randy R. Brutkiewicz   +6 more
doaj   +1 more source

Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells. [PDF]

PLoS ONE, 2011
Natural killer T (NKT) cells represent an important regulatory T cell subset that develops in the thymus and contains immature (NK1.1(lo)) and mature (NK1.1(hi)) cell subsets.
Mehmet Yabas, Dale I Godfrey, Christopher C Goodnow, Gerard F Hoyne   +3 more
doaj   +1 more source

NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells

, 2003
A major group of murine NK T (NKT) cells express an invariant Valpha14Jalpha18 TCR a-chain specific for glycolipid Ags presented by CD1d. Murine Valpha14alpha18(+) account for 30-50% of hepatic T cells and have potent antitumor activities.
Porcelli, SA, Kenna, T, Koezuka, Y, Golden-Mason, Lucy, Steven A. Porcelli, Tony Kenna, Mason, LG, O'Farrelly, C, Porcelli, Steven A., Hegarty, JE, John E. Hegarty, Koezuka, Yasuhiko, Doherty, DG, Cliona O’Farrelly, Derek G. Doherty, O'Farrelly, Cliona, Hegarty, John E., Kenna, Tony, Doherty, Derek G., Yasuhiko Koezuka, Lucy Golden Mason   +20 more
core   +1 more source

Mitochondria‐Damaging Self‐Reporting Probe for Cancer Therapy

Angewandte Chemie, EarlyView.
We developed a class of self‐reporting cationic chemotherapeutic probes that selectively induce mitochondrial damage and apoptosis in cancer cells. Their unique mitochondria‐to‐nucleus fluorescence migration enables real‐time visualization of the therapeutic process. ABSTRACT Mitochondrial damage induced by chemotherapeutic agents through disruption of
Hai Xu, Yura Lee, Sanghee Yoon, Yun Wang, Yejin Cho, Seongyu Choi, Lu Lu, Hua Zhang, Sun Choi, Ki Taek Nam, Juyoung Yoon   +10 more
wiley   +2 more sources

Recognition of lyso-phospholipids by human natural killer T lymphocytes.

PLoS Biology, 2009
Natural killer T (NKT) cells are a subset of T lymphocytes with potent immunoregulatory properties. Recognition of self-antigens presented by CD1d molecules is an important route of NKT cell activation; however, the molecular identity of specific ...
Lisa M Fox, Daryl G Cox, Jennifer L Lockridge, Xiaohua Wang, Xiuxu Chen, Louise Scharf, David L Trott, Rachel M Ndonye, Natacha Veerapen, Gurdyal S Besra, Amy R Howell, Mark E Cook, Erin J Adams, William H Hildebrand, Jenny E Gumperz   +14 more
doaj   +1 more source

Skewed distribution of circulating activated natural killer T (NKT) cells in patients with common variable immunodeficiency disorders (CVID). [PDF]

PLoS ONE, 2010
Common variable immunodeficiency disorder (CVID) is the commonest cause of primary antibody failure in adults and children, and characterized clinically by recurrent bacterial infections and autoimmune manifestations.
Karina I Carvalho, Karina M Melo, Fernanda R Bruno, Jennifer E Snyder-Cappione, Douglas F Nixon, Beatriz T Costa-Carvalho, Esper G Kallas   +6 more
doaj   +1 more source

Rapid Death and Regeneration of NKT Cells in Anti-CD3ε- or IL-12-Treated Mice A Major Role for Bone Marrow in NKT Cell Homeostasis

, 1998
Natural killer T (NKT) cells express a T cell receptor (TCR) and markers common to NK cells, including NK1.1. In vivo, NKT cells are triggered by anti-CD3ε MAb to rapidly produce large amounts of IL-4 and by IL-12 to reject tumors. We show here that anti-
Eberl, Gérard, Eberl, G., MacDonald, H.Robson, MacDonald, H.R.   +3 more
core   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source