Results 71 to 80 of about 30,886 (233)

Transcriptional regulation of the NKT cell lineage [PDF]

Current Opinion in Immunology, 2013
How expression of canonical semi-invariant TCRs leads to innate-like effector differentiation is a central enigma of NKT cell development. NKT thymic precursors undergo elevated TCR signals leading to increased Egr2, which directly induces their signature transcription factor, PLZF.
Michael G, Constantinides, Albert, Bendelac   +1 more
openaire   +2 more sources

High‐Efficiency Precipitate Recycling Strategy Paves the Way for Efficient Sb2S3 Solar Cells Fabricated by CBD Method

Advanced Science, EarlyView.
A novel PR strategy was proposed to improve CBD‐derived Sb2S3 film quality. It synergistically optimized the CBO of CdS/Sb2S3 interface and the back‐contact barrier, while the VS2 donor defect was converted into SSb2 acceptor defect with lower concentration.
Yeyang Lin, Zixian Cai, Mingen Zheng, Ye Huang, Weihuang Wang, Qiqiang Zhu, Qing Gao, Jianhui Chen, Shuying Cheng   +8 more
wiley   +1 more source

Label‐Free Myelin Fingerprinting: An Adult Human Post‐Mortem Brain Slice Platform via Coherent Anti‐Stokes Raman Spectroscopy

Advanced Science, EarlyView.
A serum‐free, air–liquid interface organotypic slice culture model preserves human post‐mortem corpus callosum tissue, successfully recovering from slicing trauma to reflect the donor's underlying disease state. Pairing label‐free Coherent anti‐Stokes Raman scattering (CARS) microscopy with k‐means clustering enables objective, high‐resolution ...
Kasra Roya‐Kouchaki, Jeroen P. Korterik, Femke Tjebbes, Geert J. Schenk, Herman L. Offerhaus, Antonio Luchicchi   +5 more
wiley   +1 more source

Cortical Thymocytes Along With Their Selecting Ligands Are Required for the Further Thymic Maturation of NKT Cells in Mice

Frontiers in Immunology, 2020
Following positive selection, NKT cell precursors enter an “NK-like” program and progress from an NK– to an NK+ maturational stage to give rise to NKT1 cells. Maturation takes place in the thymus or after emigration of NK– NKT cells to the periphery.
Jihene Klibi, Kamel Benlagha
doaj   +1 more source

Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice

Scientific Reports, 2021
The nuclear receptors liver X receptor α (LXRα) and LXRβ are lipid sensors that regulate lipid metabolism and immunity. Natural killer T (NKT) cells, a T cell subset expressing surface markers of both natural killer cells and T lymphocytes and involved ...
Kaori Endo-Umeda, Hiroyuki Nakashima, Shigeyuki Uno, Shota Toyoshima, Naoki Umeda, Shihoko Komine-Aizawa, Shuhji Seki, Makoto Makishima   +7 more
doaj   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

Temporal Regulation of Natural Killer T Cell Interferon Gamma Responses by β-Catenin-Dependent and -Independent Wnt Signaling

Frontiers in Immunology, 2018
Natural killer T (NKT) cells are prominent innate-like lymphocytes in the liver with critical roles in immune responses during infection, cancer, and autoimmunity.
Jessica C. Kling, Margaret A. Jordan, Lauren A. Pitt, Jana Meiners, Thao Thanh-Tran, Le Son Tran, Tam T. K. Nguyen, Deepak Mittal, Rehan Villani, Raymond J. Steptoe, Kiarash Khosrotehrani, Stuart P. Berzins, Stuart P. Berzins, Alan G. Baxter, Dale I. Godfrey, Dale I. Godfrey, Antje Blumenthal   +16 more
doaj   +1 more source

Ultralow‐Power Floating‐Gate InGaZnO Content‐Addressable Memory for Wearable Electrocardiogram Anomaly Detection

Advanced Intelligent Systems, EarlyView.
This study introduces a subthreshold in‐memory anomaly detection architecture for wearable ECG monitoring using floating‐gate IGZO content‐addressable memories on a flexible substrate. Area‐engineered coupling provides a high subthreshold slope, while subthreshold operation realizes intrinsic exponential distance evaluation and linear voltage sensing ...
Hyung‐Jun Noh, Sunyeol Bae, Yumin Yun, Junhyeong Park, Soo‐Yeon Lee   +4 more
wiley   +1 more source

An impact of type 2 diabetes mellitus on NKT-like cell population in humans: a new insight into impaired immune response in hyperglycemia

Frontiers in Endocrinology
BackgroundType 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by insulin resistance and pancreatic β-cell dysfunction. T2DM is associated with increased risk of infections and of several malignancies, although the underlying ...
Emilia Adamska-Fita, Przemysław Wiktor Śliwka, Przemysław Wiktor Śliwka, Bartłomiej Stasiak, Małgorzata Karbownik-Lewińska, Małgorzata Karbownik-Lewińska, Andrzej Lewiński, Andrzej Lewiński, Magdalena Stasiak   +8 more
doaj   +1 more source

Age‐associated immune dysregulation links to disease severity in macrolide‐resistant Mycoplasma pneumoniae pneumonia: Insights from a comparative juvenile–adult mouse model

Animal Models and Experimental Medicine, EarlyView.
Macrolide‐resistant Mycoplasma pneumoniae (MRMP) infected both juvenile and adult mice, with results compared to normal juvenile mice. The findings revealed comparable bacterial loads between juvenile and adult mice, yet juvenile mice exhibited more severe lung damage and elevated levels of inflammatory cytokines.
Xuejun Li, Yudong Wang, Liyong Liu, Mengmeng Gong, Jinlong Wang, Yuqing Cao, Zhixin Sun, Fanliang Meng, Qiuyan Wang, Hongji Wu, Fei Zhao, Yan Ma, Yibai Xiong   +12 more
wiley   +1 more source