Results 91 to 100 of about 5,262,931 (244)

Associations between CD56+ NK/NKT cell count and clinicopathological factors.

, 2016
Associations between CD56+ NK/NKT cell count and clinicopathological factors.
Anders Bjartell (199682), Jakob Eberhard (576483), Sebastian Lundgren (2825210), Carl Fredrik Warfvinge (2608102), Karin Jirström (133199), Agnieszka Krzyzanowska (2825207), Karin Leandersson (741824), Jacob Elebro (660943), Björn Nodin (576482), Margareta Heby (660946)   +9 more
core   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Translational control of NKT cell cytokine production by p38 MAPK

, 2016
NKT cells are known to rapidly produce a large amount of cytokines upon activation. Although a number of signaling pathways that regulate the development of NKT cells have been identified, the signaling pathways involved in the regulation of NKT cell ...
Nagaleekar, Viswas K., Benoit, Patrick J., Davis, Roger J., Chant, Alan, Sabio, Guadalupe, Rincon, Mercedes, Aktan, Idil, Thornton, Tina M., Boyson, Jonathan E., Howe, Isaac W.   +9 more
core   +1 more source

Image_2_SFRP4+IGFBP5hi NKT cells induced neural-like cell differentiation to contribute to adenomyosis pain.tiff

, 2022
BackgroundAdenomyosis is an estrogen-dependent gynecological disease. The pathogenesis of chronic pain, the main clinical symptom of adenomyosis, remains undefined.
Yichen Chen (4855573), Yuanyuan Shen (570328), Jing Zhang (23775), Liang Chen (73736), Jue Zhu (10957450), Qiming Wang (730892)   +5 more
core   +1 more source

Cortical Thymocytes Along With Their Selecting Ligands Are Required for the Further Thymic Maturation of NKT Cells in Mice

Frontiers in Immunology, 2020
Following positive selection, NKT cell precursors enter an “NK-like” program and progress from an NK– to an NK+ maturational stage to give rise to NKT1 cells. Maturation takes place in the thymus or after emigration of NK– NKT cells to the periphery.
Jihene Klibi, Kamel Benlagha
doaj   +1 more source

Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice

Scientific Reports, 2021
The nuclear receptors liver X receptor α (LXRα) and LXRβ are lipid sensors that regulate lipid metabolism and immunity. Natural killer T (NKT) cells, a T cell subset expressing surface markers of both natural killer cells and T lymphocytes and involved ...
Kaori Endo-Umeda, Hiroyuki Nakashima, Shigeyuki Uno, Shota Toyoshima, Naoki Umeda, Shihoko Komine-Aizawa, Shuhji Seki, Makoto Makishima   +7 more
doaj   +1 more source

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

Alterations in cellular metabolism modulate CD1d-mediated NKT-cell responses

, 2016
Natural killer T (NKT) cells play a critical role in the host's innate immune response. CD1d-mediated presentation of glycolipid antigens to NKT cells has been established; however, the mechanisms by which NKT cells recognize infected or cancerous cells ...
Brutkiewicz, Randy R., Sun, Wenji, Gregory B. Carey, James E. East, Webb, Tonya J., Randy R. Brutkiewicz, Amy S. Kimball, Carey, Gregory B., Tonya J. Webb, Dominique R. Bollino, Wenji Sun, East, James E., Bollino, Dominique R., Kimball, Amy S.   +13 more
core   +1 more source

Temporal Regulation of Natural Killer T Cell Interferon Gamma Responses by β-Catenin-Dependent and -Independent Wnt Signaling

Frontiers in Immunology, 2018
Natural killer T (NKT) cells are prominent innate-like lymphocytes in the liver with critical roles in immune responses during infection, cancer, and autoimmunity.
Jessica C. Kling, Margaret A. Jordan, Lauren A. Pitt, Jana Meiners, Thao Thanh-Tran, Le Son Tran, Tam T. K. Nguyen, Deepak Mittal, Rehan Villani, Raymond J. Steptoe, Kiarash Khosrotehrani, Stuart P. Berzins, Stuart P. Berzins, Alan G. Baxter, Dale I. Godfrey, Dale I. Godfrey, Antje Blumenthal   +16 more
doaj   +1 more source

Immune Biomarkers of Islet Transplant Rejection Revealed by Synthetic Immunological Niche

Advanced Science, EarlyView.
A subcutaneous synthetic immunological niche (IN) enables serial, minimally invasive monitoring of immune responses after islet transplantation. Flow cytometry and transcriptomic profiling of the IN reveal immune‐cell programs associated with graft acceptance and distinct types of rejection.
Jyotirmoy Roy, Abdalmonam Jadou Nejma, Mohammad Tarique, Amod Talekar, Shengli Wu, Brianna Ha, Yifei Jiang, Esma S. Yolcu, Lonnie D. Shea   +8 more
wiley   +1 more source