Results 91 to 100 of about 5,157 (213)

Border Patrol Gone Awry: Lung NKT Cell Activation by Francisella tularensis Exacerbates Tularemia-Like Disease. [PDF]

PLoS Pathogens, 2015
The respiratory mucosa is a major site for pathogen invasion and, hence, a site requiring constant immune surveillance. The type I, semi-invariant natural killer T (NKT) cells are enriched within the lung vasculature.
Timothy M Hill, Pavlo Gilchuk, Basak B Cicek, Maria A Osina, Kelli L Boyd, Douglas M Durrant, Dennis W Metzger, Kamal M Khanna, Sebastian Joyce   +8 more
doaj   +1 more source

NKT cell facts, functions and fallacies

, 2000
The proposed roles of NK1.1+ T (NKT) cells in immune responses range from suppression of autoimmunity to tumor rejection. Heterogeneity of these cells contributes to the controversy surrounding their development and function.
Hammond, Kirsten J. L., Baxter, Alan G., Smyth, Mark J., Dale I. Godfrey, Kirsten J.L. Hammond, Lynn D. Poulton, Alan G. Baxter, Poulton, Lynn D., Mark J. Smyth, Godfrey, Dale I.   +9 more
core   +1 more source

The making of NKT cells [PDF]

Nature Immunology, 2008
Natural killer T cells acquire their unique phenotype and characteristics during development in the thymus. Evidence suggests that the transcription factor PLZF has a unique function in the development of these cells and their acquisition of ‘innate-like’ characteristics.
openaire   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis

, 2009
Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis Background: The role of cytotoxicity of NKT-cells in the skin is not defined. There are two prototypic skin diseases in which epidermal Keratinocytes (KC) over-express CD1d, a
Balato, Anna
core  

The location of splenic NKT cells favours their rapid activation by blood-borne antigen.

, 2012
Natural killer T (NKT) cells play an important role in mounting protective responses to blood-borne infections. However, though the spleen is the largest blood filter in the body, the distribution and dynamics of NKT cells within this organ are not well ...
Batista, F.D., Cerundolo, Vincenzo, Barral, Patricia; id_orcid, Sánchez-Niño, MD, Sanchez-Nino, M.D., Cerundolo, V., Cerundolo, V, van Rooijen, N, Barral, P., Barral, P, van Rooijen, N., Batista, FD   +11 more
core   +1 more source

Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis

Exploration, EarlyView.
Smart nanodelivery systems deliver therapeutic payloads across the cartilage matrix to ensure their sustained accumulation within chondrocytes at sites of injury. By targeting specific molecular targets and signaling pathways, these platforms modulate the pathological synovium‐cartilage axis to restore immunometabolic homeostasis and drive tissue ...
Qirui Zhao, Zhewen Mi, Shuya Liu, Shijun Liang, Linjia Peng, Zixuan Gao, Jiaming Li, Xiaoqing Lu, Zhiguang Ren, Yongjie Wan, Shengsheng Cui, Longlong Lu, Xiaoyang Gao, Tao Wang, Hui Liang, Furong Tian, de la Fuente Jesus M, Chong Xiang, Luyi Sun, Lichen Xiang, Daxiang Cui   +20 more
wiley   +1 more source

An impact of type 2 diabetes mellitus on NKT-like cell population in humans: a new insight into impaired immune response in hyperglycemia

Frontiers in Endocrinology
BackgroundType 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by insulin resistance and pancreatic β-cell dysfunction. T2DM is associated with increased risk of infections and of several malignancies, although the underlying ...
Emilia Adamska-Fita, Przemysław Wiktor Śliwka, Przemysław Wiktor Śliwka, Bartłomiej Stasiak, Małgorzata Karbownik-Lewińska, Małgorzata Karbownik-Lewińska, Andrzej Lewiński, Andrzej Lewiński, Magdalena Stasiak   +8 more
doaj   +1 more source

Temporal Regulation of Natural Killer T Cell Interferon Gamma Responses by β-Catenin-Dependent and -Independent Wnt Signaling

Frontiers in Immunology, 2018
Natural killer T (NKT) cells are prominent innate-like lymphocytes in the liver with critical roles in immune responses during infection, cancer, and autoimmunity.
Jessica C. Kling, Margaret A. Jordan, Lauren A. Pitt, Jana Meiners, Thao Thanh-Tran, Le Son Tran, Tam T. K. Nguyen, Deepak Mittal, Rehan Villani, Raymond J. Steptoe, Kiarash Khosrotehrani, Stuart P. Berzins, Stuart P. Berzins, Alan G. Baxter, Dale I. Godfrey, Dale I. Godfrey, Antje Blumenthal   +16 more
doaj   +1 more source

Modulation of CD1d-restricted NKT cell responses by CD4

, 2007
CD4+ and CD4- NKT cell populations have been shown to be functionally distinct, but the role of CD4 molecules in NKT cell activation is not clear. Here, we have used human CD1d-restricted NKT cell clones to investigate the contribution of CD4 to NKT cell
Wang, X, Gumperz, JE, Besra, Gurdyal; id_orcid, Chen, X   +3 more
core   +1 more source