Results 81 to 90 of about 4,918,459 (222)

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

NKT cell facts, functions and fallacies

, 2000
The proposed roles of NK1.1+ T (NKT) cells in immune responses range from suppression of autoimmunity to tumor rejection. Heterogeneity of these cells contributes to the controversy surrounding their development and function.
Hammond, Kirsten J. L., Baxter, Alan G., Smyth, Mark J., Dale I. Godfrey, Kirsten J.L. Hammond, Lynn D. Poulton, Alan G. Baxter, Poulton, Lynn D., Mark J. Smyth, Godfrey, Dale I.   +9 more
core   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

The location of splenic NKT cells favours their rapid activation by blood-borne antigen.

, 2012
Natural killer T (NKT) cells play an important role in mounting protective responses to blood-borne infections. However, though the spleen is the largest blood filter in the body, the distribution and dynamics of NKT cells within this organ are not well ...
Batista, F.D., Cerundolo, Vincenzo, Barral, Patricia; id_orcid, Sánchez-Niño, MD, Sanchez-Nino, M.D., Cerundolo, V., Cerundolo, V, van Rooijen, N, Barral, P., Barral, P, van Rooijen, N., Batista, FD   +11 more
core   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Modulation of CD1d-restricted NKT cell responses by CD4

, 2007
CD4+ and CD4- NKT cell populations have been shown to be functionally distinct, but the role of CD4 molecules in NKT cell activation is not clear. Here, we have used human CD1d-restricted NKT cell clones to investigate the contribution of CD4 to NKT cell
Wang, X, Gumperz, JE, Besra, Gurdyal; id_orcid, Chen, X   +3 more
core   +1 more source

Ultralow‐Power Floating‐Gate InGaZnO Content‐Addressable Memory for Wearable Electrocardiogram Anomaly Detection

Advanced Intelligent Systems, EarlyView.
This study introduces a subthreshold in‐memory anomaly detection architecture for wearable ECG monitoring using floating‐gate IGZO content‐addressable memories on a flexible substrate. Area‐engineered coupling provides a high subthreshold slope, while subthreshold operation realizes intrinsic exponential distance evaluation and linear voltage sensing ...
Hyung‐Jun Noh, Sunyeol Bae, Yumin Yun, Junhyeong Park, Soo‐Yeon Lee   +4 more
wiley   +1 more source

HeaTrace: A Parametric Design‐to‐Fabrication Workflow for Thermally Programmable Soft Robots

Advanced Intelligent Systems, EarlyView.
A programmable thermal actuation workflow enables soft robots to be designed and fabricated with embedded heaters that drive multiple responses. By combining performance‐driven heater design with multimaterial fabrication, the system supports thermally triggered shape change, stiffness tuning, and thermochromic visual response, as demonstrated through ...
Naresh Kumar Thanigaivel, Thileepan Stalin, Elgar Kanhere, Aby Raj Plamootil Mathai, Konstantin Sakharov, Yong Lin, Hirusha Madhuwantha Loku Hettige, Gumawang Hiramandala, Shlomo Magdassi, Pablo Valdivia Y Alvarado   +9 more
wiley   +1 more source

Differential antitumor immunity mediated by NKT cell subsets in vivo [PDF]

, 2005
We showed previously that NKT cell-deficient TCR Jα18 mice are more susceptible to methylcholanthrene (MCA)-induced sarcomas, and that normal tumor surveillance can be restored by adoptive transfer of WT liver-derived NKT cells.
Godfrey, DI, Pellicci, DG, Coquet, JM, Kyparissoudis, K, Yoshihiro Hayakawa, Godfrey, Dale I., Hayakawa, Y, Stuart P. Berzins, Dale I. Godfrey, Hayakawa, Yoshihiro, Coquet, Jonathan M., Keating, Rachael, Smyth, MJ, Crowe, Nadine Y., Mark J. Smyth, Kyparissoudis, Konstantinos, Rachael Keating, Jonathan M. Coquet, Berzins, Stuart P., Berzins, SP, Konstantinos Kyparissoudis, Smyth, Mark J., Nadine Y. Crowe, Daniel G. Pellicci, Crowe, NY, Keating, R, Pellicci, Daniel G.   +26 more
core   +1 more source