Results 81 to 90 of about 5,157 (213)

Transcriptional regulation of the NKT cell lineage [PDF]

Current Opinion in Immunology, 2013
How expression of canonical semi-invariant TCRs leads to innate-like effector differentiation is a central enigma of NKT cell development. NKT thymic precursors undergo elevated TCR signals leading to increased Egr2, which directly induces their signature transcription factor, PLZF.
Michael G, Constantinides, Albert, Bendelac   +1 more
openaire   +2 more sources

Advances and perspectives in animal models of human hepatitis A virus

Animal Models and Experimental Medicine, EarlyView.
Following HAV infection, humans, non‐human primates, and Ifnar1−/− mice develop characteristic manifestations of hepatitis A, including fecal viral shedding, elevated serum ALT levels, and inflammatory cell infiltration in the liver. In contrast, HAV‐infected human liver chimeric mice exhibit fecal viral shedding but do not develop clinical features of
Jian Li, Pei‐Yu Jiang, Hui Zhao, Cheng‐Feng Qin   +3 more
wiley   +1 more source

Activation of a Nonclassical NKT Cell Subset in a Transgenic Mouse Model of Hepatitis B Virus Infection

, 2002
NKT cells are specialized cells of the immune system that bear both T cell and NK cell markers. Classical NKT cells display TCRs of restricted heterogeneity (Vα14-Jα281) and recognize lipid antigens (e.g., α-galactosyl ceramide) presented by ...
Gardiner, Leon, Baron, Jody L, Shinkai, Kanade, Locksley, Richard, Nishimura, Stephen, Ganem, Don   +5 more
core   +1 more source

Roquin Paralogs Differentially Regulate Functional NKT Cell Subsets

, 2017
NKT cells represent a small subset of glycolipid-recognizing T cells that are heavily implicated in human allergic, autoimmune, and malignant diseases. In the thymus, precursor cells recognize self-glycolipids by virtue of their semi-invariant TCR, which
Klaus D. Heger, F. Thomas Wunderlich, Sabrina Bortoluzzi, Julius C. Fischer, Marc Schmidt-Supprian, Christoph Drees, J. Christoph Vahl, Christian Peschel   +7 more
core   +2 more sources

Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis

Cell Reports, 2019
Summary: Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) proteins work in concert to regulate the levels of reactive oxygen species (ROS).
Kalyani Pyaram, Ajay Kumar, Yeung-Hyen Kim, Sanjeev Noel, Sekhar P. Reddy, Hamid Rabb, Cheong-Hee Chang   +6 more
doaj   +1 more source

Determinação dos valores de referência das populações linfocitárias em sangue periférico de indivíduos adultos [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2013Os resultados dos testes laboratoriais devem ser comparados o intervalo de referência com o objetivo ...
Oliveira, Renata Cristina Messores Rudolf de
core  

Integrated Clinical and Proteomic Profiling of CD19 CAR‐T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T‐cell therapy in patients with progressive systemic sclerosis. Methods Patients with progressive systemic sclerosis received CD19 CAR‐T cell therapy and were followed longitudinally for safety, clinical efficacy, immune ...
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Differential antitumor immunity mediated by NKT cell subsets in vivo [PDF]

, 2005
We showed previously that NKT cell-deficient TCR Jα18 mice are more susceptible to methylcholanthrene (MCA)-induced sarcomas, and that normal tumor surveillance can be restored by adoptive transfer of WT liver-derived NKT cells.
Godfrey, DI, Pellicci, DG, Coquet, JM, Kyparissoudis, K, Yoshihiro Hayakawa, Godfrey, Dale I., Hayakawa, Y, Stuart P. Berzins, Dale I. Godfrey, Hayakawa, Yoshihiro, Coquet, Jonathan M., Keating, Rachael, Smyth, MJ, Crowe, Nadine Y., Mark J. Smyth, Kyparissoudis, Konstantinos, Rachael Keating, Jonathan M. Coquet, Berzins, Stuart P., Berzins, SP, Konstantinos Kyparissoudis, Smyth, Mark J., Nadine Y. Crowe, Daniel G. Pellicci, Crowe, NY, Keating, R, Pellicci, Daniel G.   +26 more
core   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Cortical Thymocytes Along With Their Selecting Ligands Are Required for the Further Thymic Maturation of NKT Cells in Mice

Frontiers in Immunology, 2020
Following positive selection, NKT cell precursors enter an “NK-like” program and progress from an NK– to an NK+ maturational stage to give rise to NKT1 cells. Maturation takes place in the thymus or after emigration of NK– NKT cells to the periphery.
Jihene Klibi, Kamel Benlagha
doaj   +1 more source