Results 1 to 10 of about 35,995 (263)
Recognition of lyso-phospholipids by human natural killer T lymphocytes.
PLoS Biology, 2009 Natural killer T (NKT) cells are a subset of T lymphocytes with potent immunoregulatory properties. Recognition of self-antigens presented by CD1d molecules is an important route of NKT cell activation; however, the molecular identity of specific ...
Lisa M Fox +14 more
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Natural Killer T and Natural Killer Cell-Based Immunotherapy Strategies Targeting Cancer
Biomolecules, 2023 Both natural killer T (NKT) and natural killer (NK) cells are innate cytotoxic lymphoid cells that produce inflammatory cytokines and chemokines, and their role in the innate immune response to tumors and microorganisms has been investigated. Especially,
Tomonori Iyoda +4 more
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The Role of Adaptor Proteins in the Biology of Natural Killer T (NKT) Cells
Frontiers in Immunology, 2019 Adaptor proteins contribute to the selection, differentiation and activation of natural killer T (NKT) cells, an innate(-like) lymphocyte population endowed with powerful immunomodulatory properties.
Evelyn Gerth, Jochen Mattner
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Invariant NKT Cells as Novel Targets for Immunotherapy in Solid Tumors
Clinical and Developmental Immunology, 2012 Natural killer T (NKT) cells are a small population of lymphocytes that possess characteristics of both innate and adaptive immune cells. They are uniquely poised to respond rapidly to infection and inflammation and produce cytokines that critically ...
Karsten A. Pilones +2 more
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Regulation of NKT cell localization in homeostasis and infection
Frontiers in Immunology, 2015 Natural killer T (NKT) cells are a specialized subset of T lymphocytes that regulate immune responses in the context of autoimmunity, cancer, and microbial infection.
Drew eSlauenwhite +3 more
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Frontiers in Immunology, 2020 Following positive selection, NKT cell precursors enter an “NK-like” program and progress from an NK– to an NK+ maturational stage to give rise to NKT1 cells. Maturation takes place in the thymus or after emigration of NK– NKT cells to the periphery.
Jihene Klibi, Kamel Benlagha
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Differential location of NKT and MAIT cells within lymphoid tissue
Scientific Reports, 2022 Natural Killer T (NKT) cells and Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells that express semi-invariant αβ T cell receptors (TCRs) through which they recognise CD1d and MR1 molecules, respectively, in complex with specific ...
Darryl N. Johnson +14 more
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New Directions for Natural Killer T Cells in the Immunotherapy of Cancer
Frontiers in Immunology, 2017 Natural killer T (NKT) cells have been placed at the interface between innate and adaptive immunity by a long series of experiments that convincingly showed that beyond cytokine secretion and NK cell recruitment, NKT cells were coordinating dendritic ...
Luc Teyton
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Histone demethylases UTX and JMJD3 are required for NKT cell development in mice
Cell & Bioscience, 2017 Background Natural killer (NK)T cells and conventional T cells share phenotypic characteristic however they differ in transcription factor requirements and functional properties.
Daniel Northrup +10 more
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Differential inhibitory and activating NK cell receptor levels and NK/NKT-like cell functionality in chronic and recovered stages of chikungunya. [PDF]
PLoS ONE, 2017 The role of natural killer (NK; CD3-CD56+)/NKT (CD3+CD56+)-like cells in chikungunya virus (CHIKV) disease progression/recovery remains unclear.
Subrat Thanapati +2 more
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