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NKT Cell Responses to B Cell Lymphoma [PDF]
Medical Sciences, 2014 Natural killer T (NKT) cells are a unique subset of CD1d-restricted T lymphocytes that express characteristics of both T cells and natural killer cells.
Junxin Li +8 more
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Harnessing NKT cells for vaccination. [PDF]
Oxf Open Immunol, 2021 Lay Summary Vaccine-induced immune responses generally involve activation of immune cells called T and B cells that have a variety of mechanisms to limit the infection. Each T or B cell has a randomly generated receptor for binding pathogen-derived antigens, but only a few cells with an individual’s repertoire of cells will recognize a ...
Burn OK +4 more
europepmc +4 more sources
NKT Cells in Neurological Diseases [PDF]
Frontiers in Cellular Neuroscience, 2019 Natural killer T (NKT) cells are a unique subset of T lymphocytes with the expression of T cell receptor (TCR) and NK cell lineage receptors. These cells can rapidly release large quantities of cytokines and function as a bridge between innate and ...
Yu Cui, Qi Wan
doaj +3 more sources
NKT cells in the antitumor response: the β version? [PDF]
The Journal of Clinical InvestigationNKT cells recognize glycolipids presented by CD1d-expressing antigen-presenting cells (APCs) and include type I NKT cells with antitumor function and type II NKT cells, which have been reported to suppress the antitumor response.
Mitchell Kronenberg, Isaac Engel
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Mendelian Randomization and Transcriptomic Analysis Reveal the Protective Role of NKT Cells in Sepsis [PDF]
Journal of Inflammation ResearchQingxiang Liu,1,* Haitao Liu,2,* Zihan Hu,1 Xing Zhou,1 Kai Jin,1 Yingzi Huang,1 Wei Huang,1 Yi Yang1 1Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine ...
Liu Q +7 more
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SAP-Dependent and -Independent Regulation of Innate T Cell Development Involving SLAMF Receptors [PDF]
, 2014 Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) plays an essential role in the immune system mediating the function of several members of the SLAM family (SLAMF) of receptors, whose expression is essential for T, NK, and B-cell ...
De Calisto, Jaime +5 more
core +14 more sources
Regulation of NKT Cells by Ly49: Analysis of Primary NKT Cells and Generation of NKT Cell Line [PDF]
The Journal of Immunology, 2001 Abstract TCRαβ+NK1.1+ (NKT) cells are known to express various NK cell-associated molecules including the Ly49 family of receptors for MHC class I, but its functional significance has been unclear. Here, we examined the expression of Ly49A, C/I and G2 on various NKT cell populations from normal and MHC class I-deficient C57BL/6 mice as ...
M, Maeda +3 more
openaire +2 more sources
OncoImmunology, 2021 CD3+CD56+ NKT-like cells play pivotal roles in the anti-tumor immune defense response. However, little is known regarding circulating NKT-like cells in patients with primary hepatocellular carcinoma (HCC).
Longxiang Tao +7 more
doaj +1 more source
NKT cells in mucosal immunity [PDF]
Mucosal Immunology, 2009 The gastrointestinal tract allows the residence of an almost enumerable number of bacteria. To maintain homeostasis, the mucosal immune system must remain tolerant to the commensal microbiota and eradicate pathogenic bacteria. Aberrant interactions between the mucosal immune cells and the microbiota have been implicated in the pathogenesis of ...
Middendorp, Sabine, Nieuwenhuis, EES
openaire +2 more sources
Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions. [PDF]
PLoS ONE, 2006 Natural killer T (NKT) cells are a subset of T cells that help potentiate and regulate immune responses. Although human NKT cell subsets with distinct effector functions have been identified, it is unclear whether the effector functions of these subsets ...
Karla A Eger +5 more
doaj +1 more source