Results 21 to 30 of about 35,995 (263)

IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production [PDF]

The Journal of Immunology, 2007
The common γ-chain cytokine, IL-21, is produced by CD4 T cells and mediates potent effects on a variety of immune cells including NK, T, and B cells. NKT cells express the receptor for IL-21; however, the effect of this cytokine on NKT cell function has ...
Godfrey, DI, Coquet, JM, Kyparissoudis, K, Besra, Gurdyal; id_orcid, Smyth, MJ, Besra, Gurdyal, Godfrey, Dale I., Kyparissoudis, Konstantinos, Berzins, Stuart P., Berzins, SP, Smyth, Mark J., Pellici, DG, Coquet, Jonathan M., Pellicci, Daniel G.   +13 more
core   +6 more sources

NKT cells in cardiovascular diseases

European Journal of Pharmacology, 2017
Despite life-style advice and the prescription of cholesterol-lowering and anti-thrombotic drugs, cardiovascular diseases are still the leading cause of death worldwide.
Gijs H.M. van Puijvelde, Kuiper, J., Johan Kuiper, Puijvelde, G.H.M. van   +3 more
core   +5 more sources

Efficient isolation of mouse liver NKT cells by perfusion. [PDF]

PLoS ONE, 2010
BACKGROUND: NKT cell is a population of unconventional T cells that mediate both innate and adaptive T cell responses. Since NKT cells are most abundant in the liver, much of NKT biology has been learnt from studies of NKT cells isolated from liver. This
Xianfeng Fang, Peishuang Du, Yang Liu, Jie Tang   +3 more
doaj   +2 more sources

Type II NKT Cells: An Elusive Population With Immunoregulatory Properties

Frontiers in Immunology, 2018
Natural killer T (NKT) cells are unique unconventional T cells that are reactive to lipid antigens presented on the non-polymorphic major histocompatibility class (MHC) I-like molecule CD1d.
Avadhesh Kumar Singh, Prabhanshu Tripathi, Susanna L. Cardell   +2 more
doaj   +2 more sources

Inflammatory Phenotype of Intrahepatic Sulfatide-Reactive Type II NKT Cells in Humans With Autoimmune Hepatitis

Frontiers in Immunology, 2019
Background: Natural Killer T (NKT) cells are CD1d-restricted innate-like T cells that can rapidly release stored cytokines upon recognition of lipid antigens. In mice, type I NKT cells seem to promote liver inflammation, whereas type II NKT cells seem to
Marcial Sebode, Marcial Sebode, Jennifer Wigger, Pamela Filpe, Lutz Fischer, Sören Weidemann, Till Krech, Christina Weiler-Normann, Christina Weiler-Normann, Christina Weiler-Normann, Moritz Peiseler, Moritz Peiseler, Johannes Hartl, Johannes Hartl, Eva Tolosa, Johannes Herkel, Christoph Schramm, Christoph Schramm, Christoph Schramm, Ansgar W. Lohse, Ansgar W. Lohse, Philomena Arrenberg   +21 more
doaj   +3 more sources

Working with NKT cells - Pitfalls and practicalities

Current Opinion in Immunology, 2005
Our understanding of NKT cells has been rapidly advancing over recent years, with many research groups studying how these cells behave and how they can be manipulated to prevent disease. Although good progress has been made, a difficulty is the lack of a
Berzins, Stuart P., Smyth, Mark J., Godfrey, Dale I.   +2 more
core   +5 more sources

Mendelian Randomization and Transcriptomic Analysis Reveal the Protective Role of NKT Cells in Sepsis [PDF]

Journal of Inflammation Research
Qingxiang Liu,1,* Haitao Liu,2,* Zihan Hu,1 Xing Zhou,1 Kai Jin,1 Yingzi Huang,1 Wei Huang,1 Yi Yang1 1Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine ...
Liu Q, Liu H, Hu Z, Zhou X, Jin K, Huang Y, Huang W, Yang Y   +7 more
doaj   +2 more sources

Harnessing NKT cells for vaccination. [PDF]

Oxf Open Immunol, 2021
Lay Summary Vaccine-induced immune responses generally involve activation of immune cells called T and B cells that have a variety of mechanisms to limit the infection. Each T or B cell has a randomly generated receptor for binding pathogen-derived antigens, but only a few cells with an individual’s repertoire of cells will recognize a ...
Burn OK, Pankhurst TE, Painter GF, Connor LM, Hermans IF.   +4 more
europepmc   +4 more sources

Regulation of NKT Cells by Ly49: Analysis of Primary NKT Cells and Generation of NKT Cell Line [PDF]

The Journal of Immunology, 2001
Abstract TCRαβ+NK1.1+ (NKT) cells are known to express various NK cell-associated molecules including the Ly49 family of receptors for MHC class I, but its functional significance has been unclear. Here, we examined the expression of Ly49A, C/I and G2 on various NKT cell populations from normal and MHC class I-deficient C57BL/6 mice ...
M, Maeda, S, Lohwasser, T, Yamamura, F, Takei   +3 more
openaire   +2 more sources

PD-1 blockade improves the anti-tumor potency of exhausted CD3+CD56+ NKT-like cells in patients with primary hepatocellular carcinoma

OncoImmunology, 2021
CD3+CD56+ NKT-like cells play pivotal roles in the anti-tumor immune defense response. However, little is known regarding circulating NKT-like cells in patients with primary hepatocellular carcinoma (HCC).
Longxiang Tao, Shanshan Wang, Guijie Kang, Shanyue Jiang, Wenwei Yin, Lu Zong, Jing Li, Xuefu Wang   +7 more
doaj   +1 more source