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Regulation of NKT Cells by Ly49: Analysis of Primary NKT Cells and Generation of NKT Cell Line [PDF]
The Journal of Immunology, 2001 Abstract TCRαβ+NK1.1+ (NKT) cells are known to express various NK cell-associated molecules including the Ly49 family of receptors for MHC class I, but its functional significance has been unclear. Here, we examined the expression of Ly49A, C/I and G2 on various NKT cell populations from normal and MHC class I-deficient C57BL/6 mice ...
M, Maeda +3 more
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OncoImmunology, 2021 CD3+CD56+ NKT-like cells play pivotal roles in the anti-tumor immune defense response. However, little is known regarding circulating NKT-like cells in patients with primary hepatocellular carcinoma (HCC).
Longxiang Tao +7 more
doaj +1 more source
Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions. [PDF]
PLoS ONE, 2006 Natural killer T (NKT) cells are a subset of T cells that help potentiate and regulate immune responses. Although human NKT cell subsets with distinct effector functions have been identified, it is unclear whether the effector functions of these subsets ...
Karla A Eger +5 more
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Identification of CD4(-)CD8(-) double-negative natural killer T cell precursors in the thymus. [PDF]
PLoS ONE, 2008 BACKGROUND: It is well known that CD1d-restricted Valpha14 invariant natural killer T (NKT) cells are derived from cells in the CD4(+)CD8(+) double-positive (DP) population in the thymus. However, the developmental progression of NKT cells in the earlier
Nyambayar Dashtsoodol +3 more
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The interaction between regulatory T cells and NKT cells in the liver: a CD1d bridge links innate and adaptive immunity. [PDF]
PLoS ONE, 2011 Regulatory T cells (Tregs) and natural killer T (NKT) cells are two distinct lymphocyte subsets that independently regulate hepatic adaptive and innate immunity, respectively.
Jing Hua +5 more
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Cord blood Vα24-Vβ11 natural killer T cells display a Th2-chemokine receptor profile and cytokine responses. [PDF]
PLoS ONE, 2011 BACKGROUND: The fetal immune system is characterized by a Th2 bias but it is unclear how the Th2 predominance is established. Natural killer T (NKT) cells are a rare subset of T cells with immune regulatory functions and are already activated in utero ...
Susanne Harner +7 more
doaj +1 more source
NKT cells in mucosal immunity [PDF]
Mucosal Immunology, 2009 The gastrointestinal tract allows the residence of an almost enumerable number of bacteria. To maintain homeostasis, the mucosal immune system must remain tolerant to the commensal microbiota and eradicate pathogenic bacteria. Aberrant interactions between the mucosal immune cells and the microbiota have been implicated in the pathogenesis of ...
Middendorp, Sabine, Nieuwenhuis, EES
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Clinical & developmental immunology, 2010 Sepsis is currently a leading cause of death in hospital intensive care units. Previous studies suggest that the pathophysiology of sepsis involves the hyperactivation of complex proinflammatory cascades that include the activation of various immune cells and the exuberant secretion of proinflammatory cytokines by these cells.
Leung, Briana, Harris, Hobart W
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Frontiers in Immunology, 2018 Natural killer T (NKT) cells are a unique T cell subset that exhibits characteristics from both the innate immune cells and T cells. There are at least two subsets of NKT cells, type I and type II.
Shingo Kato +2 more
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Immunobiology, 2017 The role of NKT cells in the resistance or susceptibility towards Leishmania infections remains to be defined, since controversial data persist. The response of these cells seems to depend on many variables such as the infection site, the number of infecting parasites, the virulence of the strain and the Leishmania species.
Jaime, Zamora-Chimal +2 more
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