Results 21 to 30 of about 58,157 (254)

EBV promotes human CD8 NKT cell development. [PDF]

PLoS Pathogens, 2010
The reports on the origin of human CD8(+) Valpha24(+) T-cell receptor (TCR) natural killer T (NKT) cells are controversial. The underlying mechanism that controls human CD4 versus CD8 NKT cell development is not well-characterized.
Yuling He, Ruijing Xiao, Xiang Ji, Li Li, Lang Chen, Jie Xiong, Wei Xiao, Yujuan Wang, Lijun Zhang, Rui Zhou, Xinti Tan, Yongyi Bi, Yan-Ping Jiang, Youxin Jin, Jinquan Tan   +14 more
doaj   +1 more source

Single-Cell RNA-Seq Analysis Uncovers Distinct Functional Human NKT Cell Sub-Populations in Peripheral Blood

Frontiers in Cell and Developmental Biology, 2020
Vα24-invariant human natural killer T (NKT) cells comprise a unique subset of CD1d-restricted T cells with potent immune regulatory function and are involved in the development of a variety of human diseases.
Li Zhou, Li Zhou, Indra Adrianto, Jie Wang, Jie Wang, Xiaojun Wu, Xiaojun Wu, Indrani Datta, Qing-Sheng Mi, Qing-Sheng Mi   +9 more
doaj   +1 more source

Alterations in cellular metabolism modulate CD1d-mediated NKT-cell responses [PDF]

, 2016
Natural killer T (NKT) cells play a critical role in the host's innate immune response. CD1d-mediated presentation of glycolipid antigens to NKT cells has been established; however, the mechanisms by which NKT cells recognize infected or cancerous cells ...
Bollino, Dominique R., Brutkiewicz, Randy R., Carey, Gregory B., East, James E., Kimball, Amy S., Sun, Wenji, Webb, Tonya J.   +6 more
core   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

The Influence of Invariant Natural Killer T Cells on Humoral Immunity to T-Dependent and -Independent Antigens

Frontiers in Immunology, 2018
Vaccination with CD1d-binding glycolipid adjuvants and co-administered protein, lipid, and carbohydrate antigens leads to invariant natural killer T (NKT) cell-dependent enhancement of protective B cell responses.
Mark L. Lang
doaj   +1 more source

Skewed distribution of circulating activated natural killer T (NKT) cells in patients with common variable immunodeficiency disorders (CVID). [PDF]

PLoS ONE, 2010
Common variable immunodeficiency disorder (CVID) is the commonest cause of primary antibody failure in adults and children, and characterized clinically by recurrent bacterial infections and autoimmune manifestations.
Karina I Carvalho, Karina M Melo, Fernanda R Bruno, Jennifer E Snyder-Cappione, Douglas F Nixon, Beatriz T Costa-Carvalho, Esper G Kallas   +6 more
doaj   +1 more source

Detection of natural killer T cells in mice infected with Rickettsia conorii [PDF]

, 2013
Little information is available regarding the role of natural killer T (NKT) cells during the early stage of Rickettsia conorii infection. Herein, C3H/HeN mice were infected with the Malish 7 strain of R. conorii.
Agnone, A., Alongi, A., Blanda, V., Caracappa, S., Di Marco, V., Dieli, F., Giudice, E., LA MANNA, M., Sireci, G., Torina, A.   +9 more
core   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Critical role of NKT cells in posttransplant alloantibody production [PDF]

, 2014
We previously reported that posttransplant alloantibody production in CD8-deficient hosts is IL-4+ CD4+ T cell-dependent and IgG1 isotype-dominant. The current studies investigated the hypothesis that IL-4-producing natural killer T cells (NKT cells ...
Abdel-Rasoul, M., Brutkiewicz, R. R., Bumgardner, G. L., Elzein, S. M., Sanghavi, P. B., Swamy, P., Wright, C. L., Zimmerer, J. M.   +7 more
core   +1 more source

CD3+CD56+ natural killer T cell infiltration is increased in cervical cancer and negatively correlated with tumour progression

Biotechnology & Biotechnological Equipment, 2019
This study investigated the phenotype and function of natural killer T (NKT) cells infiltrating cervical cancer tissues, in an attempt to understand the regulation of NKT cells by cervical cancer cells.
Yunxia Tu, Mei Pan, Shuhong Song, Jinren Hua, Rongfang Liu, Longyu Li   +5 more
doaj   +1 more source