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Unraveling Natural Killer T-Cells Development [PDF]
Frontiers in Immunology, 2018 Natural killer T-cells are a subset of innate-like T-cells with the ability to bridge innate and adaptive immunity. There is great interest in harnessing these cells to improve tumor therapy; however, greater understanding of invariant NKT (iNKT) cell ...
Sabrina Bianca Bennstein
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Natural killer cells and natural killer T cells in Lyme arthritis [PDF]
Arthritis Research & Therapy, 2013 Introduction: Natural killer (NK) and natural killer T (NKT) cells provide a first line of defense against infection. However, these cells have not yet been examined in patients with Lyme arthritis, a late disease manifestation.
Drouin, Elise E +2 more
core +6 more sources
Invariant Natural Killer T Cells [PDF]
Antibodies, 2013 Invariant Natural killer T cell (iNKT cells) are a subset of T cells, which are narrowly defined as a T cell lineage expressing a semi-invariant CD1d-restricted T cell Receptors (TCRs) composed by Vα24-Jα18/Vβ11 in human, and Vα14-Jα18/Vβ8,Vβ7, and Vβ2 ...
Antonella Cianferoni
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Invariant natural killer T cells in lung diseases [PDF]
Experimental and Molecular Medicine, 2023 Invariant natural killer T (iNKT) cells are a subset of T cells that are characterized by a restricted T-cell receptor (TCR) repertoire and a unique ability to recognize glycolipid antigens.
Dongjin Jeong +2 more
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Natural Killer T Cells in Cancer Immunotherapy [PDF]
Frontiers in Immunology, 2017 Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid antigens. Following stimulation, NKT cells lead to downstream activation of both innate and adaptive immune cells in the tumor microenvironment.
Shiny Nair, Madhav V. Dhodapkar
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Natural killer T cells (NK T cells) functions in malignancies
Asian Pacific Journal of Cancer Biology, 2018 CD1d-restricted natural killer (NKT) cells are unique innate like T lymphocyte that recognize glycolipid antigens. Two major NKT cell subsets, type I and type II, are different in their TCR repertoire and ligand specificity.
Sima balouchi-anaraki, Marzie Norouzian
doaj +5 more sources
Immunometabolic Activation of Invariant Natural Killer T Cells [PDF]
Frontiers in Immunology, 2018 Invariant natural killer T (iNKT) cells are lipid-reactive T cells with profound immunomodulatory potential. They are unique in their restriction to lipid antigens presented in CD1d molecules, which underlies their role in lipid-driven disorders such as ...
Francesca A. Ververs +7 more
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Differential activation of killer cells in the circulation and the lung: a study of current smoking status and chronic obstructive pulmonary disease (COPD) [PDF]
, 2013 Background:CD8+ T-lymphocytes, natural killer T-like cells (NKT-like cells, CD56+CD3+) and natural killer cells (NK cells, CD56+CD3−) are the three main classes of human killer cells and they are implicated in the pathogenesis of chronic obstructive ...
Corne, Jonathan M. +5 more
core +14 more sources
Targeting Natural Killer T Cells in Solid Malignancies
Cells, 2021 Natural killer T (NKT) cells are a unique subset of lymphocytes that recognize lipid antigens in the context of the non-classical class I MHC molecule, CD1d, and serve as a link between the innate and adaptive immune system through their expeditious ...
Zewde Ingram +6 more
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