Results 11 to 20 of about 247,672 (311)
Targeting natural killer cells and natural killer T cells in cancer [PDF]
Nature Reviews Immunology, 2012 Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share some phenotypical and functional similarities. Both cell types can rapidly respond to the presence of tumour cells and participate in antitumour immune responses. This has prompted interest in the development of innovative cancer therapies that are based on
Eric Vivier +2 more
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Invariant natural killer T cells in lung diseases [PDF]
Experimental and Molecular Medicine, 2023 Invariant natural killer T (iNKT) cells are a subset of T cells that are characterized by a restricted T-cell receptor (TCR) repertoire and a unique ability to recognize glycolipid antigens.
Dongjin Jeong +2 more
doaj +2 more sources
Unraveling Natural Killer T-Cells Development [PDF]
Frontiers in Immunology, 2018 Natural killer T-cells are a subset of innate-like T-cells with the ability to bridge innate and adaptive immunity. There is great interest in harnessing these cells to improve tumor therapy; however, greater understanding of invariant NKT (iNKT) cell ...
Sabrina Bianca Bennstein
doaj +3 more sources
Natural Killer T Cells in Cancer Immunotherapy [PDF]
Frontiers in Immunology, 2017 Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid antigens. Following stimulation, NKT cells lead to downstream activation of both innate and adaptive immune cells in the tumor microenvironment.
Shiny Nair, Madhav V. Dhodapkar
doaj +3 more sources
Stimulation of Natural Killer T Cells by Glycolipids [PDF]
Molecules, 2013 Natural killer T (NKT) cells are a subset of T cells that recognize glycolipid antigens presented by the CD1d protein. The initial discovery of immunostimulatory glycolipids from a marine sponge and the T cells that respond to the compounds has led to ...
Brian L. Anderson +3 more
doaj +3 more sources
Regulatory role of natural killer T cells in diabetes
Biomedical Journal, 2015 Type 1 and type 2 diabetes are growing public health problems. Despite having different pathophysiologies, both diseases are associated with defects in immune regulation.
Celine Tard +2 more
doaj +5 more sources
Targeting Natural Killer T Cells in Solid Malignancies
Cells, 2021 Natural killer T (NKT) cells are a unique subset of lymphocytes that recognize lipid antigens in the context of the non-classical class I MHC molecule, CD1d, and serve as a link between the innate and adaptive immune system through their expeditious ...
Zewde Ingram +6 more
doaj +1 more source
T-cell dysfunction in natural killer/T-cell lymphoma
OncoImmunology, 2023 Natural killer/T-cell lymphoma (NKTCL) is an incurable aggressive T-cell lymphoma closely correlated with Epstein‒Barr virus (EBV) infection. Chronic and consistent viral infection induces T-cell exhaustion. Herein, we describe T-cell dysfunction in NKTCL patients for the first time.
Xiaoyan Feng +8 more
openaire +3 more sources
Natural killer T cells (NK T cells) functions in malignancies
Asian Pacific Journal of Cancer Biology, 2018 CD1d-restricted natural killer (NKT) cells are unique innate like T lymphocyte that recognize glycolipid antigens. Two major NKT cell subsets, type I and type II, are different in their TCR repertoire and ligand specificity.
Sima balouchi-anaraki, Marzie Norouzian
doaj +3 more sources