Results 11 to 20 of about 6,334 (213)
Stimulation of Natural Killer T Cells by Glycolipids [PDF]
Molecules, 2013 Natural killer T (NKT) cells are a subset of T cells that recognize glycolipid antigens presented by the CD1d protein. The initial discovery of immunostimulatory glycolipids from a marine sponge and the T cells that respond to the compounds has led to ...
Brian L. Anderson +3 more
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T-cell dysfunction in natural killer/T-cell lymphoma
OncoImmunology, 2023 Natural killer/T-cell lymphoma (NKTCL) is an incurable aggressive T-cell lymphoma closely correlated with Epstein‒Barr virus (EBV) infection. Chronic and consistent viral infection induces T-cell exhaustion. Herein, we describe T-cell dysfunction in NKTCL patients for the first time.
Xiaoyan Feng +8 more
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Natural killer cells and natural killer T cells in Lyme arthritis [PDF]
Arthritis Research & Therapy, 2013 Abstract Introduction Natural killer (NK) and natural killer T (NKT) cells provide a first line of defense against infection. However, these cells have not yet been examined in patients with Lyme arthritis, a late disease manifestation. Lyme arthritis usually resolves with antibiotic treatment.
Katchar, Kia +2 more
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Natural Killer T Cell Diversity and Immunotherapy
Cancers, 2023 Invariant natural killer T cells (iNKTs), a type of unconventional T cells, share features with NK cells and have an invariant T cell receptor (TCR), which recognizes lipid antigens loaded on CD1d molecules, a major histocompatibility complex class I (MHC-I)-like protein.
Eduardo I. Tognarelli +7 more
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Natural killer and natural killer T cells in liver fibrosis
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013 The liver lymphocyte population is enriched with natural killer (NK) cells, which play a key role in host defense against viral infection and tumor transformation. Recent evidence from animal models suggests that NK cells also play an important role in inhibiting liver fibrosis by selectively killing early or senescence activated hepatic stellate cells
Gao, Bin, Radaeva, Svetlana
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Immunoregulation of Autoimmunity by Natural Killer T Cells [PDF]
Human Immunology, 2005 Natural killer T (NKT) cells are a conserved subpopulation of lymphocytes that recognize glycolipid antigens in a CD1d context. Upon activation through their semi-invariant T cell receptor, these cells rapidly release large amounts of immunomodulating Th1 and Th2 cytokines.
Loes, Linsen +2 more
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T cell regulation of natural killer cells [PDF]
Journal of Experimental Medicine, 2013 In light of their role in the immune response against tumors and viruses, natural killer (NK) cells represent a promising target for immunotherapy. Before this target is reached, the various mechanisms that control NK cell activity must first be identified and understood.
Kerdiles, Yann +2 more
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Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections
Frontiers in Immunology, 2018 The immune system has been traditionally divided into two arms called innate and adaptive immunity. Typically, innate immunity refers to rapid defense mechanisms that set in motion within minutes to hours following an insult.
François Trottein +6 more
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Epstein–Barr Virus-Specific Immune Control by Innate Lymphocytes
Frontiers in Immunology, 2017 Epstein–Barr virus (EBV) is a potent B cell transforming pathogen in humans. In most persistently EBV-infected individuals, potent cytotoxic lymphocyte responses prevent EBV-associated pathologies.
Christian Münz
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