Results 31 to 40 of about 366,533 (301)

Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro.

PLoS ONE, 2019
Glioblastoma is the leading malignant glioma with a poor prognosis. This study aimed to investigate the antitumor effects of natural killer cells in combination with temozolomide as the standard chemotherapeutic agent for glioblastoma.
Yoshitaka Tanaka, Tsutomu Nakazawa, Mitsutoshi Nakamura, Fumihiko Nishimura, Ryosuke Matsuda, Koji Omoto, Yoichi Shida, Toshiharu Murakami, Ichiro Nakagawa, Yasushi Motoyama, Hiromichi Morita, Takahiro Tsujimura, Hiroyuki Nakase   +12 more
doaj   +1 more source

Epstein–Barr Virus-Specific Immune Control by Innate Lymphocytes

Frontiers in Immunology, 2017
Epstein–Barr virus (EBV) is a potent B cell transforming pathogen in humans. In most persistently EBV-infected individuals, potent cytotoxic lymphocyte responses prevent EBV-associated pathologies.
Christian Münz
doaj   +1 more source

Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology [PDF]

, 2014
Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T ...
Husain, Zaheed, Seth, Pankaj, Sukhatme, Vikas P   +2 more
core   +1 more source

Stimulation of Natural Killer T Cells by Glycolipids

Molecules, 2013
Natural killer T (NKT) cells are a subset of T cells that recognize glycolipid antigens presented by the CD1d protein. The initial discovery of immunostimulatory glycolipids from a marine sponge and the T cells that respond to the compounds has led to ...
Brian L. Anderson, Luc Teyton, Albert Bendelac, Paul B. Savage   +3 more
doaj   +1 more source

New cell sources for CAR-based immunotherapy

Biomarker Research, 2023
Chimeric antigen receptor (CAR) T cell therapy, in which a patient’s own T lymphocytes are engineered to recognize and kill cancer cells, has achieved striking success in some hematological malignancies in preclinical and clinical trials, resulting in ...
Marzieh Mazinani, Fatemeh Rahbarizadeh
doaj   +1 more source

Natural Killer T Cell Diversity and Immunotherapy

Cancers, 2023
Invariant natural killer T cells (iNKTs), a type of unconventional T cells, share features with NK cells and have an invariant T cell receptor (TCR), which recognizes lipid antigens loaded on CD1d molecules, a major histocompatibility complex class I (MHC-I)-like protein.
Eduardo I. Tognarelli, Cristián Gutiérrez-Vera, Pablo A. Palacios, Ignacio A. Pasten-Ferrada, Fernanda Aguirre-Muñoz, Daniel A. Cornejo, Pablo A. González, Leandro J. Carreño   +7 more
openaire   +2 more sources

Immune mediated autologous cytotoxicity against hematopoietic precursor cells in patients with myelodysplastic syndrome

Haematologica, 2009
Background An activated immune system has been observed in patients with myelodysplastic syndrome but its exact contribution to disease development and control is not fully clarified.
Martine E.D. Chamuleau, Theresia M. Westers, Linda van Dreunen, Judith Groenland, Adri Zevenbergen, Corien M. Eeltink, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht   +7 more
doaj   +1 more source

Impact of NKG2D Signaling on Natural Killer and T‐Cell Function in Cerebral Ischemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Typically defined as a thromboinflammatory disease, ischemic stroke features early and delayed inflammatory responses, which determine the extent of ischemia‐related brain damage.
Christina David, Tobias Ruck, Leoni Rolfes, Stine Mencl, Peter Kraft, Michael K. Schuhmann, Christina B. Schroeter, Robin Jansen, Friederike Langhauser, Anne K. Mausberg, Anke C. Fender, Sven G. Meuth, Christoph Kleinschnitz   +12 more
doaj   +1 more source

A team effort: natural killer cells on the first leg of the tumor immunity relay race [PDF]

, 2018
Recent work by Böttcher and colleagues defines a new role for Natural Killer cells in the anti-tumor immune response, arriving early into the tumor microenvironment before passing the baton to DC1 dendritic cells.
Duong, Ellen, Fessenden, Timothy B, Spranger-Zimmermann, Stefani   +2 more
core   +1 more source

Topographical Distribution and Spatial Interactions of Innate and Semi-Innate Immune Cells in Pancreatic and Other Periampullary Adenocarcinoma

Frontiers in Immunology, 2020
BackgroundThe clinical management of pancreatic and other periampullary neoplasms remains challenging. In contrast to other cancer types, immunotherapies are largely ineffective, and the reason for the deprived immune response and the immune inhibiting ...
Sebastian Lundgren, Patrick Micke, Jacob Elebro, Margareta Heby, Ina Hrynchyk, Björn Nodin, Karin Leandersson, Artur Mezheyeuski, Karin Jirström   +8 more
doaj   +1 more source