Results 21 to 30 of about 6,334 (213)

Natural Killer T Cell Based Immunotherapy [PDF]

Journal of Vaccines & Vaccination, 2012
Natural killer T (NKT) cells play an important immunoregulatory role and are thought to bridge the innate and adaptive immune responses. Following activation through cognate interactions with lipid antigen presented in the context of CD1d molecules, NKT cells rapidly produce a plethora of cytokines and can also mediate cytotoxicity. Due to their potent
Priyanka B, Subrahmanyam, Wenji, Sun, James E, East, Junxin, Li, Tonya J, Webb   +4 more
openaire   +2 more sources

Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro.

PLoS ONE, 2019
Glioblastoma is the leading malignant glioma with a poor prognosis. This study aimed to investigate the antitumor effects of natural killer cells in combination with temozolomide as the standard chemotherapeutic agent for glioblastoma.
Yoshitaka Tanaka, Tsutomu Nakazawa, Mitsutoshi Nakamura, Fumihiko Nishimura, Ryosuke Matsuda, Koji Omoto, Yoichi Shida, Toshiharu Murakami, Ichiro Nakagawa, Yasushi Motoyama, Hiromichi Morita, Takahiro Tsujimura, Hiroyuki Nakase   +12 more
doaj   +1 more source

Natural killer or natural killer/T cell lineage large granular lymphocytosis associated with dasatinib therapy for Philadelphia chromosome positive leukemia

Haematologica, 2009
Dasatinib, a dual tyrosine kinase inhibitor, is known to modulate or suppress T-cell activation and proliferation. We report a series of 8 patients who developed chronic peripheral lymphocytosis, identified as natural killer cells or natural killer/T ...
Dong Hwan Kim, Suzanne Kamel-Reid, Hong Chang, Robert Sutherland, Chul Won Jung, Hyeoung-Joon Kim, Je-Jung Lee, Jeffrey H. Lipton   +7 more
doaj   +1 more source

New cell sources for CAR-based immunotherapy

Biomarker Research, 2023
Chimeric antigen receptor (CAR) T cell therapy, in which a patient’s own T lymphocytes are engineered to recognize and kill cancer cells, has achieved striking success in some hematological malignancies in preclinical and clinical trials, resulting in ...
Marzieh Mazinani, Fatemeh Rahbarizadeh
doaj   +1 more source

Natural killer T cells and the regulation of asthma [PDF]

Mucosal Immunology, 2009
A crucial role has been suggested for invariant natural killer T cells (iNKT) in regulating the development of asthma, a complex and heterogeneous disease characterized by airway inflammation and airway hyperreactivity (AHR). iNKT cells constitute a unique subset of T cells responding to endogenous and exogenous lipid antigens, rapidly secreting a ...
P, Matangkasombut, M, Pichavant, R H, Dekruyff, D T, Umetsu   +3 more
openaire   +2 more sources

Immune mediated autologous cytotoxicity against hematopoietic precursor cells in patients with myelodysplastic syndrome

Haematologica, 2009
Background An activated immune system has been observed in patients with myelodysplastic syndrome but its exact contribution to disease development and control is not fully clarified.
Martine E.D. Chamuleau, Theresia M. Westers, Linda van Dreunen, Judith Groenland, Adri Zevenbergen, Corien M. Eeltink, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht   +7 more
doaj   +1 more source

The role of NK and NKT cells in the pathogenesis and improvement of multiple sclerosis following disease‐modifying therapies

Health Science Reports, 2022
Background Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS) that T cells become autoreactive by recognizing CNS antigens. Both innate and adaptive immune systems are involved in the pathogenesis of MS.
Alireza Ahmadi, Zahra Fallah Vastani, Mahdi Abounoori, Mahdieh Azizi, Alireza Labani‐Motlagh, Sajad Mami, Sanaz Mami   +6 more
doaj   +1 more source

Highly activated and expanded natural killer cells for multiple myeloma immunotherapy

Haematologica, 2012
Background Patients with gene expression profiling-defined high-risk myeloma in relapse have poor outcomes with current therapies. We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound ...
Tarun K. Garg, Susann M. Szmania, Junaid A. Khan, Antje Hoering, Paul A. Malbrough, Amberly Moreno-Bost, Amy D. Greenway, Joshuah D. Lingo, Xin Li, Shmuel Yaccoby, Larry J. Suva, Brian Storrie, Guido Tricot, Dario Campana, John D. Shaughnessy, Bijay P. Nair, William T. Bellamy, Joshua Epstein, Bart Barlogie, Frits van Rhee   +19 more
doaj   +1 more source

Topographical Distribution and Spatial Interactions of Innate and Semi-Innate Immune Cells in Pancreatic and Other Periampullary Adenocarcinoma

Frontiers in Immunology, 2020
BackgroundThe clinical management of pancreatic and other periampullary neoplasms remains challenging. In contrast to other cancer types, immunotherapies are largely ineffective, and the reason for the deprived immune response and the immune inhibiting ...
Sebastian Lundgren, Patrick Micke, Jacob Elebro, Margareta Heby, Ina Hrynchyk, Björn Nodin, Karin Leandersson, Artur Mezheyeuski, Karin Jirström   +8 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source