Results 41 to 50 of about 5,685,226 (248)

Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis [PDF]

, 2009
Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis Background: The role of cytotoxicity of NKT-cells in the skin is not defined. There are two prototypic skin diseases in which epidermal Keratinocytes (KC) over-express CD1d, a
Balato, Anna
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Efficient isolation of mouse liver NKT cells by perfusion. [PDF]

PLoS ONE, 2010
BACKGROUND: NKT cell is a population of unconventional T cells that mediate both innate and adaptive T cell responses. Since NKT cells are most abundant in the liver, much of NKT biology has been learnt from studies of NKT cells isolated from liver. This
Xianfeng Fang, Peishuang Du, Yang Liu, Jie Tang   +3 more
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Natural killer T cells from peripheral blood of patients with pregnancy-induced hypertension inhibit the proliferation and migration of vascular endothelial cells by secreting interleukin-17

Biotechnology & Biotechnological Equipment, 2019
The aim of this study was to investigate the phenotype and function of NKT cells and the effect of NKT cells on the functions of vascular endothelial cells. The study included 30 pregnant women with hypertension and 20 pregnant women with normal delivery.
Aixin Zhao, Kun Liu, Yunfang Qi
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Phenotypic characterization of CD8+NKT cells [PDF]

European Journal of Immunology, 2000
We describe a novel CD8(+)NKT cell population expressing TCRalpha /beta or TCRgamma /delta. These CD8(+)NKT cells were prominent in the liver, and except for the thymus, virtually absent in other lymphoid organs. CD8(+)NKT cells expressed activation markers and comprised a high proportion of Ly49(+) cells.
Emoto, M., Zerrahn, J., Miyamoto, M., Perarnau, B., Kaufmann, S.   +4 more
openaire   +3 more sources

NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome

, 2021
NKT cells comprise three subsets—type I (invariant, iNKT), type II, and NKT-like cells, of which iNKT cells are the most studied subset. They are capable of rapid cytokine production after the initial stimulus, thus they may be important for polarisation
Michał K. Zarobkiewicz, Agnieszka Bojarska-Junak, Izabela Morawska, Adam Michalski, Jacek Roliński   +4 more
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New ways to turn on NKT cells [PDF]

, 2011
Natural killer T (NKT) cells are CD1d-restricted, lipid antigen–reactive T cells with powerful immunoregulatory potential. The prototypic antigen for NKT cells is a marine sponge–derived glycolipid, α-galactosylceramide (α-GalCer), but this is not ...
Godfrey, DI, Jamie Rossjohn, Rossjohn, J, Dale Ian Godfrey   +3 more
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CD1d-restricted NKT cells: an interstrain comparison [PDF]

, 2001
CD1d-restricted Va14-Ja281 invariant abTCR1 (NKT) cells are well defined in the C57BL/6 mouse strain, but they remain poorly characterized in non-NK1.1-expressing strains.
Naidenko, Olga V., Godfrey, Dale I., Olga V. Naidenko, Hammond, Kirsten J. L., Kirsten J. L. Hammond, Baxter, Alan G., Dale I. Godfrey, Scalzo, Anthony A., Daniel G. Pellicci, Lynn D. Poulton, Alan G. Baxter, Pellicci, Daniel G., Poulton, Lynn D., Anthony A. Scalzo   +13 more
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Cortical Thymocytes Along With Their Selecting Ligands Are Required for the Further Thymic Maturation of NKT Cells in Mice

Frontiers in Immunology, 2020
Following positive selection, NKT cell precursors enter an “NK-like” program and progress from an NK– to an NK+ maturational stage to give rise to NKT1 cells. Maturation takes place in the thymus or after emigration of NK– NKT cells to the periphery.
Jihene Klibi, Kamel Benlagha
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Differential location of NKT and MAIT cells within lymphoid tissue

, 2022
Natural Killer T (NKT) cells and Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells that express semi-invariant αβ T cell receptors (TCRs) through which they recognise CD1d and MR1 molecules, respectively, in complex with specific ...
Fairlie, DP, Godfrey, DI, Hor, JL, Darcy, PK, Beavis, PA, Uldrich, AP, Mak, JYW, Petley, EV, Heath, WR, Mueller, SN, Ruan, Z, Devi, S, Holz, LE, Johnson, DN, McCluskey, J, Sapna Devi, Emma V. Petley, Dale I. Godfrey, Jeffrey Y. W. Mak, Lauren E. Holz, Jyh Liang Hor, Adam P. Uldrich, Zheng Ruan, William R. Heath, Paul A. Beavis, Scott N. Mueller, Phillip K. Darcy, James McCluskey, David P. Fairlie, Darryl N. Johnson   +29 more
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NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells

, 2003
A major group of murine NK T (NKT) cells express an invariant Valpha14Jalpha18 TCR a-chain specific for glycolipid Ags presented by CD1d. Murine Valpha14alpha18(+) account for 30-50% of hepatic T cells and have potent antitumor activities.
Porcelli, SA, Kenna, T, Koezuka, Y, Golden-Mason, Lucy, Steven A. Porcelli, Tony Kenna, Mason, LG, O'Farrelly, C, Porcelli, Steven A., Hegarty, JE, John E. Hegarty, Koezuka, Yasuhiko, Doherty, DG, Cliona O’Farrelly, Derek G. Doherty, O'Farrelly, Cliona, Hegarty, John E., Kenna, Tony, Doherty, Derek G., Yasuhiko Koezuka, Lucy Golden Mason   +20 more
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