Natural Killer T Cells Are Numerically and Functionally Deficient in Patients with Trauma
Journal of Innate Immunity, 2020 Natural killer T (NKT) cells rapidly produce Th1 and Th2 cytokines such as interferon-γ (IFN-γ) and interleukin (IL)-4. This study examined the frequency and function of NKT cells in trauma patients.
Young-Goun Jo +5 more
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Type II NKT cells: a distinct CD1d-restricted immune regulatory NKT cell subset [PDF]
Immunogenetics, 2016 Type II natural killer T cells (NKT) are a subset of the innate-like CD1d-restricted lymphocytes that are reactive to lipid antigens. Unlike the type I NKT cells, which express a semi-invariant TCR, type II NKT cells express a broader TCR repertoire. Additionally, other features, such as their predominance over type I cells in humans versus mice, the ...
Suryasarathi, Dasgupta, Vipin, Kumar
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Biotechnology & Biotechnological Equipment, 2019 The aim of this study was to investigate the phenotype and function of NKT cells and the effect of NKT cells on the functions of vascular endothelial cells. The study included 30 pregnant women with hypertension and 20 pregnant women with normal delivery.
Aixin Zhao, Kun Liu, Yunfang Qi
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Tailored design of NKT-stimulatory glycolipids for polarization of immune responses. [PDF]
, 2017 Natural killer T (NKT) cell is a distinct population of T lymphocytes that can rapidly release massive amount of Th1 and Th2 cytokines upon the engagement of their T cell receptor with glycolipids presented by CD1d.
Huang, Jing-Rong +2 more
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CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides
Frontiers in Immunology, 2018 NKT cells belong to a distinct subset of T cells that recognize hydrophobic antigens presented by major histocompatibility complex class I-like molecules, such as CD1d.
Yusuke Nishioka +3 more
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A comprehensive ex vivo functional analysis of human NKT cells reveals production of MIP1-α and MIP1-β, a lack of IL-17, and a Th1-bias in males. [PDF]
PLoS ONE, 2010 NKT cells contribute to the modulation of immune responses and are believed to be important in the pathogenesis of autoimmune and infectious diseases, as well as cancer.
Jennifer E Snyder-Cappione +6 more
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Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis [PDF]
, 2017 Chronic lymphocytic leukemia (CLL) is characterized by the expansion of malignant CD5(+) B lymphocytes in blood, bone marrow and lymphoid organs. CD1d-restricted invariant Natural Killer T (iNKT) cells are innate-like T lymphocytes strongly implicated in
Azzimonti, Laura +17 more
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Type II NKT Cells: An Elusive Population With Immunoregulatory Properties
Frontiers in Immunology, 2018 Natural killer T (NKT) cells are unique unconventional T cells that are reactive to lipid antigens presented on the non-polymorphic major histocompatibility class (MHC) I-like molecule CD1d.
Avadhesh Kumar Singh +2 more
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Efficient isolation of mouse liver NKT cells by perfusion. [PDF]
PLoS ONE, 2010 BACKGROUND: NKT cell is a population of unconventional T cells that mediate both innate and adaptive T cell responses. Since NKT cells are most abundant in the liver, much of NKT biology has been learnt from studies of NKT cells isolated from liver. This
Xianfeng Fang +3 more
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Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling [PDF]
, 2018 Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with
Andrews, Paul S. +8 more
core +5 more sources