Results 51 to 60 of about 58,157 (254)
OncoImmunology, 2023 Malignant pleural effusion (MPE) is a functional ‘cold’ tumor microenvironment in which the antitumor activity of CD8+ T cells and natural killer T (NKT)-like cells is suppressed and the function of regulatory T (Treg) cells is enhanced.
Zi-Hao Wang +10 more
doaj +1 more source
NKT Cells Contribute to the Control of Microbial Infections
Frontiers in Cellular and Infection Microbiology, 2021 Innate (-like) T lymphocytes such as natural killer T (NKT) cells play a pivotal role in the recognition of microbial infections and their subsequent elimination.
Stefan Vogt +2 more
doaj +1 more source
Ninjurin 1 contributes to TLR-induced inflammation in endothelial cells [PDF]
, 2012 Background: Nerve injury induced protein 1 (Ninjurin 1 (Ninj1)) was first identified in Schwann cells and neurons contributing to cell adhesion and nerve regeneration.
Jennewein, Carla, Zacharowski, Kai
core +1 more source
MAIT cells come to the rescue in cancer immunotherapy? [PDF]
, 2020 Recent progress in immunobiology has led to the observation that, among cells classically categorized as the typical representatives of the adaptive immune system, i.e., T cells, some possess the phenotype of innate cells.
Elewaut, Dirk +2 more
core +2 more sources
OncoImmunology, 2013 Although invariant natural killer T (iNKT) cells influence antitumor responses indirectly by secreting cytokines and promoting the cytolytic functions of T and NK cells, we find that iNKT cells mediate direct tumoricidal activity in vitro and significantly inhibit tumor growth in vivo, even in the absence of other cytotoxic lymphocytes.
Bassiri, Hamid +2 more
openaire +2 more sources
Recognition of lyso-phospholipids by human natural killer T lymphocytes.
PLoS Biology, 2009 Natural killer T (NKT) cells are a subset of T lymphocytes with potent immunoregulatory properties. Recognition of self-antigens presented by CD1d molecules is an important route of NKT cell activation; however, the molecular identity of specific ...
Lisa M Fox +14 more
doaj +1 more source
Genetic Regulation of NKT Cell Function [PDF]
, 2017 NKT cells are specialized T cells that play important roles in the host immune response to bacteria and viruses. NKT cells produce a wide variety of cytokines and chemokines after being activated by glycolipids such as α-galactosylceramide (αGalCer ...
Malagic, Murisa
core +1 more source
Role of CD44 and its v7 isoform in staphylococcal enterotoxin B-induced toxic shock : CD44 deficiency on hepatic mononuclear cells leads to reduced activation-induced apoptosis that results in increased liver damage [PDF]
, 2005 Exposure to bacterial superantigens such as staphylococcal enterotoxin B (SEB) leads to the induction of toxic shock syndrome which results in multiorgan failure, including liver damage.
McKallip, R. J. +5 more
core +1 more source
PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source
Role of NKT Cells during Viral Infection and the Development of NKT Cell-Based Nanovaccines
Vaccines, 2021 Natural killer T (NKT) cells, a small population of T cells, are capable of influencing a wide range of the immune cells, including T cells, B cells, dendritic cells and macrophages.
Masood Alam Khan, Arif Khan
doaj +1 more source