Results 61 to 70 of about 35,995 (263)
OncoImmunology, 2023 Malignant pleural effusion (MPE) is a functional ‘cold’ tumor microenvironment in which the antitumor activity of CD8+ T cells and natural killer T (NKT)-like cells is suppressed and the function of regulatory T (Treg) cells is enhanced.
Zi-Hao Wang +10 more
doaj +1 more source
NKT Cells Contribute to the Control of Microbial Infections
Frontiers in Cellular and Infection Microbiology, 2021 Innate (-like) T lymphocytes such as natural killer T (NKT) cells play a pivotal role in the recognition of microbial infections and their subsequent elimination.
Stefan Vogt +2 more
doaj +1 more source
, 2003 A major group of murine NK T (NKT) cells express an invariant Valpha14Jalpha18 TCR a-chain specific for glycolipid Ags presented by CD1d. Murine Valpha14alpha18(+) account for 30-50% of hepatic T cells and have potent antitumor activities.
Porcelli, SA +20 more
core +1 more source
Advanced Functional Materials, EarlyView.Solvent vapor annealing enables kinetic control of additive‐free morphology in organic solar cells. Selective plasticization of acceptor forms an optimal fibrillar network, boosting efficiency to 19.06% (binary) and 19.75% (ternary), with ultrafast exciton dissociation and reduced recombination.
Jie Lv +20 more
wiley +1 more source
Mitochondria‐Damaging Self‐Reporting Probe for Cancer Therapy
Angewandte Chemie, EarlyView.We developed a class of self‐reporting cationic chemotherapeutic probes that selectively induce mitochondrial damage and apoptosis in cancer cells. Their unique mitochondria‐to‐nucleus fluorescence migration enables real‐time visualization of the therapeutic process. ABSTRACT Mitochondrial damage induced by chemotherapeutic agents through disruption of
Hai Xu +10 more
wiley +2 more sources
Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy
Advanced Healthcare Materials, EarlyView.Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima +15 more
wiley +1 more source
Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes [PDF]
, 2013 Protective responses to microorganisms involve the nonspecific but rapid defence mechanisms of the innate immune system, followed by the specific but slow defence mechanisms of the adaptive immune system. Located as sentinels at the interface between the
Cols, M +5 more
core +1 more source
Minimally Invasive Delivery of Optical Nanosensors Using Injectable Hydrogels
Advanced Materials Interfaces, EarlyView.Injectable peptide hydrogels offer a minimally invasive delivery platform for single‐walled carbon nanotube (SWCNT)‐based near‐infrared fluorescent sensors, enabling real‐time measurement of drug concentrations. Encapsulated SWCNTs show a dose‐dependent fluorescence response across physiologically relevant concentrations and retain their fluorescence ...
Shirel Kleiner, Gili Bisker
wiley +1 more source
, 2008 AIM: To determine the immunomodulatory effect of Shiitake (a mushroom extract), we tested its effect on liver-mediated immune regulation in a model of immune-mediated colitis. METHODS: Four groups of mice were studied. Colitis was induced by intracolonic
Hershcovici, T. +11 more
core +1 more source
PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source