Results 81 to 90 of about 58,157 (254)

Invariant NKT Cells as Novel Targets for Immunotherapy in Solid Tumors

Clinical and Developmental Immunology, 2012
Natural killer T (NKT) cells are a small population of lymphocytes that possess characteristics of both innate and adaptive immune cells. They are uniquely poised to respond rapidly to infection and inflammation and produce cytokines that critically ...
Karsten A. Pilones, Joseph Aryankalayil, Sandra Demaria   +2 more
doaj   +1 more source

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

Advanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang, Siqi Guo, Jing Li, Qianqian Huang, Jing Ning, Binbin Xia, Xun Lv, Xiang Liu, Zeyu Gao, Jine Li, Longchao Liu, Moshi Song, Jun Wang   +12 more
wiley   +1 more source

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Differential location of NKT and MAIT cells within lymphoid tissue

Scientific Reports, 2022
Natural Killer T (NKT) cells and Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells that express semi-invariant αβ T cell receptors (TCRs) through which they recognise CD1d and MR1 molecules, respectively, in complex with specific ...
Darryl N. Johnson, Zheng Ruan, Emma V. Petley, Sapna Devi, Lauren E. Holz, Adam P. Uldrich, Jeffrey Y. W. Mak, Jyh Liang Hor, Scott N. Mueller, James McCluskey, David P. Fairlie, Phillip K. Darcy, Paul A. Beavis, William R. Heath, Dale I. Godfrey   +14 more
doaj   +1 more source

Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function [PDF]

, 2018
MHC class I-like CD1 molecules have evolved to present lipid-based antigens to T cells. Differences in the antigen-binding clefts of the CD1 family members determine the conformation and size of the lipids that are presented, although the factors that ...
Bradbury, Brossay, Chen, Crosby, Deng, Gurdyal S. Besra, Hughes, Ichimiya, Jamie Rossjohn, Jennifer L. Matsuda, Jingjing Zhang, Jérôme Le Nours, Kathryn D. Tuttle, Laurent Gapin, Natacha Veerapen, Park, Romain Bedel, S. Harsha Krovi, Srinivasan Sundararaj, T. Praveena, Yogesh Khandokar, Zajonc, Zhang   +22 more
core   +4 more sources

Surface Plasmon Enhanced Photoluminescence of Carbon Dots Formed In Situ on Silver Gratings

Advanced Science, EarlyView.
Carbon emitters formed in situ on a silver grating via plasmonic catalysis yield enhanced spontaneous emission by preferential radiative decay into surface plasmons. Enhancement manifests as emission exhibiting characteristics of coherence (polarization, directionality), and accelerated lifetimes of ∼30 ps, yielding Purcell factors of ∼70.
Maryam Sadat Amiri Naeini, Jaspreet Walia, Luis Angel Mayoral‐Astorga, Hyung Woo Choi, Arnaud Weck, Pierre Berini   +5 more
wiley   +1 more source

New Directions for Natural Killer T Cells in the Immunotherapy of Cancer

Frontiers in Immunology, 2017
Natural killer T (NKT) cells have been placed at the interface between innate and adaptive immunity by a long series of experiments that convincingly showed that beyond cytokine secretion and NK cell recruitment, NKT cells were coordinating dendritic ...
Luc Teyton
doaj   +1 more source

Border patrol gone awry: Lung NKT cell activation by Francisella tularensis exacerbates tularemia-like disease [PDF]

, 2015
The respiratory mucosa is a major site for pathogen invasion and, hence, a site requiring constant immune surveillance. The type I, semi-invariant natural killer T (NKT) cells are enriched within the lung vasculature.
Boyd, Kelli L, Cicek, Basak B, Durrant, Douglas M, Gilchuk, Pavlo, Hill, Timothy M, Joyce, Sebastian, Khanna, Kamal M, Metzger, Dennis W, Osina, Maria A   +8 more
core   +5 more sources

Transcriptomic and Neuroimaging Decoding of Brain‐Immune Crosstalk in Thyroid Eye Disease

Advanced Science, EarlyView.
This study employed an imaging transcriptomics framework integrating resting‐state fMRI with Allen Human Brain Atlas transcriptomic data, coupled with peripheral blood RNA sequencing, to decode brain‐immune crosstalk in thyroid eye disease. Frontal, parietal, subcortical, and brainstem regions were identified as key neuroimmune‐ vulnerable regions ...
Haiyang Zhang, Yuting Liu, Shufan Jiang, Zilin Fang, Mengda Jiang, Xiaofeng Tao, Tianyi Zhu, Jipeng Li, Sijie Fang, Xuefei Song, Yinwei Li, Jing Sun, Chuanjun Tong, Zhengrun Gao, Huifang Zhou, Xianqun Fan   +15 more
wiley   +1 more source

Cortical Thymocytes Along With Their Selecting Ligands Are Required for the Further Thymic Maturation of NKT Cells in Mice

Frontiers in Immunology, 2020
Following positive selection, NKT cell precursors enter an “NK-like” program and progress from an NK– to an NK+ maturational stage to give rise to NKT1 cells. Maturation takes place in the thymus or after emigration of NK– NKT cells to the periphery.
Jihene Klibi, Kamel Benlagha
doaj   +1 more source