Results 81 to 90 of about 5,685,226 (248)

Transcriptional regulation of the NKT cell lineage [PDF]

Current Opinion in Immunology, 2013
How expression of canonical semi-invariant TCRs leads to innate-like effector differentiation is a central enigma of NKT cell development. NKT thymic precursors undergo elevated TCR signals leading to increased Egr2, which directly induces their signature transcription factor, PLZF.
Michael G, Constantinides, Albert, Bendelac   +1 more
openaire   +2 more sources

Immune Biomarkers of Islet Transplant Rejection Revealed by Synthetic Immunological Niche

Advanced Science, EarlyView.
A subcutaneous synthetic immunological niche (IN) enables serial, minimally invasive monitoring of immune responses after islet transplantation. Flow cytometry and transcriptomic profiling of the IN reveal immune‐cell programs associated with graft acceptance and distinct types of rejection.
Jyotirmoy Roy, Abdalmonam Jadou Nejma, Mohammad Tarique, Amod Talekar, Shengli Wu, Brianna Ha, Yifei Jiang, Esma S. Yolcu, Lonnie D. Shea   +8 more
wiley   +1 more source

NK/NKT Cells and Aging

, 2007
SUMMARYAging involves a complex physiologic process including a decline of immune function that may contribute to morbidity and mortality due to increased susceptibility to infection, cancer, and other immune-related dis-eases.
Yu-Jen Chen, Hui-Fen Liao
core   +1 more source

Recognition of lyso-phospholipids by human natural killer T lymphocytes.

PLoS Biology, 2009
Natural killer T (NKT) cells are a subset of T lymphocytes with potent immunoregulatory properties. Recognition of self-antigens presented by CD1d molecules is an important route of NKT cell activation; however, the molecular identity of specific ...
Lisa M Fox, Daryl G Cox, Jennifer L Lockridge, Xiaohua Wang, Xiuxu Chen, Louise Scharf, David L Trott, Rachel M Ndonye, Natacha Veerapen, Gurdyal S Besra, Amy R Howell, Mark E Cook, Erin J Adams, William H Hildebrand, Jenny E Gumperz   +14 more
doaj   +1 more source

Laser‐Induced Rashba Spin‐Orbit Torques in Multiferroic Semiconductor (Ge,Mn)Te

Advanced Science, EarlyView.
Femtosecond optical excitation generates two distinct effective spin–orbit torques in the multiferroic semiconductor (Ge,Mn)Te. Photoinduced holes drive coherent magnetization precession through a subpicosecond shift of the easy axis, while changes in ferroelectric sublattice displacements modify magnetic ordering via the Rashba interaction.
Zeynab Sadeghi, Tomáš Ostatnický, Eva Schmoranzerová, Jozef Kimák, Dominik Kriegner, Helena Reichlová, Lukáš Nádvorník, Gunther Springholz, J. Hugo Dil, Juraj Krempasky, Petr Němec   +10 more
wiley   +1 more source

Role of NKT Cells in the Pathogenesis of NAFLD [PDF]

, 2012
Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease and shows various inflammatory changes in the liver. Among those inflammatory cells, natural killer T (NKT) cells are found to have a critical role during the disease ...
Yukihiro Shimizu, Kazuto Tajiri
core   +1 more source

HeaTrace: A Parametric Design‐to‐Fabrication Workflow for Thermally Programmable Soft Robots

Advanced Intelligent Systems, EarlyView.
A programmable thermal actuation workflow enables soft robots to be designed and fabricated with embedded heaters that drive multiple responses. By combining performance‐driven heater design with multimaterial fabrication, the system supports thermally triggered shape change, stiffness tuning, and thermochromic visual response, as demonstrated through ...
Naresh Kumar Thanigaivel, Thileepan Stalin, Elgar Kanhere, Aby Raj Plamootil Mathai, Konstantin Sakharov, Yong Lin, Hirusha Madhuwantha Loku Hettige, Gumawang Hiramandala, Shlomo Magdassi, Pablo Valdivia Y Alvarado   +9 more
wiley   +1 more source

New Directions for Natural Killer T Cells in the Immunotherapy of Cancer

Frontiers in Immunology, 2017
Natural killer T (NKT) cells have been placed at the interface between innate and adaptive immunity by a long series of experiments that convincingly showed that beyond cytokine secretion and NK cell recruitment, NKT cells were coordinating dendritic ...
Luc Teyton
doaj   +1 more source

Expression of NKT cells in peripheral blood.

, 2013
(A) Representative flow cytometric analyses on PBMC, lymphocytes, CD3+ T cells and Vα24+Vβ11+ for NKT cells. (B) Fluorescence minus one (FMO) was used for gate strategy for CXCR6, CCR5 and CD69 in NKT cells. (C) Representative flow cytometric analyses on
Beatriz T. Costa-Carvalho (361830), Jennifer E. Snyder-Cappione (360113), Douglas F. Nixon (68367), Karina I. Carvalho (244966), Karina M. Melo (361826), Fernanda R. Bruno (280354), Esper G. Kallas (36139)   +6 more
core   +1 more source

Cumulative Reproductive‐Lactation Burdens Induce a Systemic Immunometabolic Trade‐Off Between Milk Yield and Mammary Health of Dairy Cows

Animal Research and One Health, EarlyView.
A population‐scale longitudinal transcriptomic atlas reveals how lactation stage and parity reshape systemic gene regulation in dairy cows. Multiomics‐inspired analyses uncover dynamic immune and metabolic adaptations that contribute to reproductive longevity and sustained productivity across the bovine lifespan.
Yangyang Shen, Zhenjiang An, Yingying Jiang, Zijian Huang, Kunlin Chen, Yundong Gao, Jianbin Li, Shuwen Xia, Huili Wang   +8 more
wiley   +1 more source