Results 81 to 90 of about 4,443,105 (228)

NKT Cells in Sepsis [PDF]

, 2010
Sepsis is currently a leading cause of death in hospital intensive care units. Previous studies suggest that the pathophysiology of sepsis involves the hyperactivation of complex proinflammatory cascades that include the activation of various immune ...
Briana Leung, Harris, Hobart W, Hobart W. Harris, Leung, Briana   +3 more
core   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Comparison of Circulating NKT Cells Numbers in Multi Drug Resistant Tuberculosis Patients and Healthy Subjects Using Tuberculin Skin Test

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2009
Introduction: Natural killer T (NKT) cells are a subset of lymphocytes that express some NK cells properties. NKT cells have a regulatory role in immune responses. Little is known about the potential role of NKT cells in human infectious diseases.
A Zavaran-Hoseeni, A Shams, MR Masjedi, SH Shah-GasemPoor, M Ryani, N Esfandiari, M Poor-Amiri   +6 more
doaj  

Tissue-Specific Roles of NKT Cells in Tumor Immunity

Frontiers in Immunology, 2018
NKT cells are an unusual population of T cells recognizing lipids presented by CD1d, a non-classical class-I-like molecule, rather than peptides presented by conventional MHC molecules. Type I NKT cells use a semi-invariant T cell receptor and almost all
Masaki Terabe, Jay A. Berzofsky
doaj   +1 more source

Identification of novel self lipids, GlcCer and GalCer, as CD1d-restricted ligands for type II NKT cells

, 2011
NKT cells make up a potent immunomodulating subset of T lymphocytes that recognizes self-lipids presented by CD1d molecules. So far, the identity of most self-lipids presented by CD1d underlying the autoreactivity of NKT cells are unknown. In this study,
Löfbom, Linda,, Teneberg, Susann,, Cardell, Susanna,, Rhost, Sara,, Blomqvist, Maria K.,, Månsson, Jan-Eric,   +5 more
core  

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

Deficiency and dysfunctional roles of natural killer T cells in patients with ARDS

Frontiers in Immunology
ObjectiveAcute respiratory distress syndrome (ARDS) presents a global health challenge, characterized by significant morbidity and mortality. However, the role of natural killer T (NKT) cells in human ARDS remains poorly understood. Therefore, this study
Ki-Jeong Park, Tae-Ok Kim, Young-Nan Cho, Hye-Mi Jin, Young-Goun Jo, Hong-Joon Shin, Bo Gun Kho, Seung-Jung Kee, Yong-Wook Park   +8 more
doaj   +1 more source

Increased Numbers of NK Cells, NKT-Like Cells, and NK Inhibitory Receptors in Peripheral Blood of Patients with Chronic Obstructive Pulmonary Disease

Clinical and Developmental Immunology, 2013
T cells and B cells participate in the pathogenesis of COPD. Currently, NK cells and NKT cells have gained increasing attention. In the present study, 19 COPD patients and 12 healthy nonsmokers (HNS) were recruited, and their pulmonary function was ...
Ying Tang, Xiaodan Li, Man Wang, Qi Zou, Shasha Zhao, Bowen Sun, Lijun Xu, Yanfang Jiang   +7 more
doaj   +1 more source

Expression of NKT cells in peripheral blood.

, 2013
(A) Representative flow cytometric analyses on PBMC, lymphocytes, CD3+ T cells and Vα24+Vβ11+ for NKT cells. (B) Fluorescence minus one (FMO) was used for gate strategy for CXCR6, CCR5 and CD69 in NKT cells. (C) Representative flow cytometric analyses on
Beatriz T. Costa-Carvalho (361830), Jennifer E. Snyder-Cappione (360113), Douglas F. Nixon (68367), Karina I. Carvalho (244966), Karina M. Melo (361826), Fernanda R. Bruno (280354), Esper G. Kallas (36139)   +6 more
core   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source