Results 71 to 80 of about 5,685,226 (248)

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

NKT Cells as Adjuncts to Tumor Immunity

, 2020
Slide 5-40https://digitalcommons.rockefeller.edu/nkt-cells/1038/thumbnail ...
Laboratory, Steinman
core   +1 more source

Regulation of NKT cell localization in homeostasis and infection

Frontiers in Immunology, 2015
Natural killer T (NKT) cells are a specialized subset of T lymphocytes that regulate immune responses in the context of autoimmunity, cancer, and microbial infection.
Drew eSlauenwhite, Brent eJohnston, Brent eJohnston, Brent eJohnston   +3 more
doaj   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Subsets of NKT cells from CVID patients.

, 2013
(A) Percentage of CD4 marker in NKT cells (left) (p = 0.0055). (B) Absolute number of CD4 marker in NKT cells (middle). (C) Representative flow cytometry dot plot of CD4 marker (right). (D) Percentage of CD8 marker in NKT cells (left) (p = 0.011).
Beatriz T. Costa-Carvalho (361830), Jennifer E. Snyder-Cappione (360113), Douglas F. Nixon (68367), Karina I. Carvalho (244966), Karina M. Melo (361826), Fernanda R. Bruno (280354), Esper G. Kallas (36139)   +6 more
core   +1 more source

Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. [PDF]

, 2005
We examined the in vivo behavior of liver natural killer T cells (NKT cells) by intravital fluorescence microscopic imaging of mice in which a green fluorescent protein cDNA was used to replace the gene encoding the chemokine receptor CXCR6.
Stephane Sidobre (77), Dustin Michael L, Michael L Dustin, Thomas O Cameron, Frederic Geissmann (75), Michael J Briskin (71358), Cameron Thomas O, Michael J Briskin, Natasha Manlongat (78), Dan R Littman (1200), Dan R Littman, Kronenberg Mitchell, Manlongat Natasha, Michael L Dustin (71359), Stephane Sidobre, Briskin Michael J, Geissmann Frederic, Sidobre Stephane, Thomas O Cameron (71357), Mitchell Kronenberg, Littman Dan R, Frederic Geissmann, Mitchell Kronenberg (79), Natasha Manlongat   +23 more
core   +2 more sources

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

Inflammatory Phenotype of Intrahepatic Sulfatide-Reactive Type II NKT Cells in Humans With Autoimmune Hepatitis

Frontiers in Immunology, 2019
Background: Natural Killer T (NKT) cells are CD1d-restricted innate-like T cells that can rapidly release stored cytokines upon recognition of lipid antigens. In mice, type I NKT cells seem to promote liver inflammation, whereas type II NKT cells seem to
Marcial Sebode, Marcial Sebode, Jennifer Wigger, Pamela Filpe, Lutz Fischer, Sören Weidemann, Till Krech, Christina Weiler-Normann, Christina Weiler-Normann, Christina Weiler-Normann, Moritz Peiseler, Moritz Peiseler, Johannes Hartl, Johannes Hartl, Eva Tolosa, Johannes Herkel, Christoph Schramm, Christoph Schramm, Christoph Schramm, Ansgar W. Lohse, Ansgar W. Lohse, Philomena Arrenberg   +21 more
doaj   +1 more source

The making of NKT cells [PDF]

Nature Immunology, 2008
Natural killer T cells acquire their unique phenotype and characteristics during development in the thymus. Evidence suggests that the transcription factor PLZF has a unique function in the development of these cells and their acquisition of ‘innate-like’ characteristics.
openaire   +1 more source