Results 91 to 100 of about 5,685,226 (248)

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Highlighting Nuclear DNA in Live Cells With an Activatable BODIPY–Hoechst Conjugate

Chemistry – A European Journal, EarlyView.
Supramolecular association of a Hoechst ligand to double‐stranded DNA activates the fluorescence of a connected BODIPY fluorophore. The resulting fluorescence enhancement enables the imaging of the cellular nucleus with negligible background emission from the extranuclear space in live cells under excitation in the green portion electromagnetic ...
Amit Kumar Singh, William M. Piedra, Andrea Tomassini, Ambarish Kumar Singh, Diana Velluto, Françisco M. Raymo   +5 more
wiley   +1 more source

Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus [PDF]

, 2017
Interferon (IFN) inhibits hepatitis C virus (HCV) replication through up-regulation of intrahepatic IFN-stimulated gene expression but also through activation of host immune cells.
Hiroshi Aikata (128663), Chise Tateno (395774), C. Nelson Hayes, Hidenori Ochi, Masahiro Serikawa (3809083), Hiromi Abe-Chayama, Nobuhiko Hiraga, Takuro Uchida (756174), Miyaki, Eisuke, Hiroshi Aikata, C. Nelson Hayes (128614), Eisuke Miyaki (3809086), Grace Naswa Makokha (3809092), Hideki Ohdan, Hideki Ohdan (300684), Kazuaki Chayama (128675), Hiromi Abe-Chayama (3809089), Masahiro Serikawa, Chise Tateno, Takuro Uchida, Hiromi Kan (756175), Eisuke Miyaki, Nobuhiko Hiraga (128653), Masataka Tsuge (128622), Yuji Ishida (498255), Hidenori Ochi (128649), Masataka Tsuge, Michio Imamura, Michio Imamura (128656), Kazuaki Chayama, Yuji Ishida, Hiromi Kan, Grace Naswa Makokha, Imamura Michio, Ochi Hidenori, Hiraga Nobuhiko, Tsuge Masataka, Miyaki Eisuke, Uchida Takuro, Abe-Chayama Hiromi, Ishida Yuji, Chayama Kazuaki, Hayes C. Nelson, Serikawa Masahiro, Tateno Chise, Makokha Grace Naswa, Ohdan Hideki, Kan Hiromi, Aikata Hiroshi   +48 more
core   +1 more source

Case Study of a Cross‐Platform Evaluation of an Optimized Multicolor Flow Cytometry Immunophenotyping Assay for Human Peripheral Whole Blood

Cytometry Part A, EarlyView.
ABSTRACT Flow cytometry is a commonly used single‐cell analysis technique that can be applied for the immunophenotyping of human blood samples. Nowadays, increasing numbers of clinical trials include translational research programs utilizing flow‐based immune monitoring assays to assess patients' longitudinal immune status.
Lia Mogge, Udo Gaipl, Stefanie Corradini, Benjamin Frey, Anna‐Jasmina Donaubauer   +4 more
wiley   +1 more source

DX5+ NKT cells induce the death of colitis-associated cells: involvement of programmed death ligand-1

, 2006
NKT cells are activated by CD1d and show an immune regulating function. Here, we investigated whether DX5(+)NKT cells could be used to reduce colitis in a chronic colitis mouse model and studied the potential immunological mechanisms involved.
Schlitt, Hans J., Farkas, Stefan A., Geissler, Edward K., Edward K. Geissler, Stefan A. Farkas, Hans J. Schlitt, Matthias Hornung, Hornung, Matthias, Christine Sattler, Sattler, Christine   +9 more
core   +1 more source

Extended routine lymphocyte immunophenotyping refines individual immune organization across a heterogeneous patient cohort

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Routine TBNK immunophenotyping detects the major lymphocyte compartments but may underestimate the biologically relevant variation contributed by less frequent but well‐defined minor lymphocyte subsets. This study evaluated whether extending routine TBNK immunophenotyping with minor lymphocyte subsets provides complementary, analytically ...
Carlos Agustin Villegas Valverde, Yendry Ventura Carmenate, Vianed Marsan Suarez, Yandy Marx Castillo Aleman, Imilla Casado Hernandez, Rachely Hernandez Corrales   +5 more
wiley   +1 more source

IL-21 Modulates Activation of NKT Cells in Patients with Stage IV Malignant Melanoma [PDF]

, 2013
Interleukin-21 (IL-21) is a common γ-chain cytokine produced by T helper and natural killer T (NKT) cells. It has been shown to regulate the response of various lymphocyte subsets including NK, NKT, T and B cells.
Godfrey, DI, Coquet, JM, Skak, K, Davis, ID, Smyth, MJ   +4 more
core   +1 more source

Phenotypic and functional analyses of NK and NKT-like populations during the early stages of chikungunya infection

Frontiers in Microbiology, 2015
The aim of this study was to characterize NK (CD56+CD3−) and NKT-like cell (CD56+CD3+) responses early after chikungunya infection. Expression profiling and functional analysis of T/NK/NKT-like cells were performed on samples from 56 acute and 31 ...
Subrat eThanapati, Rumki eDas, Anuradha S Tripathy   +2 more
doaj   +1 more source

Maze Puzzle Pattern‐Based Static Reconfiguration of Photovoltaic Arrays for Enhanced Shade Dispersion and Power Generation Under Partial Shading Conditions

Energy Science &Engineering, EarlyView.
A new maze puzzle pattern array (PPA) is presented to optimize shade allocation, alleviate the mismatch losses of PV (photovoltaic) arrays in partially shaded circumstances, and maximize output in partially shaded operation with zero extra sensors, switching components, and optimum searching schemes.
Alok Kumar Shrivastav, Anurag Kar, Milan Sasmal, Pankaj Kumar, Soham Dutta   +4 more
wiley   +1 more source