Results 91 to 100 of about 35,995 (263)

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

OMIP‐121: Immune Phenotyping of Canine Peripheral Leukocytes by Mass Cytometry

Cytometry Part A, EarlyView.
ABSTRACT Dogs are a critical non‐rodent species used in preclinical safety studies, particularly, in the pharmaceutical field, due to their physiological, metabolic, and immunological similarities to humans. As such, immunophenotyping of canine peripheral blood mononuclear cells (PBMCs) plays a crucial role in translational research, immune monitoring,
Huyen Thuc Tran Luong, Dominique Revets, Sofie Vercammen, Ario de Marco, Hilde de Rooster, Antonio Cosma   +5 more
wiley   +1 more source

Effect of Interleukin-15 on CD11b, CD54, and CD62L Expression on Natural Killer Cell and Natural Killer T-Like Cells in Systemic Lupus Erythematosus

Mediators of Inflammation, 2016
Adhesion molecules may play an important role in systemic lupus erythematosus (SLE) pathogenesis. We investigated the effect of interleukin- (IL-) 15 on CD11b, CD54, and CD62L expression on natural killer (NK) cells, T cells, and CD56+CD3+ NKT-like cells
Syh-Jae Lin, Ji-Yih Chen, Ming-Ling Kuo, Hsiu-Shan Hsiao, Pei-Tzu Lee, Jing-Long Huang   +5 more
doaj   +1 more source

Development of a deep learning-based 1D convolutional neural network model for cross-species natural killer T cell identification using peripheral blood mononuclear cell single-cell RNA sequencing data [PDF]

Veterinary World
Background and Aim: Natural killer T (NKT) cells exhibit the traits of both T and NK cells. Although their roles have been well studied in humans and mice, limited knowledge is available regarding their roles in dogs and pigs, which serve as models for ...
Kaj Chokeshaiusaha, Thanida Sananmuang, Denis Puthier, Roongtham Kedkovid   +3 more
doaj   +1 more source

Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis

Exploration, EarlyView.
Smart nanodelivery systems deliver therapeutic payloads across the cartilage matrix to ensure their sustained accumulation within chondrocytes at sites of injury. By targeting specific molecular targets and signaling pathways, these platforms modulate the pathological synovium‐cartilage axis to restore immunometabolic homeostasis and drive tissue ...
Qirui Zhao, Zhewen Mi, Shuya Liu, Shijun Liang, Linjia Peng, Zixuan Gao, Jiaming Li, Xiaoqing Lu, Zhiguang Ren, Yongjie Wan, Shengsheng Cui, Longlong Lu, Xiaoyang Gao, Tao Wang, Hui Liang, Furong Tian, de la Fuente Jesus M, Chong Xiang, Luyi Sun, Lichen Xiang, Daxiang Cui   +20 more
wiley   +1 more source

Identification of novel self lipids, GlcCer and GalCer, as CD1d-restricted ligands for type II NKT cells

, 2011
NKT cells make up a potent immunomodulating subset of T lymphocytes that recognizes self-lipids presented by CD1d molecules. So far, the identity of most self-lipids presented by CD1d underlying the autoreactivity of NKT cells are unknown. In this study,
Löfbom, Linda,, Teneberg, Susann,, Cardell, Susanna,, Rhost, Sara,, Blomqvist, Maria K.,, Månsson, Jan-Eric,   +5 more
core  

Increased Numbers of NK Cells, NKT-Like Cells, and NK Inhibitory Receptors in Peripheral Blood of Patients with Chronic Obstructive Pulmonary Disease

Clinical and Developmental Immunology, 2013
T cells and B cells participate in the pathogenesis of COPD. Currently, NK cells and NKT cells have gained increasing attention. In the present study, 19 COPD patients and 12 healthy nonsmokers (HNS) were recruited, and their pulmonary function was ...
Ying Tang, Xiaodan Li, Man Wang, Qi Zou, Shasha Zhao, Bowen Sun, Lijun Xu, Yanfang Jiang   +7 more
doaj   +1 more source

Regulation of dendritic cell subsets by NKT cells

Comptes Rendus. Biologies, 2003
NKT cells expressing both invariant TCRs and NK cell receptors are an important regulatory cell subset active during initiation of innate immune responses. They are involved in a wide variety of immune responses, but the molecular details of their regulatory action are unknown. Transcriptional profiling has been used for analysis of NKT cell activation
Jack L, Strominger, Michael C, Byrne, S Brian, Wilson   +2 more
openaire   +2 more sources

Deficiency and dysfunctional roles of natural killer T cells in patients with ARDS

Frontiers in Immunology
ObjectiveAcute respiratory distress syndrome (ARDS) presents a global health challenge, characterized by significant morbidity and mortality. However, the role of natural killer T (NKT) cells in human ARDS remains poorly understood. Therefore, this study
Ki-Jeong Park, Tae-Ok Kim, Young-Nan Cho, Hye-Mi Jin, Young-Goun Jo, Hong-Joon Shin, Bo Gun Kho, Seung-Jung Kee, Yong-Wook Park   +8 more
doaj   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source