Results 111 to 120 of about 58,157 (254)

Deficiency and dysfunctional roles of natural killer T cells in patients with ARDS

Frontiers in Immunology
ObjectiveAcute respiratory distress syndrome (ARDS) presents a global health challenge, characterized by significant morbidity and mortality. However, the role of natural killer T (NKT) cells in human ARDS remains poorly understood. Therefore, this study
Ki-Jeong Park, Tae-Ok Kim, Young-Nan Cho, Hye-Mi Jin, Young-Goun Jo, Hong-Joon Shin, Bo Gun Kho, Seung-Jung Kee, Yong-Wook Park   +8 more
doaj   +1 more source

NKT Cells Fight Cancer [PDF]

Science, 2010
Biomedicine One way tumors evade the immune system is by fostering an immunosuppressive environment. Although immune cells such as macrophages are known to contribute to this immunosuppression, whether neutrophils, an immune cell typically associated with inflammation, do too has not been fully explored. De Santo et al.
openaire   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

Randomized phase 2 trial of regadenoson for treatment of acute vaso-occlusive crises in sickle cell disease [PDF]

, 2017
Key Points Regadenoson did not reduce iNKT cell activation to a prespecified level when administered to patients with SCD. Because iNKT cell activation was not reduced, the benefit of iNKT cell-based therapies in SCD cannot be determined.
Achebe, Maureen, Chu, Hillary, Field, Joshua J., George, Alex, Gordeuk, Victor R., Gowhari, Michel, Heeney, Matthew M., Hoppe, Carolyn, Lin, Gene, Linden, Joel, Majerus, Elaine, Nathan, David G., Neuberg, Donna, Puligandla, Maneka, Sheehan, Brian   +14 more
core   +2 more sources

Deterministic Fiber‐Optic Spectral Engineering Enables Three‐Color Multiplexed Two‐Photon Microscopy

Laser &Photonics Reviews, EarlyView.
A simulation‐guided spectral‐engineering framework maps the nonlinear parameter space of a fiber laser platform to identify balanced three‐band excitation states. The resulting 960, 1080, and 1175 nm femtosecond pulses deliver nJ‐level energies for low‐cross‐talk chromatically multiplexed two‐photon microscopy.
Marvin Edelmann, Andreu Matamoros‐Angles, Mohsin Shafiq, Mikhail Pergament, Franz X. Kärtner, Markus Glatzel   +5 more
wiley   +1 more source

Comparison of Circulating NKT Cells Numbers in Multi Drug Resistant Tuberculosis Patients and Healthy Subjects Using Tuberculin Skin Test

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2009
Introduction: Natural killer T (NKT) cells are a subset of lymphocytes that express some NK cells properties. NKT cells have a regulatory role in immune responses. Little is known about the potential role of NKT cells in human infectious diseases.
A Zavaran-Hoseeni, A Shams, MR Masjedi, SH Shah-GasemPoor, M Ryani, N Esfandiari, M Poor-Amiri   +6 more
doaj  

Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants. [PDF]

, 2020
The Genotype-Tissue Expression (GTEx) resource has provided insights into the regulatory impact of genetic variation on gene expression across human tissues; however, thus far has not considered how variation acts at the resolution of the different cell ...
D'Antonio, Matteo, D'Antonio-Chronowska, Agnieszka, Donovan, Margaret KR, Frazer, Kelly A   +3 more
core  

MendelR: A One‐Stop R Toolkit for Mendelian Randomization Analysis

Med Research, EarlyView.
ABSTRACT MendelR is a fully automated R package specifically developed for Mendelian randomization (MR) studies, designed to address the technical challenges of causal inference in biomedical research. As a powerful causal inference method, Mendelian randomization can effectively reduce confounding bias in observational studies.
Xiaohong Ke, Kailai Li, Anqi Lin, Yasi Zhang, Peng Luo   +4 more
wiley   +1 more source

Tissue-Specific Roles of NKT Cells in Tumor Immunity

Frontiers in Immunology, 2018
NKT cells are an unusual population of T cells recognizing lipids presented by CD1d, a non-classical class-I-like molecule, rather than peptides presented by conventional MHC molecules. Type I NKT cells use a semi-invariant T cell receptor and almost all
Masaki Terabe, Jay A. Berzofsky
doaj   +1 more source