Results 111 to 120 of about 35,995 (263)

Neurofibromin 1 Impairs Natural Killer T-Cell-Dependent Antitumor Immunity against a T-Cell Lymphoma

Frontiers in Immunology, 2018
Neurofibromin 1 (NF1) is a tumor suppressor gene encoding a Ras GTPase that negatively regulates Ras signaling pathways. Mutations in NF1 are linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome.
Jianyun Liu, Richard M. Gallo, Masood A. Khan, Masood A. Khan, Gourapura J. Renukaradhya, Gourapura J. Renukaradhya, Randy R. Brutkiewicz   +6 more
doaj   +1 more source

NKT cells direct monocytes into a DC differentiation pathway

, 2007
Monocytes can differentiate into macrophages or dendritic cells (DCs). The processes that promote their differentiation along one pathway rather than the other remain unknown. NKT cells are regulatory T cells that respond functionally to self and foreign
Gumperz, JE, Keaton, JM, Besra, Gurdyal; id_orcid, Hegde, S, Reddington, Faye, Chen, X   +5 more
core   +1 more source

Voice of Asia: Provision of Patient‐Centered Care in Oral Cavity Cancer: A Qualitative Study With Patients, Caregivers, and Healthcare Professionals in Five Asia‐Pacific Regions

Asia-Pacific Journal of Clinical Oncology, EarlyView.
The study identified key barriers to optimal patient‐centered care, including delayed diagnosis due to awareness and stigma‐related barriers among patients and caregivers, and opportunities to enhance multidisciplinary coordination. Resource limitations impacted nursing and psychosocial support, while access to support care varied across regions.
Edwin Pun Hui, Puma Sundaresan, Hye Ryun Kim, Khoi Tuan Nguyen, Tracey E Nicholls, Hai‐Ling Teng, Yu‐Chung Li, Ying Jie Yew, Regina Gowindah, Con Stylianou, Pei‐Jen Lou   +10 more
wiley   +1 more source

Harnessing NKT cells for therapeutic applications.

, 2007
Activation of NKT cells leads to the maturation of dendritic cells and efficiently assists priming of antigen-specific immune responses. The lack of polymorphism of CDld molecules and the evolutionary conservation of NKT cell responses highlight the ...
Salio, M, Cerundolo, Vincenzo
core   +1 more source

Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells

Allergy, EarlyView.
We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller, Julia Hambach, Alessa Zoe Schaffrath, Thomas Eden, Sophia Cichutek, Anna Josephine Gebhardt, Natalie Tode, Ronald Maitschke‐Rajasekharan, Philipp Lewe, Sharon Qi, Susanne Witt, Marie Eggers, Nicola M. Tomas, Friedrich Haag, Friedrich Koch‐Nolte, Boris Fehse, Kristoffer Riecken   +16 more
wiley   +1 more source

The Testicular Cancer Consortium (TECAC): Filling Knowledge Gaps in the Genetic Etiology of Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The Testicular Cancer Consortium (TECAC) was established in 2012 and is comprised of researchers from over 25 centers in Europe and North America. TECAC's overarching goal is to investigate the genetic susceptibility of testicular germ cell tumors (TGCT) to better understand their biology, impact prevention strategies, and inform ...
Peter A. Kanetsky, Kristian Almstrup, Svetlana Cherlin, Victoria K. Cortessis, Alberto Ferlin, Jourik A. Gietema, Anna González‐Neira, Tom Grotmol, Robert J. Hamilton, Trine B. Haugen, Lambertus A. Kiemeney, Jung Kim, Csilla Krausz, Davor Lessel, Ragnhild A. Lothe, Kevin T. Nead, Jérémie Nsengimana, Jenny N. Poynter, Ewa Rajpert‐DeMeyts, Lorenzo Richiardi, Stephen M. Schwartz, Rolf I. Skotheim, Douglas R. Stewart, Clare Turnbull, Fredrik Wiklund, Tongzhang Zheng, Katherine L. Nathanson, Katherine A. McGlynn, for the Testicular Cancer Consortium   +28 more
wiley   +1 more source

The Effect of Specific Immunotherapy on Natural Killer T cells in Peripheral Blood of House Dust Mite-Sensitized Children with Asthma

Clinical and Developmental Immunology, 2012
To investigate the effects of specific immunotherapy on the NKT cells in peripheral blood and the ability of NKT cells to proliferate in response to alpha-galactosylceramide (alpha-GalCer) in house-dust-mite- (HDM-) sensitized asthma children, peripheral
Lu Yan-ming, Cao Lan-fang, Li Chen, Li Ya-qin, Chen Wei, Zhang Wen-ming   +5 more
doaj   +1 more source

Synovial fluid NKT cells display different properties compared to peripheral blood NKT cells in rheumatoid arthritis

, 2005
Natural killer T cells (NKT) are a population of regulatory T cells that co-express an invariant T cell receptor as well as NK cell markers. Several studies have shown that NKT cells are decreased or dysfunctional in autoimmune conditions such as insulin-
GEUSENS, Piet, SOMERS, Veerle, LINSEN, Loes, THEWISSEN, Marielle, STINISSEN, Piet, RAUS, Jef   +5 more
core  

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Migration and homeostasis of NKT cells

, 2010
TypescriptThesis (PhD) -- University of Melbourne, Faculty of Medicine, Dentistry and Health Sciences, 2010Includes bibliographical references (pages 187-220) and appendices (pages 221-233).NKT cells are a CD ld-restricted T cell lineage with the ability
Pitt, Lauren Alicia.
core