Results 131 to 140 of about 58,157 (254)

A Case for Anti‐IgE Vaccination

Allergy, EarlyView.
ABSTRACT Immunoglobulin E (IgE) plays a central role in allergic diseases by binding to the high‐affinity receptor FcεRI on mast cells and basophils, where allergen‐induced crosslinking triggers potent inflammatory responses. Various mechanisms by which IgE responses are generated and functionally regulated remain elusive despite many years of research.
Paul Engeroff, Zahra Gharailoo, Monique Vogel, Martin F. Bachmann   +3 more
wiley   +1 more source

The Effect of Specific Immunotherapy on Natural Killer T cells in Peripheral Blood of House Dust Mite-Sensitized Children with Asthma

Clinical and Developmental Immunology, 2012
To investigate the effects of specific immunotherapy on the NKT cells in peripheral blood and the ability of NKT cells to proliferate in response to alpha-galactosylceramide (alpha-GalCer) in house-dust-mite- (HDM-) sensitized asthma children, peripheral
Lu Yan-ming, Cao Lan-fang, Li Chen, Li Ya-qin, Chen Wei, Zhang Wen-ming   +5 more
doaj   +1 more source

The Testicular Cancer Consortium (TECAC): Filling Knowledge Gaps in the Genetic Etiology of Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The Testicular Cancer Consortium (TECAC) was established in 2012 and is comprised of researchers from over 25 centers in Europe and North America. TECAC's overarching goal is to investigate the genetic susceptibility of testicular germ cell tumors (TGCT) to better understand their biology, impact prevention strategies, and inform ...
Peter A. Kanetsky, Kristian Almstrup, Svetlana Cherlin, Victoria K. Cortessis, Alberto Ferlin, Jourik A. Gietema, Anna González‐Neira, Tom Grotmol, Robert J. Hamilton, Trine B. Haugen, Lambertus A. Kiemeney, Jung Kim, Csilla Krausz, Davor Lessel, Ragnhild A. Lothe, Kevin T. Nead, Jérémie Nsengimana, Jenny N. Poynter, Ewa Rajpert‐DeMeyts, Lorenzo Richiardi, Stephen M. Schwartz, Rolf I. Skotheim, Douglas R. Stewart, Clare Turnbull, Fredrik Wiklund, Tongzhang Zheng, Katherine L. Nathanson, Katherine A. McGlynn, for the Testicular Cancer Consortium   +28 more
wiley   +1 more source

Bayesian inference for dynamic Q matrices and attribute trajectories in hidden Markov diagnostic classification models

British Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract Hidden Markov diagnostic classification models capture how students' cognitive attributes evolve over time. This paper introduces a Bayesian Markov chain Monte Carlo algorithm for diagnostic classification models that jointly estimates time‐varying Q matrices, latent attributes, item parameters, attribute class proportions and transition ...
Chen‐Wei Liu
wiley   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Ultraviolet cut off and Bosonic Dominance

, 2003
We rederive the thermodynamical properties of a non interacting gas in the presence of a minimal uncertainty in length. Apart from the phase space measure which is modified due to a change of the Heisenberg uncertainty relations, the presence of an ...
A. Kempf, A. Kempf, A. Kempf, A. Kempf, C.S. Chu, F. Brau, H. Hinrichsen, J. Bekenstein, J. Martin, J.C. Niemeyer, J.C. Niemeyer, J.C. Niemeyer, L. Mersini, Lay Nam Chang, M. Lemoine, M. Lubo, M. Pillin, Musongela Lubo, N. A. Ahmed, R. Brandenberger, R. Brout, R. Brout, S. Corley, S. Hawking, S. Hawking, S. Kalyana Rama, S. Shankaranarayanan, S. Shankaranarayanan, T. Jacobson, T. Jacobson, W.G. Unruh, W.G. Unruh   +31 more
core   +1 more source

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

Immunology &Cell Biology, EarlyView.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez, Hui Jing Lim, Brunda Nijagal, Yuting Yang, Nicole Lau, Jeffrey YW Mak, David P Fairlie, Hayley Newton, Mariolina Salio, Jose A Villadangos, Hamish EG McWilliam   +10 more
wiley   +1 more source

An impact of type 2 diabetes mellitus on NKT-like cell population in humans: a new insight into impaired immune response in hyperglycemia

Frontiers in Endocrinology
BackgroundType 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by insulin resistance and pancreatic β-cell dysfunction. T2DM is associated with increased risk of infections and of several malignancies, although the underlying ...
Emilia Adamska-Fita, Przemysław Wiktor Śliwka, Przemysław Wiktor Śliwka, Bartłomiej Stasiak, Małgorzata Karbownik-Lewińska, Małgorzata Karbownik-Lewińska, Andrzej Lewiński, Andrzej Lewiński, Magdalena Stasiak   +8 more
doaj   +1 more source

Hyperspectral tomographic diffractive microscopy: Development and applications

Journal of Microscopy, EarlyView.
Abstract Tomographic Diffractive Microscopy (TDM) provides label‐free three‐dimensional imaging of transparent samples with resolution surpassing confocal limits. At IRIMAS, successive instrumental developments since 2009 have enhanced TDM capabilities through transmission, reflection, isotropic, polarisation‐sensitive, and dual‐view configurations ...
Leonardo Pestana Legori, Carlos Alberto Chacón Ávila, Matthieu Debailleul, Nicolas Verrier, Olivier Haeberlé   +4 more
wiley   +1 more source

Learning How to Count: A High Multiplicity Search for the LHC

, 2013
We introduce a search technique that is sensitive to a broad class of signals with large final state multiplicities. Events are clustered into large radius jets and jet substructure techniques are used to count the number of subjets within each jet.
Hedri, Sonia El, Hook, Anson, Jankowiak, Martin, Wacker, Jay G.   +3 more
core   +1 more source