Results 121 to 130 of about 5,685,226 (248)

Bayesian inference for dynamic Q matrices and attribute trajectories in hidden Markov diagnostic classification models

British Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract Hidden Markov diagnostic classification models capture how students' cognitive attributes evolve over time. This paper introduces a Bayesian Markov chain Monte Carlo algorithm for diagnostic classification models that jointly estimates time‐varying Q matrices, latent attributes, item parameters, attribute class proportions and transition ...
Chen‐Wei Liu
wiley   +1 more source

Determinação dos valores de referência das populações linfocitárias em sangue periférico de indivíduos adultos [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2013Os resultados dos testes laboratoriais devem ser comparados o intervalo de referência com o objetivo ...
Oliveira, Renata Cristina Messores Rudolf de
core  

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Effect of Interleukin-15 on CD11b, CD54, and CD62L Expression on Natural Killer Cell and Natural Killer T-Like Cells in Systemic Lupus Erythematosus

Mediators of Inflammation, 2016
Adhesion molecules may play an important role in systemic lupus erythematosus (SLE) pathogenesis. We investigated the effect of interleukin- (IL-) 15 on CD11b, CD54, and CD62L expression on natural killer (NK) cells, T cells, and CD56+CD3+ NKT-like cells
Syh-Jae Lin, Ji-Yih Chen, Ming-Ling Kuo, Hsiu-Shan Hsiao, Pei-Tzu Lee, Jing-Long Huang   +5 more
doaj   +1 more source

High AXL Expression and Stromal–Angiogenic Immune Phenotypes in Upper Gastrointestinal Cancers

Cancer Science, EarlyView.
In 337 patients with advanced gastric or esophageal cancer from SCRUM‐Japan MONSTAR‐SCREEN‐2, high AXL expression was independently associated with shorter overall survival and marked a stromal‐angiogenic tumor microenvironment with MET and VEGFR‐family co‐upregulation, but was not associated with progression‐free survival on immune checkpoint blockade.
Kyosuke Seguchi, Tadayoshi Hashimoto, Takao Fujisawa, Akitaka Makiyama, Toshihiro Kudo, Kentaro Yamazaki, Koushiro Ohtsubo, Taroh Satoh, Chigusa Morizane, Shogen Boku, Eiji Oki, Naoki Takahashi, Fumio Nagashima, Shigenori Kadowaki, Takeshi Kato, Yoshito Komatsu, Yohei Kubota, Akihito Tsuji, Yukiko Fukuda, Naoko Iida, Taro Shibuki, Hideaki Bando, Karam Ashouri, Sandra Algaze, Heinz‐Josef Lenz, Takayuki Yoshino   +25 more
wiley   +1 more source

Chemotherapy pretreatment sensitizes solid tumor-derived cell lines to Vα24+ NKT cell-mediated cytotoxicity

, 2006
There is an increasing awareness of the therapeutic potential for combining immune-based therapies with chemotherapy in the treatment of malignant diseases, but few published studies evaluate possible cytotoxic synergies between chemotherapy and ...
Nieda, Mie, Tony Kenna, Andrew J. Nicol, Nicol, Andrew J., Stephen R. Mattarollo, Mie Nieda, Kenna, Tony, Mattarollo, Stephen R.   +7 more
core   +1 more source

Lactate and Lactylation: What We Know and What We Expect in Tumour Progression

Cell Proliferation, EarlyView.
Lactate and lactylation in cancer cells have been shown to accelerate tumour development in various ways, including stemness generation, metabolic dysregulation, cell death, chemotherapy resistance, and cell cycle disorder. In addition, lactate and lactylation promote angiogenesis and create an immunosuppressive microenvironment, which promotes tumour ...
Qi Zhang, Zhenzhen Han, Youjia Duan
wiley   +1 more source

Structures of the UBR4 complex reveal a giant arena to capture diverse substrates for ubiquitin chain elongation

The FEBS Journal, EarlyView.
This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley   +1 more source

Critical Role of NKT Cells in Posttransplant Alloantibody Production

, 2014
We previously reported that posttransplant alloantibody production in CD8-deficient hosts is IL-4+ CD4+ T cell-dependent and IgG1 isotype-dominant. The current studies investigated the hypothesis that IL-4-producing natural killer T cells (NKT cells ...
J. M. Zimmerer, Abdel-Rasoul, M., Bumgardner, G. L., P. Swamy, M. Abdel-Rasoul, Sanghavi, P. B., S. M. Elzein, G. L. Bumgardner, Swamy, P., C. L. Wright, P. B. Sanghavi, Zimmerer, J. M., Brutkiewicz, R. R., Wright, C. L., Elzein, S. M., R. R. Brutkiewicz   +15 more
core   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source