Results 141 to 150 of about 5,685,226 (248)

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, Volume 15, Issue 41, 6 November 2026.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Altered phenotypic and functional characteristics of CD3(+)CD56(+) NKT-like cells in human gastric cancer

, 2016
CD3+CD56+ natural killer T (NKT)-like cells are a group of CD3+ T cells sharing characteristics of NK and T cells and constitute a major component of host antitumor immune response in human cancer.
P Cheng (9892673), Y Zhuang (4703695), P Luo (13488355), Q-M Zou (14853952), L-S Peng (14853928), Y-L Zhao (14853934), G Guo (7409615), Y-P Lv (14853946), T-T Wang (14853937), F-Y Mao (14853931), Weisan Chen (9487766), Y-S Teng (14853949), J-Y Zhang (14853940), N Chen (9858485), W-H Li (14853943)   +14 more
core   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, Volume 13, Issue 62, 9 November 2026.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Graphene‐Engineered Rear Interfaces Enable Efficient Flexible CZTSSe Solar Cells on Metal Foils

Advanced Science, Volume 13, Issue 62, 9 November 2026.
An atomically thin graphene interlayer stabilizes the rear interface of flexible CZTSSe solar cells by regulating interfacial stress, suppressing detrimental interfacial reactions, and reducing the back‐contact barrier. This strategy simultaneously improves photovoltaic performance and mechanical durability.
Yixiong Ji, Wentong Yang, Di Yan, Wei Luo, Jialu Li, Shi Tang, Jintao Fu, James Bullock, Mei Gao, Xin Li, Zhancheng Li, Jun Yang, Zhenghong Xiong, Yang Peng, Pengjun Zhao, Xingzhan Wei, Haofei Shi, Paul Mulvaney, Fangyang Liu   +18 more
wiley   +1 more source

Advances in Multidimensional Molecular Mechanisms of Epilepsy and Precision Therapy Strategies

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Epilepsy arises from a multidimensional network imbalance, integrating genetic, inflammatory, and metabolic disruptions. This complexity drives neuronal hyperexcitability and underpins therapeutic challenges. Our review highlights how emerging precision strategies, from targeted molecular therapies to neuromodulation, offer a transformative path toward
Yimin Han, Jingxuan Xu, Yuntian Shen, Jitai Zhang, Xia Li, Xinlei Yao, Lei Qi, Hualin Sun   +7 more
wiley   +1 more source

Targeted Protein Degradation: From Molecular Mechanisms to Emerging Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Graphical overview of targeted protein degradation: mechanisms, molecular determinants, delivery strategies, and therapeutic development. This graphical abstract summarizes the major degradation pathways involved in targeted protein degradation, including the ubiquitin–proteasome system, endocytosis–lysosome pathway, and autophagy‐dependent degradation.
Huaijuan Guo, Haishuang Duan, Yang Liu, Kelan Fang, Lujia Xiao, Ling Bai, Xiao Qu, Xuebing Yan, Kun Zhang   +8 more
wiley   +1 more source

A Pan‐Hepatic T‐Cell Atlas Identifies Disease‐Specific Immune Dysfunction and Therapeutic Targets for Immunotherapy

MedComm, Volume 7, Issue 11, November 2026.
A Pan‐HEpatic single‐cell Atlas of T cells (Pheat) was constructed covering chronic hepatitis, cirrhosis, hepatocellular carcinoma (HCC), and healthy controls. CD8+ exhausted T cells (Tex) and CD4+ regulatory T cells (Treg) were delineated profound through decoding molecular and cellular variance, immune checkpoint networks, pathway analysis, and drug ...
Si‐Yuan Chen, You‐Yuan Wang, Shuang‐Nan Zhou, Ming‐Ju Zhou, Xia Li, Wei‐Zhe Li, Meng‐Meng Zhu, Yu‐Xuan Yang, Ying Sun, Peiyao Fan, Jing Li, Xing Fan, Ruonan Xu, Yan‐Mei Jiao, Jin‐Wen Song, Cheng Zhen, Ming Shi, Chao Zhang, Fu‐Sheng Wang   +18 more
wiley   +1 more source

Novel lipid antigens for NKT cells in cancer. [PDF]

Front Immunol, 2023
Lee MS, Webb TJ.
europepmc   +1 more source

Plant‐Derived Extracellular Vesicles: Biogenesis, Function, and Application in Cancer Immunotherapy

Phytotherapy Research, Volume 40, Issue 11, Page 6685-6708, November 2026.
This illustration shows the biogenesis pathways of edible and medicinal plant‐derived extracellular vesicles (PDEVs) and their therapeutic effects following uptake in the human body, highlighting their potential for application in cancer immunotherapy. ABSTRACT Plant‐derived extracellular vesicles (PDEVs) are nanoscale, lipid bilayer‐enclosed vesicles ...
Guosheng Li, Mengyu Li, Shujing Liu, Yuan Wei, Chen Wang   +4 more
wiley   +1 more source

Multiple Sclerosis and Viruses: « Liaisons Dangereuses »

Reviews in Medical Virology, Volume 36, Issue 6, November 2026.
ABSTRACT Multiple sclerosis (MS) is a complex, multifactorial neurodegenerative disease with an aetiology that is still partially elusive. Several risk factors are associated with MS development including genetic predisposition and various environmental stressors; however, recently, viral infections have gained significant attention as a crucial ...
Samanta Plavina, Daniela Malakovska, Jolanta Kalnina, Ilva Trapina, Elina Leonova, Mohammed Habib, Susanne Schifmann, Jegors Paramonovs, Nikolajs Sjakste, Yegor Vassetzky, Emmanuel Drouet, Natalia Paramonova   +11 more
wiley   +1 more source