Results 161 to 170 of about 58,157 (254)

Natural Killer T (NKT) Cells in Autoimmune Hepatitis: Current Evidence from Basic and Clinical Research. [PDF]

Cells, 2023
Poddighe D, Maulenkul T, Zhubanova G, Akhmaldtinova L, Dossybayeva K.   +4 more
europepmc   +1 more source

Spatiotemporal Transcriptomics Characterizes Immune Microenvironment During Mouse Liver Aging

Aging Cell, Volume 25, Issue 5, May 2026.
T cells are the most dynamically altered immune population in the aged liver. Accumulation of CD8+ Tex in aged livers. Spatial enrichment of CD8+ Tex in the portal vein zone. PP hepatocytes promote T cell exhaustion via Lpin1. T cell exhaustion correlates with liver disease progression.
Jiahua Lu, Yuqian Wang, Wenxue Zhao, Zihao Zhao, Zhaoya Gao, Jin Gu, Cheng Li, Jie Cheng   +7 more
wiley   +1 more source

Single‐Cell Analysis Identified a Recurrent Malignant‐Associated Transcriptional State in Colorectal Cancer

Cancer Science, Volume 117, Issue 5, Page 1397-1411, May 2026.
Colorectal cancer (CRC) shows high molecular heterogeneity, yet single‐cell data from Japanese patients are limited. We performed scRNA‐seq on tumors and adjacent normal tissues from four Japanese CRC patients and identified a shared malignant cell cluster with high KCNQ1OT1 expression and reduced RASSF6 levels.
Sadahiro Iwabuchi, Kentaro Sawada, Motohiro Kojima, Miho Ozawa, Hiroya Taniguchi, Hideaki Bando, Kazumi Abe, Yuta Kuze, Kiyomi Imamura, Yukie Kashima, Yoshihiko Hirohashi, Atsushi Tajima, Toshihiko Torigoe, Yutaka Suzuki, Takayuki Yoshino, Shinichi Hashimoto   +15 more
wiley   +1 more source

NKT cells aid antiviral responses [PDF]

Nature Immunology, 2018
openaire   +2 more sources

From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki, Minahil Sharjeel, Jennifer E. Cowan   +2 more
wiley   +1 more source

Mixed Signals: T Cells as Architects of IgE Immunity

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Abigail L. Tierney, Wallace P. Bezerra, Stephanie C. Eisenbarth, Adam Williams   +3 more
wiley   +1 more source

Identification of VEGFB associated with NKT cells in diabetic foot ulcers: Single-cell analysis and machine learning. [PDF]

Medicine (Baltimore)
Wang W, He Y, You T, Lei M, Chen J.
europepmc   +1 more source

Editorial: NKT Cells in Cancer Immunotherapy [PDF]

Frontiers in Immunology, 2020
Tonya J. Webb, Weiming Yuan, Everett Meyer, Paolo Dellabona   +3 more
openaire   +3 more sources

Targeting orthotopic and metastatic pancreatic cancer with allogeneic stem cell-engineered mesothelin-redirected CAR-NKT cells. [PDF]

Proc Natl Acad Sci U S A
Li YR, Shen X, Zhu E, Li Z, Huang J, Le T, Tran C, Radu CG, Yang L.   +8 more
europepmc   +1 more source

Invariant and Diverse NKT Cells Regulate Bacterial Clearance and Pathology in Chlamydial Genital Tract Infection in Mice. [PDF]

Pathogens
Ishii K, Soejima T, Ohnishi Y, Ozuru R, Itoh R, Chou B, Yoshimura M, Shimizu A, Kurihara Y, Sakamoto A, Hiromatsu K.   +10 more
europepmc   +1 more source