Results 31 to 40 of about 4,443,105 (228)

Natural killer T cells from peripheral blood of patients with pregnancy-induced hypertension inhibit the proliferation and migration of vascular endothelial cells by secreting interleukin-17

Biotechnology & Biotechnological Equipment, 2019
The aim of this study was to investigate the phenotype and function of NKT cells and the effect of NKT cells on the functions of vascular endothelial cells. The study included 30 pregnant women with hypertension and 20 pregnant women with normal delivery.
Aixin Zhao, Kun Liu, Yunfang Qi
doaj   +1 more source

NKT Cells [PDF]

, 2003
A defect in RelB, a member of the Rel/nuclear factor (NF)-kappa B family of transcription factors, affects antigen presenting cells and the formation of lymphoid organs, but its role in T lymphocyte differentiation is not well characterized.
Shaikh, Raziya B, Lisa Ma, Hilde Cheroutre, Andrew J. Leishman, Raziya B. Shaikh, Carl F. Ware, Theresa A. Banks, Lo, David, Kirsten J. L. Hammond, Turovskaya, Olga, Theodore I. Prigozy, De Winter, Hilde, Ma, Lisa, Olga Turovskaya, Banks, Theresa A, Kronenberg, Mitchell, Stephane Sidobre, Cheroutre, Hilde, Hilde De Winter, David Lo, Leishman, Andrew J, Mitchell Kronenberg, Dirk Elewaut, Ware, Carl F, Elewaut, Dirk, Prigozy, Theodore I, Hammond, Kirsten JL, Sidobre, Stephane   +27 more
core   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

A comprehensive ex vivo functional analysis of human NKT cells reveals production of MIP1-α and MIP1-β, a lack of IL-17, and a Th1-bias in males. [PDF]

PLoS ONE, 2010
NKT cells contribute to the modulation of immune responses and are believed to be important in the pathogenesis of autoimmune and infectious diseases, as well as cancer.
Jennifer E Snyder-Cappione, Camilla Tincati, Ijeoma G Eccles-James, Amedeo J Cappione, Lishomwa C Ndhlovu, Laura L Koth, Douglas F Nixon   +6 more
doaj   +1 more source

CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides

Frontiers in Immunology, 2018
NKT cells belong to a distinct subset of T cells that recognize hydrophobic antigens presented by major histocompatibility complex class I-like molecules, such as CD1d.
Yusuke Nishioka, Sakiko Masuda, Utano Tomaru, Akihiro Ishizu   +3 more
doaj   +1 more source

Recognition of lyso-phospholipids by human natural killer T lymphocytes.

PLoS Biology, 2009
Natural killer T (NKT) cells are a subset of T lymphocytes with potent immunoregulatory properties. Recognition of self-antigens presented by CD1d molecules is an important route of NKT cell activation; however, the molecular identity of specific ...
Lisa M Fox, Daryl G Cox, Jennifer L Lockridge, Xiaohua Wang, Xiuxu Chen, Louise Scharf, David L Trott, Rachel M Ndonye, Natacha Veerapen, Gurdyal S Besra, Amy R Howell, Mark E Cook, Erin J Adams, William H Hildebrand, Jenny E Gumperz   +14 more
doaj   +1 more source

Efficient isolation of mouse liver NKT cells by perfusion. [PDF]

PLoS ONE, 2010
BACKGROUND: NKT cell is a population of unconventional T cells that mediate both innate and adaptive T cell responses. Since NKT cells are most abundant in the liver, much of NKT biology has been learnt from studies of NKT cells isolated from liver. This
Xianfeng Fang, Peishuang Du, Yang Liu, Jie Tang   +3 more
doaj   +1 more source

NKT Cells Contribute to the Control of Microbial Infections

Frontiers in Cellular and Infection Microbiology, 2021
Innate (-like) T lymphocytes such as natural killer T (NKT) cells play a pivotal role in the recognition of microbial infections and their subsequent elimination.
Stefan Vogt, Jochen Mattner, Jochen Mattner   +2 more
doaj   +1 more source

Altered phenotypic and metabolic characteristics of FOXP3+CD3+CD56+ natural killer T (NKT)-like cells in human malignant pleural effusion

OncoImmunology, 2023
Malignant pleural effusion (MPE) is a functional ‘cold’ tumor microenvironment in which the antitumor activity of CD8+ T cells and natural killer T (NKT)-like cells is suppressed and the function of regulatory T (Treg) cells is enhanced.
Zi-Hao Wang, Pei Zhang, Wen-Bei Peng, Lin-Lin Ye, Xuan Xiang, Xiao-Shan Wei, Yi-Ran Niu, Si-Yu Zhang, Qian-Qian Xue, Hao-Lei Wang, Qiong Zhou   +10 more
doaj   +1 more source

NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells

, 2003
A major group of murine NK T (NKT) cells express an invariant Valpha14Jalpha18 TCR a-chain specific for glycolipid Ags presented by CD1d. Murine Valpha14alpha18(+) account for 30-50% of hepatic T cells and have potent antitumor activities.
Porcelli, SA, Kenna, T, Koezuka, Y, Golden-Mason, Lucy, Steven A. Porcelli, Tony Kenna, Mason, LG, O'Farrelly, C, Porcelli, Steven A., Hegarty, JE, John E. Hegarty, Koezuka, Yasuhiko, Doherty, DG, Cliona O’Farrelly, Derek G. Doherty, O'Farrelly, Cliona, Hegarty, John E., Kenna, Tony, Doherty, Derek G., Yasuhiko Koezuka, Lucy Golden Mason   +20 more
core   +1 more source