Results 31 to 40 of about 58,157 (254)
Natural Killer T Cells in Cancer Immunotherapy
Frontiers in Immunology, 2017 Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid antigens. Following stimulation, NKT cells lead to downstream activation of both innate and adaptive immune cells in the tumor microenvironment.
Shiny Nair, Madhav V. Dhodapkar
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Frontiers in Immunology, 2020 Methicillin-resistant Staphylococcus aureus (SA) bacteremia is responsible for over 10,000 deaths in the hospital setting each year. Both conventional CD4+ T cells and γδ T cells play protective roles in SA infection through secretion of IFN-γ and IL-17.
Samantha Genardi +9 more
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NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNF AIP3/A20 [PDF]
, 2016 Natural killer T (NKT) cells are innate lymphocytes that differentiate into NKT1, NKT2, and NKT17 sublineages during development. However, the signaling events that control NKT sublineage specification and differentiation remain poorly understood.
Bart N. Lambrecht +39 more
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Phenotypic characterization of CD8+NKT cells [PDF]
European Journal of Immunology, 2000 We describe a novel CD8(+)NKT cell population expressing TCRalpha /beta or TCRgamma /delta. These CD8(+)NKT cells were prominent in the liver, and except for the thymus, virtually absent in other lymphoid organs. CD8(+)NKT cells expressed activation markers and comprised a high proportion of Ly49(+) cells.
Emoto, M. +4 more
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Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases
Frontiers in Immunology, 2022 Natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens rather than peptides. Due to their immunoregulatory properties, extensive work has been done to elucidate the immune functions of NKT cells in various immune ...
Sung Won Lee +3 more
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Invariant NKT cells and rheumatic disease: Focus on primary sjogren syndrome [PDF]
, 2019 Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology.
Barbera L. L. +5 more
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Pro-inflammatory activated Kupffer cells by lipids induce hepatic NKT cells deficiency through activation-induced cell death. [PDF]
PLoS ONE, 2013 BACKGROUND: Dietary lipids play an important role in the progression of non-alcoholic fatty liver disease (NAFLD) through alternation of liver innate immune response.
Tongfang Tang +4 more
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A Potent CD1d-binding Glycolipid for iNKT-Cell-based Therapy Against Human Breast Cancer [PDF]
, 2019 Background/Aim: Invariant natural killer T-cells (iNKT) stimulated by CD1d-binding glycolipids have been shown to exert antitumor effects by a number of studies in a mouse model.
Brutkiewicz, Randy R. +3 more
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NKT cells in cardiovascular diseases
European Journal of Pharmacology, 2017 Despite life-style advice and the prescription of cholesterol-lowering and anti-thrombotic drugs, cardiovascular diseases are still the leading cause of death worldwide. Therefore, there is an urgent need for new therapeutic strategies focussing on atherosclerosis, the major underlying pathology of cardiovascular diseases characterized by an ...
Puijvelde, G.H.M. van, Kuiper, J.
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NKT cells: In the beginning… [PDF]
European Journal of Immunology, 2007 Invariant natural killer T (iNKT) cells as we know them today are a unique subset of mature T cells co-expressing a semi-invariant Valpha14/Vbeta8 TCR and surface markers characteristic of NK cells. The semi-invariant TCR on iNKT cells recognizes glycolipids bound to monomorphic CD1d molecules, leading to rapid cytokine production.
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