Results 61 to 70 of about 5,262,931 (244)

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Extracellular adenosine controls NKT-cell-dependent hepatitis induction.

, 2014
Extracellular adenosine regulates inflammatory responses via the A2A adenosine receptor (A2AR). A2AR deficiency results in much exaggerated acute hepatitis, indicating nonredundancy of adenosine-A2AR pathway in inhibiting immune activation. To identify a
Radhika Kini, Michail Sitkovsky, Subramanian, Meenakshi, Akio Ohta, Madasu, Manasa, Michael Nowak, Sitkovsky, Michail, Akiko Ohta, Manasa Madasu, Ohta, Akiko, Nowak, Michael, Ohta, Akio, Exley, Mark, Kini, Radhika, Meenakshi Subramanian, Mark Exley   +15 more
core   +1 more source

Image_1_SFRP4+IGFBP5hi NKT cells induced neural-like cell differentiation to contribute to adenomyosis pain.tif

, 2022
BackgroundAdenomyosis is an estrogen-dependent gynecological disease. The pathogenesis of chronic pain, the main clinical symptom of adenomyosis, remains undefined.
Yichen Chen (4855573), Yuanyuan Shen (570328), Jing Zhang (23775), Liang Chen (73736), Jue Zhu (10957450), Qiming Wang (730892)   +5 more
core   +1 more source

Type II Natural Killer T Cells Contribute to Protection Against Systemic Methicillin-Resistant Staphylococcus aureus Infection

Frontiers in Immunology, 2020
Methicillin-resistant Staphylococcus aureus (SA) bacteremia is responsible for over 10,000 deaths in the hospital setting each year. Both conventional CD4+ T cells and γδ T cells play protective roles in SA infection through secretion of IFN-γ and IL-17.
Samantha Genardi, Lavanya Visvabharathy, Liang Cao, Eva Morgun, Yongyong Cui, Chao Qi, Yi-Hua Chen, Laurent Gapin, Evgeny Berdyshev, Chyung-Ru Wang   +9 more
doaj   +1 more source

B7-H1-deficiency enhances the potential of tolerogenic dendritic cells by activating CD1d-restricted type II NKT cells. [PDF]

PLoS ONE, 2010
BackgroundDendritic cells (DC) can act tolerogenic at a semi-mature stage by induction of protective CD4(+) T cell and NKT cell responses.Methodology/principal findingsHere we studied the role of the co-inhibitory molecule B7-H1 (PD-L1, CD274) on semi ...
Carolin Brandl, Sonja Ortler, Thomas Herrmann, Susanna Cardell, Manfred B Lutz, Heinz Wiendl   +5 more
doaj   +1 more source

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells

, 2003
A major group of murine NK T (NKT) cells express an invariant Valpha14Jalpha18 TCR a-chain specific for glycolipid Ags presented by CD1d. Murine Valpha14alpha18(+) account for 30-50% of hepatic T cells and have potent antitumor activities.
Porcelli, SA, Kenna, T, Koezuka, Y, Golden-Mason, Lucy, Steven A. Porcelli, Tony Kenna, Mason, LG, O'Farrelly, C, Porcelli, Steven A., Hegarty, JE, John E. Hegarty, Koezuka, Yasuhiko, Doherty, DG, Cliona O’Farrelly, Derek G. Doherty, O'Farrelly, Cliona, Hegarty, John E., Kenna, Tony, Doherty, Derek G., Yasuhiko Koezuka, Lucy Golden Mason   +20 more
core   +1 more source

Regulation of NKT cell localization in homeostasis and infection

Frontiers in Immunology, 2015
Natural killer T (NKT) cells are a specialized subset of T lymphocytes that regulate immune responses in the context of autoimmunity, cancer, and microbial infection.
Drew eSlauenwhite, Brent eJohnston, Brent eJohnston, Brent eJohnston   +3 more
doaj   +1 more source

Intrinsic factors and CD1d1 but not CD1d2 expression levels control invariant natural killer T cell subset differentiation

Nature Communications, 2023
Invariant natural killer T (NKT) cell subsets are defined based on their cytokine-production profiles and transcription factors. Their distribution is different in C57BL/6 (B6) and BALB/c mice, with a bias for NKT1 and NKT2/NKT17 subsets, respectively ...
Ludivine Amable, Luis Antonio Ferreira Martins, Remi Pierre, Marcio Do Cruseiro, Ghita Chabab, Arnauld Sergé, Camille Kergaravat, Marc Delord, Christophe Viret, Jean Jaubert, Chaohong Liu, Saoussen Karray, Julien C. Marie, Magali Irla, Hristo Georgiev, Emmanuel Clave, Antoine Toubert, Bruno Lucas, Jihene Klibi, Kamel Benlagha   +19 more
doaj   +1 more source

Cross Talk Between Natural Killer T and Dendritic Cells and Its Impact on T Cell Responses in Infections

Frontiers in Immunology, 2022
Both innate and adaptive immunity is vital for host defense against infections. Dendritic cells (DCs) are critical for initiating and modulating adaptive immunity, especially for T-cell responses.
Lei Zhao, Lei Zhao, Xi Yang
doaj   +1 more source