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Phenotypic characterization of CD8+NKT cells [PDF]
European Journal of Immunology, 2000 We describe a novel CD8(+)NKT cell population expressing TCRalpha /beta or TCRgamma /delta. These CD8(+)NKT cells were prominent in the liver, and except for the thymus, virtually absent in other lymphoid organs. CD8(+)NKT cells expressed activation markers and comprised a high proportion of Ly49(+) cells.
Emoto, M. +4 more
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The role of NKT cells in gastrointestinal cancers [PDF]
OncoImmunology, 2021 Gastrointestinal (GI) cancers represent a complex array of cancers that affect the digestive system. This includes liver, pancreatic, colon, rectal, anal, gastric, esophageal, intestinal and gallbladder cancer. Patients diagnosed with certain GI cancers typically have low survival rates, so new therapeutic approaches are needed. A potential approach is
Julian Burks +2 more
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Differential location of NKT and MAIT cells within lymphoid tissue
Scientific Reports, 2022 Natural Killer T (NKT) cells and Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells that express semi-invariant αβ T cell receptors (TCRs) through which they recognise CD1d and MR1 molecules, respectively, in complex with specific ...
Darryl N. Johnson +14 more
doaj +1 more source
Global Analysis of Dynamic Epigenetic Marking and Transcriptional Regulation Underlying T-Cell Lineage Commitment [PDF]
, 2012 T-cell lineage specification and commitment success depends on precise temporal induction of T-lineage specific genes, as well as repression of lineage-inappropriate programs. After entry into the thymus, T-cell progenitors still retain inherited lineage
Zhang, Jingli A.
core +1 more source
Histone demethylases UTX and JMJD3 are required for NKT cell development in mice
Cell & Bioscience, 2017 Background Natural killer (NK)T cells and conventional T cells share phenotypic characteristic however they differ in transcription factor requirements and functional properties.
Daniel Northrup +10 more
doaj +1 more source
New Directions for Natural Killer T Cells in the Immunotherapy of Cancer
Frontiers in Immunology, 2017 Natural killer T (NKT) cells have been placed at the interface between innate and adaptive immunity by a long series of experiments that convincingly showed that beyond cytokine secretion and NK cell recruitment, NKT cells were coordinating dendritic ...
Luc Teyton
doaj +1 more source
Ameliorated ConA-induced hepatitis in the absence of PKC-theta. [PDF]
PLoS ONE, 2012 Severe liver injury that occurs when immune cells mistakenly attack an individual's own liver cells leads to autoimmune hepatitis. In mice, acute hepatitis can be induced by concanavalin A (ConA) treatment, which causes rapid activation of CD1d-positive ...
Xianfeng Fang +5 more
doaj +1 more source
The Role of Adaptor Proteins in the Biology of Natural Killer T (NKT) Cells
Frontiers in Immunology, 2019 Adaptor proteins contribute to the selection, differentiation and activation of natural killer T (NKT) cells, an innate(-like) lymphocyte population endowed with powerful immunomodulatory properties.
Evelyn Gerth, Jochen Mattner
doaj +1 more source
Natural Killer T and Natural Killer Cell-Based Immunotherapy Strategies Targeting Cancer
Biomolecules, 2023 Both natural killer T (NKT) and natural killer (NK) cells are innate cytotoxic lymphoid cells that produce inflammatory cytokines and chemokines, and their role in the innate immune response to tumors and microorganisms has been investigated. Especially,
Tomonori Iyoda +4 more
doaj +1 more source
, 2006 There is an increasing awareness of the therapeutic potential for combining immune-based therapies with chemotherapy in the treatment of malignant diseases, but few published studies evaluate possible cytotoxic synergies between chemotherapy and ...
Nieda, Mie +7 more
core +1 more source