Results 41 to 50 of about 5,262,931 (244)

Phenotypic characterization of CD8+NKT cells [PDF]

European Journal of Immunology, 2000
We describe a novel CD8(+)NKT cell population expressing TCRalpha /beta or TCRgamma /delta. These CD8(+)NKT cells were prominent in the liver, and except for the thymus, virtually absent in other lymphoid organs. CD8(+)NKT cells expressed activation markers and comprised a high proportion of Ly49(+) cells.
Emoto, M., Zerrahn, J., Miyamoto, M., Perarnau, B., Kaufmann, S.   +4 more
openaire   +3 more sources

Ameliorated ConA-induced hepatitis in the absence of PKC-theta. [PDF]

PLoS ONE, 2012
Severe liver injury that occurs when immune cells mistakenly attack an individual's own liver cells leads to autoimmune hepatitis. In mice, acute hepatitis can be induced by concanavalin A (ConA) treatment, which causes rapid activation of CD1d-positive ...
Xianfeng Fang, Ruiqing Wang, Jian Ma, Yan Ding, Weirong Shang, Zuoming Sun   +5 more
doaj   +1 more source

Development of a deep learning-based 1D convolutional neural network model for cross-species natural killer T cell identification using peripheral blood mononuclear cell single-cell RNA sequencing data [PDF]

Veterinary World
Background and Aim: Natural killer T (NKT) cells exhibit the traits of both T and NK cells. Although their roles have been well studied in humans and mice, limited knowledge is available regarding their roles in dogs and pigs, which serve as models for ...
Kaj Chokeshaiusaha, Thanida Sananmuang, Denis Puthier, Roongtham Kedkovid   +3 more
doaj   +1 more source

New Directions for Natural Killer T Cells in the Immunotherapy of Cancer

Frontiers in Immunology, 2017
Natural killer T (NKT) cells have been placed at the interface between innate and adaptive immunity by a long series of experiments that convincingly showed that beyond cytokine secretion and NK cell recruitment, NKT cells were coordinating dendritic ...
Luc Teyton
doaj   +1 more source

Natural Killer T and Natural Killer Cell-Based Immunotherapy Strategies Targeting Cancer

Biomolecules, 2023
Both natural killer T (NKT) and natural killer (NK) cells are innate cytotoxic lymphoid cells that produce inflammatory cytokines and chemokines, and their role in the innate immune response to tumors and microorganisms has been investigated. Especially,
Tomonori Iyoda, Satoru Yamasaki, Shogo Ueda, Kanako Shimizu, Shin-ichiro Fujii   +4 more
doaj   +1 more source

IL-21 Is Produced by NKT Cells and Modulates NKT Cell Activation and Cytokine Production [PDF]

The Journal of Immunology, 2007
Abstract The common γ-chain cytokine, IL-21, is produced by CD4+ T cells and mediates potent effects on a variety of immune cells including NK, T, and B cells. NKT cells express the receptor for IL-21; however, the effect of this cytokine on NKT cell function has not been studied. We show that IL-21 on its own enhances survival of NKT
Coquet, Jonathan M., Kyparissoudis, Konstantinos, Pellicci, Daniel G., Besra, Gurdyal, Berzins, Stuart P., Smyth, Mark J., Godfrey, Dale I.   +6 more
openaire   +5 more sources

The Role of Adaptor Proteins in the Biology of Natural Killer T (NKT) Cells

Frontiers in Immunology, 2019
Adaptor proteins contribute to the selection, differentiation and activation of natural killer T (NKT) cells, an innate(-like) lymphocyte population endowed with powerful immunomodulatory properties.
Evelyn Gerth, Jochen Mattner
doaj   +1 more source

Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells. [PDF]

PLoS ONE, 2011
Natural killer T (NKT) cells represent an important regulatory T cell subset that develops in the thymus and contains immature (NK1.1(lo)) and mature (NK1.1(hi)) cell subsets.
Mehmet Yabas, Dale I Godfrey, Christopher C Goodnow, Gerard F Hoyne   +3 more
doaj   +1 more source

Chemotherapy pretreatment sensitizes solid tumor-derived cell lines to Vα24+ NKT cell-mediated cytotoxicity

, 2006
There is an increasing awareness of the therapeutic potential for combining immune-based therapies with chemotherapy in the treatment of malignant diseases, but few published studies evaluate possible cytotoxic synergies between chemotherapy and ...
Nieda, Mie, Tony Kenna, Andrew J. Nicol, Nicol, Andrew J., Stephen R. Mattarollo, Mie Nieda, Kenna, Tony, Mattarollo, Stephen R.   +7 more
core   +1 more source

NKT cells in cardiovascular diseases

European Journal of Pharmacology, 2017
Despite life-style advice and the prescription of cholesterol-lowering and anti-thrombotic drugs, cardiovascular diseases are still the leading cause of death worldwide. Therefore, there is an urgent need for new therapeutic strategies focussing on atherosclerosis, the major underlying pathology of cardiovascular diseases characterized by an ...
Puijvelde, G.H.M. van, Kuiper, J.
openaire   +4 more sources