Results 111 to 120 of about 5,262,931 (244)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Extended routine lymphocyte immunophenotyping refines individual immune organization across a heterogeneous patient cohort

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Routine TBNK immunophenotyping detects the major lymphocyte compartments but may underestimate the biologically relevant variation contributed by less frequent but well‐defined minor lymphocyte subsets. This study evaluated whether extending routine TBNK immunophenotyping with minor lymphocyte subsets provides complementary, analytically ...
Carlos Agustin Villegas Valverde, Yendry Ventura Carmenate, Vianed Marsan Suarez, Yandy Marx Castillo Aleman, Imilla Casado Hernandez, Rachely Hernandez Corrales   +5 more
wiley   +1 more source

Maze Puzzle Pattern‐Based Static Reconfiguration of Photovoltaic Arrays for Enhanced Shade Dispersion and Power Generation Under Partial Shading Conditions

Energy Science &Engineering, EarlyView.
A new maze puzzle pattern array (PPA) is presented to optimize shade allocation, alleviate the mismatch losses of PV (photovoltaic) arrays in partially shaded circumstances, and maximize output in partially shaded operation with zero extra sensors, switching components, and optimum searching schemes.
Alok Kumar Shrivastav, Anurag Kar, Milan Sasmal, Pankaj Kumar, Soham Dutta   +4 more
wiley   +1 more source

Comparative gene expression analysis of NKT cell subpopulations

, 2006
Natural killer T (NKT) cells are a lymphocyte lineage, which has diverse immune regulatory activities in many disease settings. Most previous studies have investigated the functions of this family of cells as a single entity, but more recent evidence ...
Hutton, J. F., Rozenkov, V., Lin, H., Nieda, M., Nicol, A. J.   +4 more
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Natural Killer T Cells in Cancer Immunotherapy

Frontiers in Immunology, 2017
Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid antigens. Following stimulation, NKT cells lead to downstream activation of both innate and adaptive immune cells in the tumor microenvironment.
Shiny Nair, Madhav V. Dhodapkar
doaj   +1 more source

Butyrate ameliorates acute‐on‐chronic liver failure by regulating macrophage polarization

iMetaOmics, EarlyView.
Multi‐omics profiling identifies progressive microbiota‐metabolism‐immunity axis dysfunction in acute‐on‐chronic liver failure (ACLF), characterized by gut dysbiosis, reduced butyrate production, intestinal barrier disruption, microbial translocation, and pro‐inflammatory macrophage polarization, thereby exacerbating hepatic inflammation and fibrosis ...
Jing Xiao, Hang You, Zongyi Liu, Yong Sun, Yu Zhang, Li Wei, Ning Ling, Hong Ren, Shiying Li, Peng Hu, Mingli Peng   +10 more
wiley   +1 more source

Interleukin‐37 Enhances Liver NK Cell Cytotoxicity and Improves Recurrence‐Free Survival in Hepatocellular Carcinoma Patients

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Introduction Hepatocellular carcinoma (HCC) remains a major cause of cancer‐related mortality worldwide, and postoperative recurrence continues to limit long‐term survival. Liver‐resident natural killer (NK) cells are key effectors of antitumor immunity in the hepatic microenvironment. Interleukin‐37 (IL‐37), an anti‐inflammatory cytokine, has
Yuki Imaoka, Masahiro Ohira, Yuka Tanaka, Toshihiro Nakayama, Miho Akabane, Shinichiro Yokota, Sheri M. Krams, Olivia M. Martinez, Carlos O. Esquivel, Kazunari Sasaki, Hideki Ohdan   +10 more
wiley   +1 more source

Tunable, High Pulse Energy and Narrow Linewidth Gas‐Filled Fiber Laser Across Near‐ and Mid‐Infrared

Laser &Photonics Reviews, EarlyView.
A cascaded gas‐filled anti‐resonant hollow‐core fiber architecture enables broadly tunable infrared Raman lasers spanning ∼1.4–4.6 µm while maintaining microjoule‐level pulse energies and gigahertz‐level linewidths. The approach combines a wavelength‐tunable pump laser with optimized Raman frequency conversion, providing a compact route to high ...
Yazhou Wang, Marcello Meneghetti, Manoj K. Dasa, Timothy Bate, J. E. Antonio‐Lopez, Ian A. Davidson, Qiang Fu, Jaroslaw Rzegocki, Gregory T. Jasion, Francesco Poletti, Rodrigo Amezcua‐Correa, Christos Markos   +11 more
wiley   +1 more source

NKT cell depletion in humans during early HIV infection

, 2014
Natural killer T (NKT) cells bridge across innate and adaptive immune responses and have an important role in chronic viral infections such as human immunodeficiency virus (HIV).
Kent, SJ, Godfrey, DI, Kelleher, AD ; https://orcid.org/, Fernandez, CS, Finlayson, R   +4 more
core   +1 more source