Results 131 to 140 of about 5,262,931 (244)

The role of natural killer T cells in liver transplantation

Frontiers in Cell and Developmental Biology
Natural killer T cells (NKTs) are innate-like lymphocytes that are abundant in the liver and participate in liver immunity. NKT cells express both NK cell and T cell markers, modulate innate and adaptive immune responses. Type I and Type II NKT cells are
Wenchao Zhao, Mingqian Li, Shifei Song, Yao Zhi, Chen Huan, Guoyue Lv   +5 more
doaj   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Structures of the UBR4 complex reveal a giant arena to capture diverse substrates for ubiquitin chain elongation

The FEBS Journal, EarlyView.
This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley   +1 more source

Pigs lacking Natural Killer T cells have altered cellular responses to influenza.

PLoS Pathogens
It is increasingly recognized that innate T cells such as natural killer T (NKT) cells, mucosal associated invariant T (MAIT) cells, and γδ T cells play an important role in shaping adaptive immune responses following influenza infection or vaccination ...
Taeyong Kwon, Weihong Gu, Igor Morozov, Mariano Carossino, Eu Lim Lyoo, Chester D McDowell, Yonghai Li, Udeni B R Balasuriya, Yi Huang, Darling Melany De Carvahlo Madrid, Kiho Lee, Juergen A Richt, John P Driver   +12 more
doaj   +1 more source

Lysosomal processing of sulfatide analogs alters target NKT cell specificity and immune responses in cancer. [PDF]

J Clin Invest, 2023
Nishio K, Pasquet L, Camara K, DiSapio J, Hsu KS, Kato S, Bloom A, Richardson SK, Welsh JA, Jiang T, Jones JC, Cardell S, Watarai H, Terabe M, Olkhanud PB, Howell AR, Berzofsky JA.   +16 more
europepmc   +1 more source

The Leukocyte Landscape Across Mouse Strains and Tissues

Immunology &Cell Biology, EarlyView.
The blood, bone marrow, liver, lymph nodes, and spleen of naïve male mice contained unique immunobiomes which differed between commonly used strains. BALB‐derived strains exhibited helper‐ and innate‐biased immune profiles, C57BL/6J‐derived strains were enriched for cytotoxic and immune surveillance populations, and DBA/2 J mice displayed elevated γδ T
Ella Trolio, Sarah Dart, Liu Liu, Michaela Lucas, Amy Prosser   +4 more
wiley   +1 more source

Translational Control of NKT Cell Cytokine Production by p38 MAPK

, 2011
NKT cells are known to rapidly produce a large amount of cytokines upon activation. Although a number of signaling pathways that regulate the development of NKT cells have been identified, the signaling pathways involved in the regulation of NKT cell ...
Viswas K. Nagaleekar, Isaac W. Howe, Alan Chant, Patrick J. Benoit, Jonathan E. Boyson, Guadalupe Sabio, Tina M. Thornton, Mercedes Rincon, Roger J. Davis, Idil Aktan   +9 more
core   +1 more source

CAR-NKT cell therapy: a new promising paradigm of cancer immunotherapy. [PDF]

Cancer Cell Int, 2023
Hadiloo K, Tahmasebi S, Esmaeilzadeh A.
europepmc   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source

Type I NKT-cell-mediated TNF-α is a positive regulator of NLRP3 inflammasome priming

, 2014
The NLRP3 inflammasome plays a crucial role in the innate immune response to pathogens and exogenous or endogenous danger signals. Its activity must be precisely and tightly regulated to generate tailored immune responses.
Moller, Andreas, Christelle Faveeuw, Smyth, MJ, Paget, C, Christophe Paget, Chow, Melvyn T., Chow, MT, Andreas Möller, Mark J. Smyth, Andrews, Daniel M., Helene Duret, Daniel M. Andrews, Möller, A, Duret, H, Andrews, DM, Smyth, Mark J., Faveeuw, C, Duret, Helene, Faveeuw, Christelle, Paget, Christophe, Melvyn T. Chow   +20 more
core   +1 more source