Multiple cell-type interactions drive invariant NKT cell hepatitis. [PDF]
Tan J +15 more
europepmc +1 more source
Use of a Clostridioides difficile Murine Immunization and Challenge Model to Evaluate Single and Combination Vaccine Adjuvants Consisting of Alum and NKT Cell-Activating Ligands. [PDF]
Lang GA +5 more
europepmc +1 more source
TCF/LEF family transcription factors: Molecular landscape and prognostic scoring in pan‐cancer
This study provides a comprehensive molecular landscape of TCF/LEF family transcription factors across 33 cancer types. We developed a TCF/LEF‐based prognostic score that correlates with immune infiltration, metabolic reprogramming and drug sensitivity, offering a robust transcriptomic signature for predicting patient survival and therapeutic response.
Zhengjun Yang +8 more
wiley +1 more source
The α glycolipid rules the NKT cell TCR. [PDF]
Kronenberg M, Ascui G.
europepmc +1 more source
Unexpected Pro-Fibrotic Effect of MIF in Non-Alcoholic Steatohepatitis Is Linked to a Shift in NKT Cell Populations. [PDF]
Heinrichs D +15 more
europepmc +1 more source
The Dual Role of the Gut Microbiota in Cancer Chemoresistance
Comparison between Microbiota and Cancer therapy. ABSTRACT Chemoresistance is one of the primary reasons that cancer chemotherapy fails to deliver successful treatment outcomes and contributes to poor overall survival rates for patients with cancer. New research has begun to shed light on the effects of the gut microbiome (GM).
Hamed Tahmasebi +3 more
wiley +1 more source
Differential Immune Checkpoint Expression in CD4<sup>+</sup> and CD4<sup>-</sup> NKT Cell Populations During Healthy Pregnancy. [PDF]
Meggyes M +5 more
europepmc +1 more source
Turning Cold Tumors Into Hot Tumors: Implications for Cancer Therapy
Barrier‐defined strategies for cold‐to‐hot tumor conversion. Cold tumors include immune‐desert and immune‐excluded states marked by poor antigen visibility, limited T‐cell priming, stromal or vascular exclusion, metabolic stress and suppressive immune programs.
Xiao Ge +5 more
wiley +1 more source
Patient-Derived Organoid Models for NKT Cell-Based Cancer Immunotherapy. [PDF]
Palacios PA +7 more
europepmc +1 more source
CCL20 Released by Drug–Tolerant Persisters Impairs Immunotherapy in EGFR–Mutant Lung Adenocarcinoma
Schematic representation of tumor immune microenvironment (TIME) modulation by combined anti‐PD‐1 and anti‐CCL20 therapies. Left: In the “cold” tumor TIME, high CCL20 secretion by drug‐tolerant persister (DTP) cancer cell subpopulations promotes regulatory T cell (Treg) enrichment and clusters in close proximity to tumor cells, resulting in immune ...
Hoi‐Hin Kwok +4 more
wiley +1 more source

