Results 121 to 130 of about 5,157 (213)
Extracellular adenosine controls NKT-cell-dependent hepatitis induction.
, 2014 Extracellular adenosine regulates inflammatory responses via the A2A adenosine receptor (A2AR). A2AR deficiency results in much exaggerated acute hepatitis, indicating nonredundancy of adenosine-A2AR pathway in inhibiting immune activation. To identify a
Radhika Kini +15 more
core +1 more source
British Journal of Mathematical and Statistical Psychology, EarlyView.Abstract Hidden Markov diagnostic classification models capture how students' cognitive attributes evolve over time. This paper introduces a Bayesian Markov chain Monte Carlo algorithm for diagnostic classification models that jointly estimates time‐varying Q matrices, latent attributes, item parameters, attribute class proportions and transition ...
Chen‐Wei Liu
wiley +1 more source
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
Regulation of nkt cell metabolism by plzf
, 2018 Cellular metabolism and signaling pathways are the key regulators to determine T cell fate, survival and function, particularly during activation. Resting CD4 and CD8 T cells use oxidative phosphorylation as a primary energy source but switches to ...
Giri, Shailendra +4 more
core
NKT cell activation by diverse antigens and antigen-presenting cells
, 2013 © 2013 Dr. Fiona Jean RossPublications included in thesis:Wun, K. S., Ross, F., Patel, O., Besra, G. S., Porcelli, S. A., Richardson, S. K., et al. (2012).
Ross, Fiona Jean
core +1 more source
Cancer Science, EarlyView.Chemotherapy combined with nivolumab reshapes the gastric cancer tumor microenvironment (TME) and is accompanied by an enrichment of reduced cytotoxicity NK (RC‐NK) cells. Rather than acting as classical cytotoxic effectors, these RC‐NK cells appear to shape the TME by promoting an immunostimulatory circuit that engages adaptive immunity.
Takuya Nakatsuru +24 more
wiley +1 more source
Repertoire selection and effector differentiation during NKT cell development
, 2012 Natural killer T (NKT) cells are innate-like lymphocytes that develop and mature in the thymus. From there, they home to the peripheral lymphoid tissues where, in some cases, they can finalise the maturation program. NKT cells function by close cell-cell
Gordy, Laura Elizabeth
core
Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma
The FEBS Journal, EarlyView.IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture +3 more
wiley +1 more source
Cytotoxic capability of NKT cell subsets.
, 2013 Experiments were performed in triplicate per donor; standard deviation is depicted. For A, B, C, and D, one representative donor out of three independent experiments is shown.
Mark S. Sundrud (67590) +5 more
core +1 more source
Immunology &Cell Biology, EarlyView.VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez +10 more
wiley +1 more source