Results 11 to 20 of about 5,262,931 (244)
NKT Cell Responses to B Cell Lymphoma [PDF]
Medical Sciences, 2014 Natural killer T (NKT) cells are a unique subset of CD1d-restricted T lymphocytes that express characteristics of both T cells and natural killer cells.
Junxin Li +8 more
doaj +4 more sources
NK and NKT cell functions in immunosenescence [PDF]
Aging Cell, 2004 Immunosenescence is defined as the state of dysregulated immune function that contributes to the increased susceptibility to infection, cancer and autoimmune diseases observed in old organisms, including humans.
Malavolta M., Mocchegiani E.
core +4 more sources
NKT Cells in Neurological Diseases [PDF]
Frontiers in Cellular Neuroscience, 2019 Natural killer T (NKT) cells are a unique subset of T lymphocytes with the expression of T cell receptor (TCR) and NK cell lineage receptors. These cells can rapidly release large quantities of cytokines and function as a bridge between innate and ...
Yu Cui, Qi Wan
doaj +3 more sources
Frontiers in Cell and Developmental Biology, 2020 Vα24-invariant human natural killer T (NKT) cells comprise a unique subset of CD1d-restricted T cells with potent immune regulatory function and are involved in the development of a variety of human diseases.
Li Zhou +9 more
doaj +3 more sources
EBV promotes human CD8 NKT cell development. [PDF]
PLoS Pathogens, 2010 The reports on the origin of human CD8(+) Valpha24(+) T-cell receptor (TCR) natural killer T (NKT) cells are controversial. The underlying mechanism that controls human CD4 versus CD8 NKT cell development is not well-characterized.
Yuling He +14 more
doaj +2 more sources
Harnessing NKT cells for vaccination [PDF]
Oxford Open Immunology, 2021 Lay Summary Vaccine-induced immune responses generally involve activation of immune cells called T and B cells that have a variety of mechanisms to limit the infection. Each T or B cell has a randomly generated receptor for binding pathogen-derived antigens, but only a few cells with an individual’s repertoire of cells will recognize a ...
Olivia K Burn +4 more
openaire +2 more sources
The Role of NKT Cells in Glioblastoma [PDF]
Cells, 2021 Glioblastoma is an aggressive and deadly cancer, but to date, immunotherapies have failed to make significant strides in improving prognoses for glioblastoma patients. One of the current challenges to developing immunological interventions for glioblastoma is our incomplete understanding of the numerous immunoregulatory mechanisms at play in the ...
Emily E. S. Brettschneider +1 more
openaire +3 more sources
Description of invariant NKT cells.
Journal of Education, Health and Sport, 2021 Recently discovered subpopulations belonging to cell groups called “invariant” NKT, also referred to as type I NKT or classical NKT cells, appear to have a unique impact on the tumor microenvironment. Considering the characteristics of secreted cytokines, production of chemokines and the capability of cell cytotoxic activity, these cells have a ...
Katarzyna Karwicka +2 more
openaire +4 more sources
Regulation of NKT Cells by Ly49: Analysis of Primary NKT Cells and Generation of NKT Cell Line [PDF]
The Journal of Immunology, 2001 Abstract TCRαβ+NK1.1+ (NKT) cells are known to express various NK cell-associated molecules including the Ly49 family of receptors for MHC class I, but its functional significance has been unclear. Here, we examined the expression of Ly49A, C/I and G2 on various NKT cell populations from normal and MHC class I-deficient C57BL/6 mice ...
M, Maeda +3 more
openaire +2 more sources
Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression. [PDF]
Cancers (Basel), 2021 Drugs selectively targeting replication stress have demonstrated significant preclinical activity, but this has not yet translated into an effective clinical treatment.
Proctor M +12 more
europepmc +3 more sources