Results 11 to 20 of about 4,918,459 (222)

EBV promotes human CD8 NKT cell development. [PDF]

PLoS Pathogens, 2010
The reports on the origin of human CD8(+) Valpha24(+) T-cell receptor (TCR) natural killer T (NKT) cells are controversial. The underlying mechanism that controls human CD4 versus CD8 NKT cell development is not well-characterized.
Yuling He, Ruijing Xiao, Xiang Ji, Li Li, Lang Chen, Jie Xiong, Wei Xiao, Yujuan Wang, Lijun Zhang, Rui Zhou, Xinti Tan, Yongyi Bi, Yan-Ping Jiang, Youxin Jin, Jinquan Tan   +14 more
doaj   +2 more sources

Regulation of NKT cell localization in homeostasis and infection

Frontiers in Immunology, 2015
Natural killer T (NKT) cells are a specialized subset of T lymphocytes that regulate immune responses in the context of autoimmunity, cancer, and microbial infection.
Drew eSlauenwhite, Brent eJohnston, Brent eJohnston, Brent eJohnston   +3 more
doaj   +2 more sources

Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression. [PDF]

Cancers (Basel), 2021
Drugs selectively targeting replication stress have demonstrated significant preclinical activity, but this has not yet translated into an effective clinical treatment.
Proctor M, Gonzalez Cruz JL, Daignault-Mill SM, Veitch M, Zeng B, Ehmann A, Sabdia M, Snell C, Keane C, Dolcetti R, Haass NK, Wells JW, Gabrielli B.   +12 more
europepmc   +2 more sources

Transfer of mRNA Encoding Invariant NKT Cell Receptors Imparts Glycolipid Specific Responses to T Cells and γδT Cells. [PDF]

PLoS ONE, 2015
Cell-based therapies using genetically engineered lymphocytes expressing antigen-specific T cell receptors (TCRs) hold promise for the treatment of several types of cancers.
Kanako Shimizu, Jun Shinga, Satoru Yamasaki, Masami Kawamura, Jan Dörrie, Niels Schaft, Yusuke Sato, Tomonori Iyoda, Shin-Ichiro Fujii   +8 more
doaj   +1 more source

IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production

, 2007
The common gamma-chain cytokine, IL-21, is produced by CD4(+) T cells and mediates potent effects on a variety of immune cells including NK, T, and B cells.
Berzins, SP, Godfrey, DI, Coquet, JM, Kyparissoudis, K, Besra, Gurdyal; id_orcid, Smyth, MJ, Pellici, DG   +6 more
core   +7 more sources

Efficient isolation of mouse liver NKT cells by perfusion. [PDF]

PLoS ONE, 2010
BACKGROUND: NKT cell is a population of unconventional T cells that mediate both innate and adaptive T cell responses. Since NKT cells are most abundant in the liver, much of NKT biology has been learnt from studies of NKT cells isolated from liver. This
Xianfeng Fang, Peishuang Du, Yang Liu, Jie Tang   +3 more
doaj   +1 more source

Pro-inflammatory activated Kupffer cells by lipids induce hepatic NKT cells deficiency through activation-induced cell death. [PDF]

PLoS ONE, 2013
BACKGROUND: Dietary lipids play an important role in the progression of non-alcoholic fatty liver disease (NAFLD) through alternation of liver innate immune response.
Tongfang Tang, Yongheng Sui, Min Lian, Zhiping Li, Jing Hua   +4 more
doaj   +1 more source

Cord blood Vα24-Vβ11 natural killer T cells display a Th2-chemokine receptor profile and cytokine responses [PDF]

, 2011
Background: The fetal immune system is characterized by a Th2 bias but it is unclear how the Th2 predominance is established. Natural killer T (NKT) cells are a rare subset of T cells with immune regulatory functions and are already activated in utero ...
Elfriede Noessner, Krauss-Etschmann, S., Faber Fabienne L., Harner, Susanne, Harner, S., Nadas, Korinna, Leumann-Runge Anke, Leumann-Runge, A., Leumann-Runge, Anke, Susanne Harner, Korinna Nadas, Nadas, K., Joachim Heinrich, Heinrich, Joachim, Fabienne L Faber, Nadas Korinna, Heinrich, J., Noessner Elfriede, Noessner, Elfriede, Anke Leumann-Runge, Schiemann, Matthias, Susanne Krauss-Etschmann, Krauss-Etschmann Susanne, Fabienne L. Faber, Schiemann Matthias, Nößner, E., Faber, Fabienne L., Krauss-Etschmann, Susanne, Schiemann, M., Faber, F.L., Heinrich Joachim, Harner Susanne, Matthias Schiemann, Harner, S;Noessner, E;Nadas, K;Leumann-Runge, A;Schiemann, M;Faber, FL;Heinrich, J;Krauss-Etschmann, S   +33 more
core   +2 more sources

The Role of Natural Killer T Cells in Cancer—A Phenotypical and Functional Approach

Frontiers in Immunology, 2018
Natural killer T (NKT) cells are a subset of CD1d-restricted T cells at the interface between the innate and adaptive immune system. NKT cells can be subdivided into functional subsets that respond rapidly to a wide variety of glycolipids and stress ...
Daniëlle Krijgsman, Daniëlle Krijgsman, Marianne Hokland, Peter J. K. Kuppen   +3 more
doaj   +1 more source

NKT Cells Contribute to the Control of Microbial Infections

Frontiers in Cellular and Infection Microbiology, 2021
Innate (-like) T lymphocytes such as natural killer T (NKT) cells play a pivotal role in the recognition of microbial infections and their subsequent elimination.
Stefan Vogt, Jochen Mattner, Jochen Mattner   +2 more
doaj   +1 more source