NKT Cells in Neurological Diseases [PDF]
Frontiers in Cellular Neuroscience, 2019 Natural killer T (NKT) cells are a unique subset of T lymphocytes with the expression of T cell receptor (TCR) and NK cell lineage receptors. These cells can rapidly release large quantities of cytokines and function as a bridge between innate and ...
Yu Cui, Qi Wan
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IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production [PDF]
The Journal of Immunology, 2007 The common γ-chain cytokine, IL-21, is produced by CD4 T cells and mediates potent effects on a variety of immune cells including NK, T, and B cells. NKT cells express the receptor for IL-21; however, the effect of this cytokine on NKT cell function has ...
Godfrey, DI +13 more
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The Role of NKT Cells in Glioblastoma [PDF]
Cells, 2021 Glioblastoma is an aggressive and deadly cancer, but to date, immunotherapies have failed to make significant strides in improving prognoses for glioblastoma patients. One of the current challenges to developing immunological interventions for glioblastoma is our incomplete understanding of the numerous immunoregulatory mechanisms at play in the ...
Emily E. S. Brettschneider +1 more
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Harnessing NKT cells for vaccination [PDF]
Oxford Open Immunology, 2021 Lay Summary Vaccine-induced immune responses generally involve activation of immune cells called T and B cells that have a variety of mechanisms to limit the infection. Each T or B cell has a randomly generated receptor for binding pathogen-derived antigens, but only a few cells with an individual’s repertoire of cells will recognize a ...
Olivia K Burn +4 more
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The interaction between regulatory T cells and NKT cells in the liver: a CD1d bridge links innate and adaptive immunity. [PDF]
PLoS ONE, 2011 Regulatory T cells (Tregs) and natural killer T (NKT) cells are two distinct lymphocyte subsets that independently regulate hepatic adaptive and innate immunity, respectively.
Jing Hua +5 more
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B-cell lymphopoiesis is regulated by cathepsin L. [PDF]
PLoS ONE, 2013 Cathepsin L (CTSL) is a ubiquitously expressed lysosomal cysteine peptidase with diverse and highly specific functions. The involvement of CTSL in thymic CD4+ T-cell positive selection has been well documented.
Maria Noel Badano +8 more
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Regulation of NKT Cells by Ly49: Analysis of Primary NKT Cells and Generation of NKT Cell Line [PDF]
The Journal of Immunology, 2001 Abstract TCRαβ+NK1.1+ (NKT) cells are known to express various NK cell-associated molecules including the Ly49 family of receptors for MHC class I, but its functional significance has been unclear. Here, we examined the expression of Ly49A, C/I and G2 on various NKT cell populations from normal and MHC class I-deficient C57BL/6 mice ...
M, Maeda +3 more
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Identification of CD4(-)CD8(-) double-negative natural killer T cell precursors in the thymus. [PDF]
PLoS ONE, 2008 BACKGROUND: It is well known that CD1d-restricted Valpha14 invariant natural killer T (NKT) cells are derived from cells in the CD4(+)CD8(+) double-positive (DP) population in the thymus. However, the developmental progression of NKT cells in the earlier
Nyambayar Dashtsoodol +3 more
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Choline Deficiency Causes Colonic Type II Natural Killer T (NKT) Cell Loss and Alleviates Murine Colitis under Type I NKT Cell Deficiency. [PDF]
PLoS ONE, 2017 Serum levels of choline and its derivatives are lower in patients with inflammatory bowel disease (IBD) than in healthy individuals. However, the effect of choline deficiency on the severity of colitis has not been investigated.
Shintaro Sagami +9 more
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Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions. [PDF]
PLoS ONE, 2006 Natural killer T (NKT) cells are a subset of T cells that help potentiate and regulate immune responses. Although human NKT cell subsets with distinct effector functions have been identified, it is unclear whether the effector functions of these subsets ...
Karla A Eger +5 more
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