Results 121 to 130 of about 20,572 (218)
The Pathophysiological Relevance of the iNKT Cell/Mononuclear Phagocyte Crosstalk in Tissues
Frontiers in Immunology, 2018 CD1d-restricted Natural Killer T (NKT) cells are regarded as sentinels of tissue integrity by sensing local cell stress and damage. This occurs via recognition of CD1d-restricted lipid antigens, generated by stress-related metabolic changes, and ...
Filippo Cortesi +4 more
doaj +1 more source
Does an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma? [PDF]
, 2016 Natural killer T (NKT) cells constitute a unique subset of innate-like T lymphocytes which differ from conventional T cells by recognizing lipid antigens presented by the non-polymorphic major histocompatibility complex (MHC) I-like molecule CD1d ...
Elewaut, Dirk +4 more
core +2 more sources
CD1d knockout swine are permissive to African swine fever virus genotype II infection
Emerging Microbes and InfectionsAfrican swine fever virus (ASFV) is an important pathogen of domestic and wild suids and the causative agent of African swine fever (ASF). ASFV displays a tropism for myeloid cells, predominately of the monocyte/macrophage lineage, which is critical for ...
Daniel Madden +15 more
doaj +1 more source
CD1b Tetramers Bind \(\alpha \beta\) T Cell Receptors to Identify a Mycobacterial Glycolipid-Reactive T Cell Repertoire in Humans [PDF]
, 2013 Microbial lipids activate T cells by binding directly to CD1 and T cell receptors (TCRs) or by indirect effects on antigen-presenting cells involving induction of lipid autoantigens, CD1 transcription, or cytokine release. To distinguish among direct and
Altman, John D. +14 more
core +1 more source
Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer
Molecules, 2014 Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T ...
Meena S. Thakur +3 more
doaj +1 more source
A Fungal Glycosphingolipid Directly Activates Natural Killer T Cells and Rapidly Induces Airways Disease [PDF]
, 2014 Aspergillus fumigatusis a saprophytic fungus that is ubiquitous in the environment and commonly associated with allergic sensitization and severe asthma in humans. Although A.
Albacker, Lee A. +8 more
core +1 more source
Aberrant Presentation of Self-Lipids by Autoimmune B Cells Depletes Peripheral iNKT Cells
Cell Reports, 2014 Summary: Invariant natural killer T (iNKT) cells provide cognate help via CD1d to lipid antigen-presenting B cells for antibody production, but whether B cells reciprocally regulate iNKT cells remains largely unexplored.
Andy Hee-Meng Tan +5 more
doaj +1 more source
Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens
Nature Communications, 2016 The invariant αβTCR of type I NKT cells recognizes a lipid α-GalCer presented by CD1d. Here the authors describe atypical α-GalCer-reactive NKT cells with diverse TCRs, which bind to CD1d-α-GalCer in a manner distinct from type I NKT cells, thus ...
Jérôme Le Nours +13 more
doaj +1 more source