Results 141 to 150 of about 10,329 (179)

CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity

open access: yesExperimental Dermatology, 2005
Abstract:  CD1d‐restricted T‐cells are activated by glycolipids presented by the major histocompatibility complex class‐Ib molecule CD1d, found on the surface of antigen‐presenting cells (APC). This interaction between APC, most notably dendritic cells (DC), and CD1d‐restricted T‐cells is an important regulatory step in the initiation of adaptive ...
Silke Gillessen   +2 more
exaly   +7 more sources

Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex

open access: yesVirology, 2005
The HIV-1 Nef protein causes a decrease in major histocompatibility complex (MHC) class I and CD4 molecule expression on the cell surface. To determine if Nef can affect components of the innate immune response, we assessed the ability of Nef to alter the cell surface expression of human CD1d.
Kenneth S Knox   +2 more
exaly   +3 more sources
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Tissue-Specific Segregation of CD1d-Dependent and CD1d-Independent NK T Cells

The Journal of Immunology, 1999
Abstract NKT cells, defined as T cells expressing the NK cell marker NK1.1, are involved in tumor rejection and regulation of autoimmunity via the production of cytokines. We show in this study that two types of NKT cells can be defined on the basis of their reactivity to the monomorphic MHC class I-like molecule CD1d. One type of NKT
Eberl, R   +5 more
openaire   +2 more sources

Adipocyte CD1d Gene Transfer Induces T Cell Expansion and Adipocyte Inflammation in CD1d Knockout Mice

The Journal of Immunology, 2022
Abstract CD1d, a lipid Ag-presenting molecule for invariant NKT (iNKT) cells, is abundantly expressed on adipocytes and regulates adipose homeostasis through iNKT cells. CD1d gene expression was restored in visceral adipose tissue adipocytes of CD1d knockout (KO) mice to investigate the interactions between adipocytes and immune cells ...
Run Xiao   +15 more
openaire   +2 more sources

The yin and yang of CD1d recognition

Nature Immunology, 2012
Structural studies identify considerable differences in the recognition of CD1d-lipid complexes by the TCRs of type II and type I (invariant) natural killer T cells.
Erin J Adams, Adrienne M Luoma
openaire   +1 more source

Roles of CD1d-restricted NKT cells in the intestine

Inflammatory Bowel Diseases, 2007
Natural killer T (NKT) cells are a subset of lymphocytes that express cell surface molecules of both conventional T cells and natural killer cells and share the features of both innate and adaptive immune cells. NKT cells have been proposed to make both protective and pathogenic contributions to inflammatory bowel diseases (IBD).
Dieren, Jolanda   +6 more
openaire   +3 more sources

The role of CD1d transmembrane and cytoplasmic tail domain in CD1d trafficking pathway

2015
CD1 molecules are a family of MHC class I-like lipid presenting molecules. They could specifically recognize self lipid antigens and extracellular lipid antigens, and present them to T lymphocytes. T lymphocytes are stimulated to secrete different cytokines to execute their immunological functions. CD1d, a member of CD1 family, exists both in human and
openaire   +1 more source

Assignment of the evolutionarily conserved CD1D class gene (Cd1d) to rat chromosome 7q32

Cytogenetics and Cell Genetics, 2008
A, Matsuura   +6 more
openaire   +2 more sources

The Regulation of CD1d+ and CD1d− Tumors by NKT Cells

2011
Jianyun Liu   +2 more
openaire   +1 more source

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