Critical role of NKT cells in posttransplant alloantibody production [PDF]
, 2014 We previously reported that posttransplant alloantibody production in CD8-deficient hosts is IL-4+ CD4+ T cell-dependent and IgG1 isotype-dominant. The current studies investigated the hypothesis that IL-4-producing natural killer T cells (NKT cells ...
Abdel-Rasoul, M. +7 more
core +1 more source
Diverse immunological roles of liver‐resident immune cells in liver diseases
Precision Medical Sciences, Volume 15, Issue 1, Page 4-17, March 2026.Based on their origin and functional characteristics, LRICs can be classified into four categories. These cells differ in the focus of their immune functions in liver diseases, yet all exhibit the characteristic of functional bidirectionality.
Zhengyi Fan +4 more
wiley +1 more source
Alpha-Galactosylceramide/CD1d-Antibody Fusion Proteins Redirect Invariant Natural Killer T Cell Immunity to Solid Tumors and Promote Prolonged Therapeutic Responses. [PDF]
, 2017 Major progress in cancer immunotherapies have been obtained by the use of tumor targeting strategies, in particular with the development of bi-functional fusion proteins such as ImmTacs or BiTes, which engage effector T cells for targeted elimination of ...
Donda, A., Zhang, L.
core +1 more source
Advances in the Role of Adipose Tissue in Promoting Injury Repair and Resist Infection
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.ABSTRACT Background In recent years, adipose tissue (AT) transplantation has increasingly been noticed by many people in the field of tissue repair and regeneration. Accumulating evidence demonstrates that AT exerts dual functions in promoting tissue repair and conferring anti‐infective properties, with distinct biological effects attributed to its ...
Xi Duan +4 more
wiley +1 more source
Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex
Virology, 2005 The HIV-1 Nef protein causes a decrease in major histocompatibility complex (MHC) class I and CD4 molecule expression on the cell surface. To determine if Nef can affect components of the innate immune response, we assessed the ability of Nef to alter the cell surface expression of human CD1d.
Cho, Sungyoo +6 more
openaire +2 more sources
Immune cells and preterm labour:do invariant NKT cells hold the key? [PDF]
, 2015 We have developed our original made-to-measure (M2M) algorithm, PRIMAL, with the aim of modelling the Galactic disc from upcoming Gaia data. From a Milky Way like N-body disc galaxy simulation, we have created mock Gaia data using M0III stars as tracers,
Rinaldi, S F +3 more
core +3 more sources
A virologist’s guide to hide and seek : evasion of innate immunity by primate lentiviruses [PDF]
, 2015 HIV is the cause of a chronic, incurable infection in 37 million people worldwide in 2014. This thesis investigates how the immune system detects HIV and how in turn HIV avoids detection by the immune system.
Bächle, Susanna M
core +1 more source
Contribution of NKT cells to the immune response and pathogenesis triggered by respiratory viruses
Virulence, 2020 Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) cause acute respiratory tract infections in children worldwide. Natural killer T (NKT) cells are unconventional T lymphocytes, and their TCRs recognize glycolipids bound to the MHC-
Emma Rey-Jurado +6 more
doaj +1 more source
Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function [PDF]
, 2018 MHC class I-like CD1 molecules have evolved to present lipid-based antigens to T cells. Differences in the antigen-binding clefts of the CD1 family members determine the conformation and size of the lipids that are presented, although the factors that ...
Bradbury +22 more
core +4 more sources
Cancer Medicine, 2019 Background Anaplastic thyroid carcinomas are associated with rapid tumor growth, short survival time and without any promising therapy to improve the poor prognosis.
Florian Weber +6 more
doaj +1 more source