Results 111 to 120 of about 13,147 (200)

IFN-gamma modulates CD1d surface expression on intestinal epithelia

, 1996
In vivo, epithelial cells that line the intestine are intimately associated with lymphocytes, termed intestinal intraepithelial lymphocytes (iIEL).
J. E. Polischuk, S. P. Colgan, J. L. Madara, V. M. Morales, S. P. Balk, R. S. Blumberg   +5 more
core   +1 more source

Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens

Nature Communications, 2016
The invariant αβTCR of type I NKT cells recognizes a lipid α-GalCer presented by CD1d. Here the authors describe atypical α-GalCer-reactive NKT cells with diverse TCRs, which bind to CD1d-α-GalCer in a manner distinct from type I NKT cells, thus ...
Jérôme Le Nours, T. Praveena, Daniel G. Pellicci, Nicholas A. Gherardin, Fiona J. Ross, Ricky T. Lim, Gurdyal S. Besra, Santosh Keshipeddy, Stewart K. Richardson, Amy R. Howell, Stephanie Gras, Dale I. Godfrey, Jamie Rossjohn, Adam P. Uldrich   +13 more
doaj   +1 more source

The CDR3β loop strongly impacts on human iNKT TCR affinity to CD1d, independent of the CD1d-bound ligand.

, 2013
(A) Binding of two recombinant human iNKT TCRs, one OCHHIGH (4C1369) and one OCHLOW (4C12), to K7-, OCH-, βGC-, and LacCer-CD1d at equilibrium is shown (see also panel C and Table 2).
Daniel Schümperli (27023), Gopal R. Bommineni (363741), Gediminas Matulis (363733), Nikolai M. Lissin (363736), Peter M. Villiger (206223), Joseph P. Sanderson (363734), Maria B. Asparuhova (363738), Stephan D. Gadola (363749), Bent K. Jakobsen (363747), Richard R. Schmidt (363744)   +9 more
core   +1 more source

Innate Immune Response to Encephalomyocarditis Virus Infection Mediated by CD1d

, 2003
CD1d-reactive natural killer T (NKT) cells can rapidly produce T helper type 1 (Th1) and/or Th2 cytokines, can activate antigen-presenting cell (APC) interleukin-12 (IL-12) production, and are implicated in the regulation of adaptive immune responses ...
Angela Shaulov, Wang, Carren, Shaulov, Angela, Garcia, Jorge, Nancy J. Bigley, Scott B. Snapper, Harold F. Stills, Patten, Kurt, Olivia Cheng, Syed Muhammad Ali Tahir, Carter, Quincy L., Stills, Harold F., Mark A. Exley, Bigley, Nancy J., Carren Wang, Cheng, Olivia, Tahir, Syed Muhammad Ali, Exley, Mark A., Kurt Patten, Stills, Harold F., Jr., Jorge Garcia, Snapper, Scott B., Quincy L. Carter, Balk, Steven P., Steven P. Balk, Frederick W. Alt, Alt, Frederick W.   +26 more
core   +1 more source

Activation of mouse NKT cells by CD1d orthologs.

, 2012
Activation of mouse iNKT hybridomas 1.2 by recombinant human, mouse and bovine CD1d in a CD1d-coated plate assay, using either αGalCer (top) or C16-αGalCer (C16, bottom). Individual amino acid mutations in CD1d are indicated.
Nora Pauwels (125211), Serge Van Calenbergh (125212), Jing Wang (4865), Joren Guillaume (125210), Ildiko Van Rhijn (125214), Dirk M. Zajonc (125216)   +5 more
core   +1 more source

The role of CD1d in adipogenesis

, 2007
Atherosclerosis-associated coronary heart disease is the number one cause of death in the western society, and often triggered by metabolic disorders, such as hyperlipidemia, hypertension, obesity, and diabetes.
Rosales, Corina
core  

Structure and binding kinetics of three different human CD1d-?-galactosylceramide-specific T cell receptors

, 2006
Invariant human TCR V?24-J?18+/Vbeta11+ NKT cells (iNKT) are restricted by CD1d-?-glycosylceramides. We analyzed crystal structures and binding characteristics for an iNKT TCR plus two CD1d-?-GalCer-specific Vbeta11+ TCRs that use different TCR Valpha ...
Peter M. Villiger, E. Yvonne Jones, Gadola, Stephan D., Jones, E. Yvonne, Villiger, PM, Lissin, Nikolai M., Jakobsen, BK, Jon Marles-Wright, Jakobsen, Bent K., Koch, M, Marles-Wright, J, Cerundolo, Vincenzo, Stuart, David I., Lissin, NM, Marles-Wright, Jon, Cerundolo, V, Matulis, Gediminas, Gediminas Matulis, Karl Harlos, Stuart, David, Koch, Michael, Stuart, David I, Stephan D. Gadola, Jones, EY, Harlos, Karl, David I. Stuart, Michael Koch, Jakobsen, Bent K, Vincenzo Cerundolo, Lissin, Nikolai M, Jones, Edith, Gadola, SD, Villiger, Peter M, Shepherd, D, Harlos, K, Gadola, Stephan D, Jones, E Yvonne, Bent K. Jakobsen, Villiger, Peter M., Matulis, G, Dawn Shepherd, Shepherd, Dawn, Nikolai M. Lissin, Stuart, DI   +43 more
core   +1 more source

CD1d [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Role of CD1d and iNKT cells in regulating intestinal inflammation

Frontiers in Immunology
Invariant natural killer T (iNKT) cells, a subset of unconventional T cells that recognize glycolipid antigens in a CD1d-dependent manner, are crucial in regulating diverse immune responses such as autoimmunity.
Sung Won Lee, Hyun Jung Park, Luc Van Kaer, Seokmann Hong   +3 more
doaj   +1 more source

CD1d-specific single-domain antibodies for unconventional immunomodulation [PDF]

Bispecific T cell engagers (bsTCEs) in clinical development and/or (recently) approved as standard of care, face challenges related to the bsTCE format (e.g half-life, tumor penetration, immunogenicity, stability) and targeted effector cells population ...
Lameris, Roeland
core   +1 more source