Results 71 to 80 of about 13,147 (200)
PLoS Pathogens, 2023 One of the major pathogenesis mechanisms of SARS-CoV-2 is its potent suppression of innate immunity, including blocking the production of type I interferons.
Hongjia Lu +13 more
doaj +1 more source
Human CD1D Gene Expression Is Regulated by LEF-1 through Distal Promoter Regulatory Elements [PDF]
, 2010 CD1d-expressing cells present lipid Ag to CD1d-restricted NKT cells, which play an important role in immune regulation and tumor rejection. Lymphoid enhancer-binding factor-1 (LEF-1) is one of the regulators of the Wnt signaling pathway, which is a ...
Chen, Qiao-Yi +8 more
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Regulatory Role of CD1d in Neurotropic Virus Infection [PDF]
Journal of Virology, 2008 ABSTRACTThe GDVII strain of Theiler's murine encephalomyelitis virus (TMEV) causes an acute fatal polioencephalomyelitis in mice. Infection of susceptible mice with the DA strain of TMEV results in an acute polioencephalomyelitis followed by chronic immune-mediated demyelination with virus persistence in the central nervous system (CNS); DA virus ...
Ikuo, Tsunoda +2 more
openaire +2 more sources
CD1d-mediated lipid presentation by CD11c+ cells regulates intestinal homeostasis
, 2020 Intestinal homeostasis relies on a continuous dialogue between the commensal bacteria and the immune system. Natural killer T (NKT) cells, which recognize CD1d-restricted microbial lipids and self-lipids, contribute to the regulation of mucosal immunity,
Rebeca Jimeno (8348862) +7 more
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Veterinary Dermatology, Volume 37, Issue 3, Page 353-364, June 2026.ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon +5 more
wiley +1 more source
Immune evasion of the CD1d/NKT cell axis [PDF]
Current Opinion in Immunology, 2018 Many reviews on the CD1d/NKT cell axis focus on the ability of CD1d-restricted NKT cells to serve as effector cells in a variety of disorders, be they infectious diseases, cancer or autoimmunity. In contrast, here, we discuss the ways that viruses, bacteria and tumor cells can evade the CD1d/NKT cell axis.
Brutkiewicz, Randy R. +2 more
openaire +2 more sources
CD1d-expressing breast cancer cells modulate NKT cell-mediated antitumor immunity in a murine model of breast cancer metastasis. [PDF]
PLoS ONE, 2011 Tumor tolerance and immune suppression remain formidable obstacles to the efficacy of immunotherapies that harness the immune system to eradicate breast cancer.
Laura M Hix +5 more
doaj +1 more source
From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology
Immunological Reviews, Volume 339, Issue 1, May 2026.ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki +2 more
wiley +1 more source
Frontiers in Immunology, 2020 Following positive selection, NKT cell precursors enter an “NK-like” program and progress from an NK– to an NK+ maturational stage to give rise to NKT1 cells. Maturation takes place in the thymus or after emigration of NK– NKT cells to the periphery.
Jihene Klibi, Kamel Benlagha
doaj +1 more source
CD1d-dependent CLL progression? [PDF]
Blood, 2017 In this issue of Blood , Gorini et al provide compelling evidence for an indirect CD1d- and natural killer T (NKT) cell–dependent mechanism that promotes disease progression in chronic lymphocytic leukemia (CLL ...
openaire +2 more sources