Results 41 to 50 of about 20,572 (218)
PLoS ONE, 2010 BackgroundCD1d is a nonpolymorphic MHC class I-like molecule which presents nonpeptide ligands, e.g. glycolipids, to NKT cells. These cells are known to have multiple effects on innate and adaptive immune responses and on the development of pathological ...
Elisa Monzon-Casanova +11 more
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Crystal structures of bovine CD1d reveal altered αGalCer presentation and a restricted A' pocket unable to bind long-chain glycolipids. [PDF]
PLoS ONE, 2012 NKT cells play important roles in immune surveillance. They rapidly respond to pathogens by detecting microbial glycolipids when presented by the non-classical MHC I homolog CD1d. Previously, ruminants were considered to lack NKT cells due to the lack of
Jing Wang +5 more
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Galactosylsphingamides : new α-GalCer analogues to probe the F’-pocket of CD1d [PDF]
, 2017 Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic alpha-galactosylceramide, they produce a vast amount of cytokines.
Decruy, Tine +9 more
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A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis. [PDF]
PLoS ONE, 2016 BACKGROUND:Henoch-Schoenlein purpura is the one of most common types of systemic vasculitis that involves impaired renal function and Henoch-Schoenlein purpura nephritis (HSPN).
Xintong Hu +7 more
doaj +1 more source
CD1d and CD1d‐restricted iNKT‐cells play a pivotal role in contact hypersensitivity
Experimental Dermatology, 2005 Abstract: CD1d‐restricted T‐cells are activated by glycolipids presented by the major histocompatibility complex class‐Ib molecule CD1d, found on the surface of antigen‐presenting cells (APC). This interaction between APC, most notably dendritic cells (DC), and CD1d‐restricted T‐cells is an important regulatory step in the initiation of adaptive ...
Nieuwenhuis, Edward E S +9 more
openaire +5 more sources
Tailored design of NKT-stimulatory glycolipids for polarization of immune responses. [PDF]
, 2017 Natural killer T (NKT) cell is a distinct population of T lymphocytes that can rapidly release massive amount of Th1 and Th2 cytokines upon the engagement of their T cell receptor with glycolipids presented by CD1d.
Huang, Jing-Rong +2 more
core +2 more sources
CD1d-Restricted NKT Cells: An Interstrain Comparison [PDF]
The Journal of Immunology, 2001 AbstractCD1d-restricted Vα14-Jα281 invariant αβTCR+ (NKT) cells are well defined in the C57BL/6 mouse strain, but they remain poorly characterized in non-NK1.1-expressing strains. Surrogate markers for NKT cells such as αβTCR+CD4−CD8− and DX5+CD3+ have been used in many studies, although their effectiveness in defining this lineage remains to be ...
Hammond, Kirsten J. L. +6 more
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Invariant NKT cells and rheumatic disease: Focus on primary sjogren syndrome [PDF]
, 2019 Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology.
Barbera L. L. +5 more
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Species Specific Differences of CD1d Oligomer Loading In Vitro. [PDF]
PLoS ONE, 2015 CD1d molecules are MHC class I-like molecules that present glycolipids to iNKT cells. The highly conserved interaction between CD1d:α-Galactosylceramide (αGC) complexes and the iNKT TCR not only defines this population of αβ T cells but can also be used ...
Daniel Paletta +5 more
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Synthesis of C-5" and C-6"-modified α-GalCer analogues as iNKT-cell agonists [PDF]
, 2015 Alpha-Galactosyl Ceramide (α-GalCer) is a prototypical synthetic ligand of invariant natural killer T (iNKT) cells. Upon presentation by the MHC class I-like molecule CD1d, this glycolipid stimulates iNKT cells to secrete a vast amount of both pro ...
ASPESLAGH, SANDRINE +5 more
core +1 more source