Results 41 to 50 of about 13,147 (200)
PLoS ONE, 2010 BackgroundCD1d is a nonpolymorphic MHC class I-like molecule which presents nonpeptide ligands, e.g. glycolipids, to NKT cells. These cells are known to have multiple effects on innate and adaptive immune responses and on the development of pathological ...
Elisa Monzon-Casanova +11 more
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Crystal structures of bovine CD1d reveal altered αGalCer presentation and a restricted A' pocket unable to bind long-chain glycolipids. [PDF]
PLoS ONE, 2012 NKT cells play important roles in immune surveillance. They rapidly respond to pathogens by detecting microbial glycolipids when presented by the non-classical MHC I homolog CD1d. Previously, ruminants were considered to lack NKT cells due to the lack of
Jing Wang +5 more
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CD1d-lipid antigen recognition by the γδ TCR [PDF]
Nature Immunology, 2013 The T lymphocytes repertoire is divided into two major lineages, αβ and γδ T cells, which are defined by their T cell receptor (TCR) gene-segment usage. To date, the key discoveries on human CD1d restricted T cells have focussed on the type I Natural Killer T cells (NKT) subset that express an invariant TCR α chain (Vα24Jα18) which pairs with a β chain
Uldrich, AP +10 more
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A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis. [PDF]
PLoS ONE, 2016 BACKGROUND:Henoch-Schoenlein purpura is the one of most common types of systemic vasculitis that involves impaired renal function and Henoch-Schoenlein purpura nephritis (HSPN).
Xintong Hu +7 more
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Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop.
PLoS Biology, 2010 Invariant Natural Killer T cells (iNKT) are a versatile lymphocyte subset with important roles in both host defense and immunological tolerance. They express a highly conserved TCR which mediates recognition of the non-polymorphic, lipid-binding molecule
Gediminas Matulis +9 more
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Species Specific Differences of CD1d Oligomer Loading In Vitro. [PDF]
PLoS ONE, 2015 CD1d molecules are MHC class I-like molecules that present glycolipids to iNKT cells. The highly conserved interaction between CD1d:α-Galactosylceramide (αGC) complexes and the iNKT TCR not only defines this population of αβ T cells but can also be used ...
Daniel Paletta +5 more
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The molecular basis for recognition of CD1d/α-galactosylceramide by a human non-Vα24 T cell receptor. [PDF]
PLoS Biology, 2012 CD1d-mediated presentation of glycolipid antigens to T cells is capable of initiating powerful immune responses that can have a beneficial impact on many diseases.
Jacinto López-Sagaseta +4 more
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Frontiers in Immunology, 2015 Natural killer T (NKT) cells comprise a family of specialized T cells that recognize lipid antigens presented by CD1d. Based on their T cell receptor (TCR) usage and antigen-specificities, CD1d-restricted NKT cells have been divided into two main subsets:
Elodie eMacho-Fernandez, Manfred eBrigl
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Frontiers in Medicine, 2022 Invariant Natural Killer T (iNKT) cells are T lymphocytes expressing a conserved semi-invariant TCR specific for lipid antigens (Ags) restricted for the monomorphic MHC class I-related molecule CD1d.
Gloria Delfanti +4 more
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CD1d- and MR1-Restricted T Cells in Sepsis [PDF]
Frontiers in Immunology, 2015 Dysregulated immune responses to infection, such as those encountered in sepsis, can be catastrophic. Sepsis is typically triggered by an overwhelming systemic response to an infectious agent(s) and is associated with high morbidity and mortality even under optimal critical care. Recent studies have implicated unconventional, innate-like T lymphocytes,
Peter A. Szabo +6 more
openaire +3 more sources