Results 41 to 50 of about 14,498 (196)

The molecular basis for recognition of CD1d/α-galactosylceramide by a human non-Vα24 T cell receptor. [PDF]

PLoS Biology, 2012
CD1d-mediated presentation of glycolipid antigens to T cells is capable of initiating powerful immune responses that can have a beneficial impact on many diseases.
Jacinto López-Sagaseta, Jennifer E Kung, Paul B Savage, Jenny Gumperz, Erin J Adams   +4 more
doaj   +1 more source

Structure and binding kinetics of three different human CD1d-?-galactosylceramide-specific T cell receptors [PDF]

, 2006
Invariant human TCR V?24-J?18+/Vbeta11+ NKT cells (iNKT) are restricted by CD1d-?-glycosylceramides. We analyzed crystal structures and binding characteristics for an iNKT TCR plus two CD1d-?-GalCer-specific Vbeta11+ TCRs that use different TCR Valpha ...
Peter M. Villiger, E. Yvonne Jones, Gadola, Stephan D., Jones, E. Yvonne, Lissin, Nikolai M., Jon Marles-Wright, Jakobsen, Bent K., Cerundolo, Vincenzo, Stuart, David I., Marles-Wright, Jon, Matulis, Gediminas, Gediminas Matulis, Karl Harlos, Koch, Michael, Stuart, David I, Stephan D. Gadola, Harlos, Karl, David I. Stuart, Michael Koch, Jakobsen, Bent K, Vincenzo Cerundolo, Lissin, Nikolai M, Villiger, Peter M, Gadola, Stephan D, Jones, E Yvonne, Bent K. Jakobsen, Villiger, Peter M., Dawn Shepherd, Shepherd, Dawn, Nikolai M. Lissin, Stuart DI, Marles-Wright J, Koch M, Villiger, Peter, Cerundolo V, Harlos K, Matulis G, Lissin NM, Gadola SD, Villiger PM, Jones EY, Shepherd D, Jakobsen BK   +42 more
core   +1 more source

The extended family of CD1d-restricted T cells: sifting through a mixed bag of TCRs, antigens and functions

Frontiers in Immunology, 2015
Natural killer T (NKT) cells comprise a family of specialized T cells that recognize lipid antigens presented by CD1d. Based on their T cell receptor (TCR) usage and antigen-specificities, CD1d-restricted NKT cells have been divided into two main subsets:
Elodie eMacho-Fernandez, Manfred eBrigl
doaj   +1 more source

CD1d Endosomal Trafficking Is Independently Regulated by an Intrinsic CD1d-Encoded Tyrosine Motif and by the Invariant Chain [PDF]

Immunity, 2001
Endosomal trafficking is an essential component of the CD1 pathway of lipid antigen presentation to T cells. We demonstrate that CD1d access to endosomal compartments is under dual regulation by an intrinsic tyrosine-based motif, which governs intense recycling between the plasma membrane and the endosome, and by the invariant chain, with which CD1d ...
Jayawardena-Wolf, Jayanthi, Benlagha, Kamel, Chiu, Ya-Hui, Mehr, Ramit, Bendelac, Albert   +4 more
openaire   +2 more sources

Adoptive Immunotherapy With Engineered iNKT Cells to Target Cancer Cells and the Suppressive Microenvironment

Frontiers in Medicine, 2022
Invariant Natural Killer T (iNKT) cells are T lymphocytes expressing a conserved semi-invariant TCR specific for lipid antigens (Ags) restricted for the monomorphic MHC class I-related molecule CD1d.
Gloria Delfanti, Paolo Dellabona, Giulia Casorati, Maya Fedeli, Maya Fedeli   +4 more
doaj   +1 more source

iNKT Cells Suppress Pathogenic NK1.1+CD8+ T Cells in DSS-Induced Colitis

Frontiers in Immunology, 2018
T cells producing IFNγ play a pathogenic role in the development of inflammatory bowel disease (IBD). To investigate the functions of CD1d-dependent invariant natural killer T (iNKT) cells in experimental colitis induced in Yeti mice with dysregulated ...
Sung Won Lee, Hyun Jung Park, Jae Hee Cheon, Lan Wu, Luc Van Kaer, Seokmann Hong   +5 more
doaj   +1 more source

Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells. [PDF]

PLoS Biology, 2011
Invariant natural killer T (iNKT) cells are an evolutionary conserved T cell population characterized by features of both the innate and adaptive immune response.
Enrico Girardi, Esther Dawen Yu, Yali Li, Norihito Tarumoto, Bo Pei, Jing Wang, Petr Illarionov, Yuki Kinjo, Mitchell Kronenberg, Dirk M Zajonc   +9 more
doaj   +1 more source

Functionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining [PDF]

The Journal of Experimental Medicine, 2002
CD1d-restricted natural killer (NK)T cells are known to potently secrete T helper (Th)1 and Th2 cytokines and to mediate cytolysis, but it is unclear how these contrasting functional activities are regulated. Using lipid antigen–loaded CD1d tetramers, we have distinguished two subsets of CD1d-restricted T cells in fresh peripheral blood that differ in ...
Gumperz, Jenny E., Miyake, Sachiko, Yamamura, Takashi, Brenner, Michael B.   +3 more
openaire   +2 more sources

NKT cells are responsible for the clearance of murine norovirus through the virus-specific secretory IgA pathway

Biochemistry and Biophysics Reports, 2020
Norovirus infection cause epidemic nonbacterial gastroenteritis in patients. The immune mechanisms responsible for the clearance of virus are not completely understood. We examined whether NKT cells are effective against norovirus infection using CD1d KO
Hiroki Ishikawa, Satoshi Ino, Toshiko Yamochi, Hiraku Sasaki, Takahiro Kobayashi, Chikara Kohda, Masafumi Takimoto, Kazuo Tanaka   +7 more
doaj   +1 more source

Neurofibromin 1 Impairs Natural Killer T-Cell-Dependent Antitumor Immunity against a T-Cell Lymphoma

Frontiers in Immunology, 2018
Neurofibromin 1 (NF1) is a tumor suppressor gene encoding a Ras GTPase that negatively regulates Ras signaling pathways. Mutations in NF1 are linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome.
Jianyun Liu, Richard M. Gallo, Masood A. Khan, Masood A. Khan, Gourapura J. Renukaradhya, Gourapura J. Renukaradhya, Randy R. Brutkiewicz   +6 more
doaj   +1 more source