Results 41 to 50 of about 14,032 (192)
A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis. [PDF]
PLoS ONE, 2016 BACKGROUND:Henoch-Schoenlein purpura is the one of most common types of systemic vasculitis that involves impaired renal function and Henoch-Schoenlein purpura nephritis (HSPN).
Xintong Hu +7 more
doaj +1 more source
Polymorphisms in the CD1d Promoter That Regulate CD1d Gene Expression Are Associated with Impaired NKT Cell Development [PDF]
The Journal of Immunology, 2014 Abstract CD1d-restricted NKT cells comprise an innate-like T cell population that exerts significant influence over early events in the developing immune response. The frequency of NKT cells is highly variable in humans and in mice, but the basis for this variability remains unclear. In this study, we report a striking deficiency of type
Zachary D, Borg +7 more
openaire +2 more sources
Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop.
PLoS Biology, 2010 Invariant Natural Killer T cells (iNKT) are a versatile lymphocyte subset with important roles in both host defense and immunological tolerance. They express a highly conserved TCR which mediates recognition of the non-polymorphic, lipid-binding molecule
Gediminas Matulis +9 more
doaj +1 more source
Species Specific Differences of CD1d Oligomer Loading In Vitro. [PDF]
PLoS ONE, 2015 CD1d molecules are MHC class I-like molecules that present glycolipids to iNKT cells. The highly conserved interaction between CD1d:α-Galactosylceramide (αGC) complexes and the iNKT TCR not only defines this population of αβ T cells but can also be used ...
Daniel Paletta +5 more
doaj +1 more source
The molecular basis for recognition of CD1d/α-galactosylceramide by a human non-Vα24 T cell receptor. [PDF]
PLoS Biology, 2012 CD1d-mediated presentation of glycolipid antigens to T cells is capable of initiating powerful immune responses that can have a beneficial impact on many diseases.
Jacinto López-Sagaseta +4 more
doaj +1 more source
CD1d-lipid antigen recognition by the γδ TCR [PDF]
Nature Immunology, 2013 The T lymphocytes repertoire is divided into two major lineages, αβ and γδ T cells, which are defined by their T cell receptor (TCR) gene-segment usage. To date, the key discoveries on human CD1d restricted T cells have focussed on the type I Natural Killer T cells (NKT) subset that express an invariant TCR α chain (Vα24Jα18) which pairs with a β chain
Uldrich, AP +10 more
openaire +3 more sources
Human CD1D Gene Expression Is Regulated by LEF-1 through Distal Promoter Regulatory Elements [PDF]
, 2010 CD1d-expressing cells present lipid Ag to CD1d-restricted NKT cells, which play an important role in immune regulation and tumor rejection. Lymphoid enhancer-binding factor-1 (LEF-1) is one of the regulators of the Wnt signaling pathway, which is a ...
Chen, Qiao-Yi +8 more
core +1 more source
Frontiers in Immunology, 2015 Natural killer T (NKT) cells comprise a family of specialized T cells that recognize lipid antigens presented by CD1d. Based on their T cell receptor (TCR) usage and antigen-specificities, CD1d-restricted NKT cells have been divided into two main subsets:
Elodie eMacho-Fernandez, Manfred eBrigl
doaj +1 more source
iNKT Cells Suppress Pathogenic NK1.1+CD8+ T Cells in DSS-Induced Colitis
Frontiers in Immunology, 2018 T cells producing IFNγ play a pathogenic role in the development of inflammatory bowel disease (IBD). To investigate the functions of CD1d-dependent invariant natural killer T (iNKT) cells in experimental colitis induced in Yeti mice with dysregulated ...
Sung Won Lee +5 more
doaj +1 more source
Frontiers in Medicine, 2022 Invariant Natural Killer T (iNKT) cells are T lymphocytes expressing a conserved semi-invariant TCR specific for lipid antigens (Ags) restricted for the monomorphic MHC class I-related molecule CD1d.
Gloria Delfanti +4 more
doaj +1 more source