Results 21 to 30 of about 14,032 (192)
Emerging Microbes and Infections, 2023 African swine fever (ASF) is a highly contagious and acute hemorrhagic viral disease with high morbidity and mortality in domestic pigs and wild boars. The disease has become a global threat to the pig production industry and has caused enormous economic
Xin Chen +11 more
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Frontiers in Cell and Developmental Biology, 2022 Nonalcoholic fatty liver disease (NAFLD) is a class of metabolic-associated liver diseases. Aberrant lipid consumption plays an important role in NAFLD pathogenesis.
Qiuxian Zheng +7 more
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CD1d-dependent rewiring of lipid metabolism in macrophages regulates innate immune responses.
, 2022 Alterations in cellular metabolism underpin macrophage activation, yet little is known regarding how key immunological molecules regulate metabolic programs in macrophages.
Phillip M Brailey (9568493) +9 more
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Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells [PDF]
Proceedings of the National Academy of Sciences, 2009 CD1 proteins constitute a distinct lineage of antigen-presenting molecules specialized for the presentation of lipid antigens to T cells. In contrast to the extensive sequence polymorphism characteristic of classical MHC molecules, CD1 proteins exhibit limited sequence diversity.
Michael I, Zimmer +9 more
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BMC Gastroenterology, 2022 Introduction Glucocorticoids contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Natural killer T cells play a role in the pathogenesis of NAFLD and response to steroids.
Tomer Adar +6 more
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CD1d-restricted iNKT cells contribute to protection against GBS infection in vivo.
, 2023 (A) Schematic created using BioRender.com displaying the experimental design. WT, CD1d-/-, and Traj18-/- mice were immunized with R-P4 and boosted 14 days later. At day 21, mice were challenged with HH GBS (WT NCTC10/84).
Shayla Nguyen (16469978) +15 more
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Forming a complex with MHC class I molecules interferes with mouse CD1d functional expression. [PDF]
PLoS ONE, 2013 CD1d molecules are structurally similar to MHC class I, but present lipid antigens as opposed to peptides. Here, we show that MHC class I molecules physically associate with (and regulate the functional expression of) mouse CD1d on the surface of cells ...
Renukaradhya J Gourapura +5 more
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Haematologica, 2009 Background CD1d is a monomorphic antigen presentation molecule expressed in several hematologic malignancies. Alpha-galactosylceramide (α-GalCer) is a glycolipid that can be presented to cytotoxic CD1d-restricted T cells.
Davide Bagnara +12 more
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Frontiers in Immunology, 2019 iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with similar structures induces robust proliferation and cytokine production of iNKT cells and ...
Katharine Clark +14 more
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CD1d presentation of glycolipids
Immunology & Cell Biology, 2008 The CD1 family of antigen‐presenting molecules consists of five members, CD1a to e. Of these molecules CD1d has been the subject of much interest over the past 10 years following the discovery that this molecule presents antigens to a group of T cells known as invariant natural killer T cells (iNKT).
Speak, A, Cerundolo, V, Platt, F
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