PLoS ONE, 2010 BackgroundCD1d is a nonpolymorphic MHC class I-like molecule which presents nonpeptide ligands, e.g. glycolipids, to NKT cells. These cells are known to have multiple effects on innate and adaptive immune responses and on the development of pathological ...
Elisa Monzon-Casanova +11 more
doaj +1 more source
CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides
Frontiers in Immunology, 2018 NKT cells belong to a distinct subset of T cells that recognize hydrophobic antigens presented by major histocompatibility complex class I-like molecules, such as CD1d.
Yusuke Nishioka +3 more
doaj +1 more source
A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis. [PDF]
PLoS ONE, 2016 BACKGROUND:Henoch-Schoenlein purpura is the one of most common types of systemic vasculitis that involves impaired renal function and Henoch-Schoenlein purpura nephritis (HSPN).
Xintong Hu +7 more
doaj +1 more source
Overexpression of CD1d by Keratinocytes in Psoriasis and CD1d-Dependent IFN-γ Production by NK-T Cells [PDF]
The Journal of Immunology, 2000 Abstract The MHC class I-like protein CD1d is a nonpolymorphic molecule that plays a central role in development and activation of a subset of T cells that coexpress receptors used by NK cells (NK-T cells). Recently, T cells bearing NK receptors were identified in acute and chronic lesions of psoriasis. To determine whether NK-T cells
B, Bonish +7 more
openaire +2 more sources
Endoplasmic Reticulum Glycoprotein Quality Control Regulates CD1d Assembly and CD1d-mediated Antigen Presentation [PDF]
Journal of Biological Chemistry, 2013 The non-classical major histocompatibility complex (MHC) homologue CD1d presents lipid antigens to innate-like lymphocytes called natural-killer T (NKT) cells. These cells, by virtue of their broad cytokine repertoire, shape innate and adaptive immune responses.
Kunte, Amit +6 more
openaire +2 more sources
Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop.
PLoS Biology, 2010 Invariant Natural Killer T cells (iNKT) are a versatile lymphocyte subset with important roles in both host defense and immunological tolerance. They express a highly conserved TCR which mediates recognition of the non-polymorphic, lipid-binding molecule
Gediminas Matulis +9 more
doaj +1 more source
Species Specific Differences of CD1d Oligomer Loading In Vitro. [PDF]
PLoS ONE, 2015 CD1d molecules are MHC class I-like molecules that present glycolipids to iNKT cells. The highly conserved interaction between CD1d:α-Galactosylceramide (αGC) complexes and the iNKT TCR not only defines this population of αβ T cells but can also be used ...
Daniel Paletta +5 more
doaj +1 more source
Cardiolipin Binds to CD1d and Stimulates CD1d-Restricted γδ T Cells in the Normal Murine Repertoire [PDF]
The Journal of Immunology, 2011 Abstract Cardiolipin (CL), a major phospholipid in bacterial cell walls, is sequestered from the immune system in mammalian mitochondria and is, therefore, a potential danger signal. Based on growing evidence that phospholipids constitute natural ligands for CD1 and that CD1d-restricted T cells recognize phospholipids, we hypothesized ...
Mélanie, Dieudé +8 more
openaire +2 more sources
Polymorphisms in the CD1d Promoter That Regulate CD1d Gene Expression Are Associated with Impaired NKT Cell Development [PDF]
The Journal of Immunology, 2014 Abstract CD1d-restricted NKT cells comprise an innate-like T cell population that exerts significant influence over early events in the developing immune response. The frequency of NKT cells is highly variable in humans and in mice, but the basis for this variability remains unclear. In this study, we report a striking deficiency of type
Zachary D, Borg +7 more
openaire +2 more sources
The molecular basis for recognition of CD1d/α-galactosylceramide by a human non-Vα24 T cell receptor. [PDF]
PLoS Biology, 2012 CD1d-mediated presentation of glycolipid antigens to T cells is capable of initiating powerful immune responses that can have a beneficial impact on many diseases.
Jacinto López-Sagaseta +4 more
doaj +1 more source