Results 11 to 20 of about 14,498 (196)

Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells [PDF]

The Journal of Immunology, 2004
A subset of CD161+CD56+/- NKT cells can recognize glycolipids presented by CD1d and positively or negatively regulate inflammatory responses, including those implicated in several models of hepatitis.
Nasser, Imad, Exley, Mark A., Koziel, Margaret J., Shaulov, Angela, He, Qi, Wang, RuoJie, Afdhal, Nezam, Durante-Mangoni, Emanuele   +7 more
core   +13 more sources

Role of CD1d in Coxsackievirus B3-induced myocarditis [PDF]

The Journal of Immunology, 2003
The myocarditic (H3) variant of Coxsackievirus B3 (CVB3) causes severe myocarditis in BALB/c mice and BALB/c mice lacking the invariant Jα281 gene, but minimal disease in BALB/c CD1d-/- animals.
Sartini, Danielle, Exley, Mark, Huber, Sally   +2 more
core   +10 more sources

Impact of CD1d deficiency on metabolism. [PDF]

PLoS ONE, 2011
Invariant natural killer T cells (iNKTs) are innate-like T cells that are highly concentrated in the liver and recognize lipids presented on the MHC-like molecule CD1d.
Maya E Kotas, Hui-Young Lee, Matthew P Gillum, Charles Annicelli, Blas A Guigni, Gerald I Shulman, Ruslan Medzhitov   +6 more
doaj   +4 more sources

Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells.

The Journal of Immunology, 1999
NKT cells, defined as T cells expressing the NK cell marker NK1.1, are involved in tumor rejection and regulation of autoimmunity via the production of cytokines.
Taniguchi, M., Eberl, G., Smiley, S.T., Grusby, M.J., Lees, R., MacDonald, H.R.   +5 more
core   +8 more sources

CD1d activation and blockade: A new antitumor strategy [PDF]

The Journal of Immunology, 2009
CD1d is expressed on APCs and presents glycolipids to CD1d-restricted NKT cells. For the first time, we demonstrate the ability of anti-CD1d mAbs to inhibit the growth of different CD1d-negative experimental carcinomas in mice.
Sharkey, Janelle, Teng, Michele W L, Exley, Mark A., Teng, Michele W. L., Smyth, Mark J., Yue, Simon   +5 more
core   +5 more sources

Structure-Function Implications of the Ability of Monoclonal Antibodies Against α-Galactosylceramide-CD1d Complex to Recognize β-Mannosylceramide Presentation by CD1d

Frontiers in Immunology, 2019
iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with similar structures induces robust proliferation and cytokine production of iNKT cells and ...
Katharine Clark, Jessica Yau, Anja Bloom, Jing Wang, David J. Venzon, Motoshi Suzuki, Lise Pasquet, Benjamin J. Compton, Susanna L. Cardell, Steven A. Porcelli, Gavin F. Painter, Dirk M. Zajonc, Dirk M. Zajonc, Jay A. Berzofsky, Masaki Terabe   +14 more
doaj   +2 more sources

Adoptive immunotherapy mediated by ex vivo expanded natural killer T cells against CD1d-expressing lymphoid neoplasms [PDF]

Haematologica, 2009
Background CD1d is a monomorphic antigen presentation molecule expressed in several hematologic malignancies. Alpha-galactosylceramide (α-GalCer) is a glycolipid that can be presented to cytotoxic CD1d-restricted T cells.
Davide Bagnara, Adalberto Ibatici, Mirko Corselli, Nadia Sessarego, Claudya Tenca, Amleto De Santanna, Andrea Mazzarello, Antonio Daga, Renzo Corvò, Giulio De Rossi, Francesco Frassoni, Ermanno Ciccone, Franco Fais   +12 more
doaj   +2 more sources

Cardiolipin Binds to CD1d and Stimulates CD1d-Restricted γδ T Cells in the Normal Murine Repertoire [PDF]

The Journal of Immunology, 2011
Cardiolipin (CL), a major phospholipid in bacterial cell walls, is sequestered from the immune system in mammalian mitochondria and is, therefore, a potential danger signal.
Joyce Rauch, Ciriaco A. Piccirillo, Harald Striegl, Aaron J. Tyznik, Dirk M. Zajonc, Jing Wang, Samuel M. Behar, Jerrold S. Levine, Mélanie Dieudé   +8 more
core   +3 more sources

Analysis of the Role of N-Linked Glycans on Human CD1d Molecules. [PDF]

Cell Biochem Funct
ABSTRACT CD1d is a cell‐surface expressed glycoprotein that presents a variety of lipid and glycolipid antigens to invariant natural killer T‐cells (iNKT). We have examined the role of the N‐linked glycans on the human CD1d (hCD1d) in modulating the responses of iNKT cells using a combination of cell‐free, cell‐based assays and in silico analyses ...
Bandyopadhyay S, Pradhan S.
europepmc   +2 more sources

Identifying Co-Expressed lncRNAs Correlated With Traits of Interest in an Animal Model for Metabolic Diseases in Humans. [PDF]

Anim Genet
ABSTRACT Nutrigenomics investigates how nutrients modulate gene expression. Among them, fatty acids (FA) play important roles in regulating gene transcription, while long non‐coding RNAs (lncRNAs) may be associated with gene regulation and metabolic diseases.
Nascimento LE, da Silva BPM, de Oliveira CS, Durval MC, Freitas FAO, Ciconello FN, Gervásio IC, Fanalli SL, de Souza Fonseca PA, Gutiérrez-Gil B, de Almeida VV, Cesar ASM.   +11 more
europepmc   +2 more sources