Results 11 to 20 of about 14,032 (192)

Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions [PDF]

Journal for ImmunoTherapy of Cancer, 2023
Background CD1d is a monomorphic major histocompatibility complex class I-like molecule that presents lipid antigens to distinct T-cell subsets and can be expressed by various malignancies.
Tanja D de Gruijl, Roeland Lameris, Jamie Rossjohn, Myrthe Veth, David Lutje Hulsik, Adam Shahine, Bart Westerman, Dale I Godfrey, Patricia Brouwer, Hans J van der Vliet   +9 more
doaj   +3 more sources

Impact of CD1d deficiency on metabolism. [PDF]

PLoS ONE, 2011
Invariant natural killer T cells (iNKTs) are innate-like T cells that are highly concentrated in the liver and recognize lipids presented on the MHC-like molecule CD1d.
Maya E Kotas, Hui-Young Lee, Matthew P Gillum, Charles Annicelli, Blas A Guigni, Gerald I Shulman, Ruslan Medzhitov   +6 more
doaj   +4 more sources

Endoplasmic Reticulum Glycoprotein Quality Control Regulates CD1d Assembly and CD1d-mediated Antigen Presentation [PDF]

Journal of Biological Chemistry, 2013
The non-classical major histocompatibility complex (MHC) homologue CD1d presents lipid antigens to innate-like lymphocytes called natural-killer T (NKT) cells.
Liam R. Cox, Wei Zhang, Cresswell, Peter, Zhang, Wei, Amit Kunte, Natacha Veerapen, Veerapen, Natacha, Crina Paduraru, Peter Cresswell, Kunte, Amit, Besra, Gurdyal S; id_orcid, Gurdyal S. Besra, Cox, Liam R; id_orcid, Paduraru, Crina   +13 more
core   +3 more sources

Cardiolipin Binds to CD1d and Stimulates CD1d-Restricted γδ T Cells in the Normal Murine Repertoire [PDF]

The Journal of Immunology, 2011
Cardiolipin (CL), a major phospholipid in bacterial cell walls, is sequestered from the immune system in mammalian mitochondria and is, therefore, a potential danger signal.
Joyce Rauch, Ciriaco A. Piccirillo, Harald Striegl, Aaron J. Tyznik, Dirk M. Zajonc, Jing Wang, Samuel M. Behar, Jerrold S. Levine, Mélanie Dieudé   +8 more
core   +3 more sources

Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells.

The Journal of Immunology, 1999
NKT cells, defined as T cells expressing the NK cell marker NK1.1, are involved in tumor rejection and regulation of autoimmunity via the production of cytokines.
Taniguchi, M., Eberl, G., Smiley, S.T., Grusby, M.J., Lees, R., MacDonald, H.R.   +5 more
core   +4 more sources

Role of CD1d in Coxsackievirus B3-induced myocarditis [PDF]

The Journal of Immunology, 2003
The myocarditic (H3) variant of Coxsackievirus B3 (CVB3) causes severe myocarditis in BALB/c mice and BALB/c mice lacking the invariant Jα281 gene, but minimal disease in BALB/c CD1d-/- animals.
Sartini, Danielle, Exley, Mark, Huber, Sally   +2 more
core   +9 more sources

TGFβ Inhibits CD1d Expression on Dendritic Cells [PDF]

Journal of Investigative Dermatology, 2005
The CD1 family of cell surface glycoprotein has been demonstrated to be a third lineage of antigen-presenting molecules for specific T cell responses. They present lipidic, glycolipidic antigen and hydrophobic peptide to T cells.
Ronger-Savle, S., Jullien, D., Schmitt, D., Peguet-Navarro, J., Thomas, L., Claudy, A., Dezutter-Dambuyant, C., Valladeau, J.   +7 more
core   +4 more sources

CD1d activation and blockade: A new antitumor strategy [PDF]

The Journal of Immunology, 2009
CD1d is expressed on APCs and presents glycolipids to CD1d-restricted NKT cells. For the first time, we demonstrate the ability of anti-CD1d mAbs to inhibit the growth of different CD1d-negative experimental carcinomas in mice.
Sharkey, Janelle, Teng, Michele W L, Exley, Mark A., Teng, Michele W. L., Smyth, Mark J., Yue, Simon   +5 more
core   +5 more sources

Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells

, 2004
A subset of CD161+CD56+/- NKT cells can recognize glycolipids presented by CD1d and positively or negatively regulate inflammatory responses, including those implicated in several models of hepatitis.
Nasser, Imad, Exley, Mark A., Koziel, Margaret J., Shaulov, Angela, He, Qi, Wang, RuoJie, Afdhal, Nezam, Durante-Mangoni, Emanuele   +7 more
core   +13 more sources

The Immutable Recognition of CD1d [PDF]

Immunity, 2011
CD1d presents lipid antigens to natural killer T cells. In this issue of Immunity, Wun et al. (2011) and Mallevaey et al. (2011) explore the molecular details of nonself lipid discrimination and self-recognition.
Adams, Erin J., López-Sagaseta, Jacinto   +1 more
openaire   +2 more sources