Results 11 to 20 of about 20,572 (218)

Sortase A-Cleavable CD1d Identifies Sphingomyelins as Major Class of CD1d-Associated Lipids

Frontiers in Immunology, 2022
CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids and can activate natural killer T (NKT) cells through the presentation of lipid antigens. CD1d surveys different cellular compartments including the secretory and the endolysosomal pathway and broadly binds lipids through its two hydrophobic pockets.
Maren Rudolph, Maren Rudolph, Yuting Wang, Yuting Wang, Yuting Wang, Theresa Simolka, Theresa Simolka, Emilie Huc-Claustre, Emilie Huc-Claustre, Lingyun Dai, Gijsbert Grotenbreg, Gurdyal Singh Besra, Anna Shevchenko, Andrej Shevchenko, Sebastian Zeissig, Sebastian Zeissig   +15 more
openaire   +5 more sources

Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions

Journal for ImmunoTherapy of Cancer, 2023
Background CD1d is a monomorphic major histocompatibility complex class I-like molecule that presents lipid antigens to distinct T-cell subsets and can be expressed by various malignancies. Antibody-mediated targeting of CD1d on multiple myeloma cells was reported to induce apoptosis and could therefore constitute a
Roeland Lameris, Adam Shahine, Myrthe Veth, Bart Westerman, Dale I Godfrey, David Lutje Hulsik, Patricia Brouwer, Jamie Rossjohn, Tanja D de Gruijl, Hans J van der Vliet   +9 more
openaire   +6 more sources

Zerumbone mediated CD1d inhibition suppresses epithelial to mesenchymal transition in triple negative breast cancer [PDF]

Discover Oncology
Triple-negative breast cancer (TNBC) is characterized by aggressive metastatic behavior driven through epithelial-to-mesenchymal transition (EMT). CD1d, a non-classical MHC molecule, modulates immune responses via Natural Killer T (NKT) cells and is ...
Ritis Kumar Shyanti, Sudhanshu Sharma, Mazharul Haque, Rajan Kumar Tiwari, Rajesh Singh, Manoj Mishra   +5 more
doaj   +2 more sources

γδ T cell receptor recognition of CD1d in a lipid-independent manner [PDF]

Nature Communications
The monomorphic antigen-presenting molecule CD1d presents lipid antigens to both αβ and γδ T cells. While type I natural killer T cells (NKT) display exquisite specificity for CD1d presenting α-galactosylceramide (α-GalCer), the extent of lipid ...
Michael T. Rice, Sachith D. Gunasinghe, Chhon Ling Sok, Mengqi Pan, Chan-Sien Lay, Benjamin S. Gully, Jamie Rossjohn   +6 more
doaj   +2 more sources

Impact of CD1d Deficiency on Metabolism [PDF]

PLoS ONE, 2011
Invariant natural killer T cells (iNKTs) are innate-like T cells that are highly concentrated in the liver and recognize lipids presented on the MHC-like molecule CD1d. Although capable of a myriad of responses, few essential functions have been described for iNKTs.
Maya E Kotas, Hui-Young Lee, Matthew P Gillum, Charles Annicelli, Blas A Guigni, Gerald I Shulman, Ruslan Medzhitov   +6 more
openaire   +4 more sources

Upregulation of CD1d and ULBP3 on B cells from healthy donors and chronic lymphocytic leukaemia patients does not prime them for killing by γδ T cells. [PDF]

PLoS ONE
Despite advances in treatment, chronic lymphocytic leukaemia (CLL) remains an incurable disease. Vδ1+ γδ T cells are reported to expand in CLL patients and to kill leukemic cells, placing them as candidates for immunotherapy.
Julie David, Amy Walsh, Ke Sin Seow, Ellen Walsh, Stefan Elekes, Rohit Upadhyay, Nawal A B Taher, Samiha Al Siyabi, Ashanty M Melo, Carmel Waldron, Elisabeth Vandenberghe, Anthony M McElligott, Derek G Doherty   +12 more
doaj   +2 more sources

iNKT Cells and Their potential Lipid Ligands during Viral Infection [PDF]

Frontiers in Immunology, 2015
Invariant natural killer T (iNKT) cells are a unique population of lipid reactive CD1d restricted innate-like T lymphocytes. Despite being a minor population, they serve as an early source of cytokines and promote immunological crosstalk thus bridging ...
Anunya eOpasawatchai, Anunya eOpasawatchai, Ponpan eMatangkasombut, Ponpan eMatangkasombut   +3 more
doaj   +2 more sources

HSV-1 UL56 protein recruits cellular NEDD4-family ubiquitin ligases to suppress CD1d expression and NKT cell function [PDF]

Journal of Virology
Herpesviruses, including α-herpesvirus and herpes simplex virus (HSV-1), are masters of immune evasion. Previously we demonstrated that CD1d-restricted NKT cells are required for optimal anti-HSV-1 immune responses and HSV-1 efficiently downregulates ...
Lingxi Qiu, Xuedi Gao, Xinyue Shao, Jingwen Xi, Siyang Chen, Thanh Pham, Yi Wang, Jonathan Dong, Samhita Divakar Rao, Jingting Hao, Jae Ho Lo, Rirong Yang, Esteban A. Engel, Colin M. Crump, Weiming Yuan   +14 more
doaj   +2 more sources

ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids [PDF]

, 2020
CD1d-restricted invariant natural killer T (iNKT) cells constitute a common glycolipid-reactive innate-like T-cell subset with a broad impact on innate and adaptive immunity.
Cheng, Tan‐Yun, Cloots, Eva, De Geest, Bruno, Drennan, Michael, Elewaut, Dirk, Gaublomme, Djoere, Govindarajan, Srinath, Gysens, Fien, Janssens, Sophie, Maelegheer, Margaux, Moody, D Branch, Venken, Koen, Verheugen, Eveline   +12 more
core   +2 more sources

The Immutable Recognition of CD1d [PDF]

Immunity, 2011
CD1d presents lipid antigens to natural killer T cells. In this issue of Immunity, Wun et al. (2011) and Mallevaey et al. (2011) explore the molecular details of nonself lipid discrimination and self-recognition.
Adams, Erin J., López-Sagaseta, Jacinto   +1 more
openaire   +2 more sources