Results 11 to 20 of about 10,329 (179)
Impact of CD1d deficiency on metabolism. [PDF]
PLoS ONE, 2011 Invariant natural killer T cells (iNKTs) are innate-like T cells that are highly concentrated in the liver and recognize lipids presented on the MHC-like molecule CD1d.
Maya E Kotas +6 more
doaj +4 more sources
The Immutable Recognition of CD1d [PDF]
Immunity, 2011 CD1d presents lipid antigens to natural killer T cells. In this issue of Immunity, Wun et al. (2011) and Mallevaey et al. (2011) explore the molecular details of nonself lipid discrimination and self-recognition.
Adams, Erin J. +1 more
openaire +2 more sources
Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells [PDF]
Proceedings of the National Academy of Sciences, 2009 CD1 proteins constitute a distinct lineage of antigen-presenting molecules specialized for the presentation of lipid antigens to T cells. In contrast to the extensive sequence polymorphism characteristic of classical MHC molecules, CD1 proteins exhibit limited sequence diversity.
Michael I, Zimmer +9 more
openaire +2 more sources
Forming a complex with MHC class I molecules interferes with mouse CD1d functional expression. [PDF]
PLoS ONE, 2013 CD1d molecules are structurally similar to MHC class I, but present lipid antigens as opposed to peptides. Here, we show that MHC class I molecules physically associate with (and regulate the functional expression of) mouse CD1d on the surface of cells ...
Renukaradhya J Gourapura +5 more
doaj +1 more source
Haematologica, 2009 Background CD1d is a monomorphic antigen presentation molecule expressed in several hematologic malignancies. Alpha-galactosylceramide (α-GalCer) is a glycolipid that can be presented to cytotoxic CD1d-restricted T cells.
Davide Bagnara +12 more
doaj +1 more source
Frontiers in Immunology, 2019 iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with similar structures induces robust proliferation and cytokine production of iNKT cells and ...
Katharine Clark +14 more
doaj +1 more source
CD1d presentation of glycolipids
Immunology & Cell Biology, 2008 The CD1 family of antigen‐presenting molecules consists of five members, CD1a to e. Of these molecules CD1d has been the subject of much interest over the past 10 years following the discovery that this molecule presents antigens to a group of T cells known as invariant natural killer T cells (iNKT).
Speak, A, Cerundolo, V, Platt, F
openaire +2 more sources
OncoImmunology, 2018 Immunotherapies that target CD1d-restricted invariant NKT (iNKT) cells can prevent tumor growth in murine models but trials in humans have shown limited clinical efficacy. Here, we show that iNKT cells are depleted from blood and bronchial lavage samples
Éilis Dockry +6 more
doaj +1 more source
Come forth CD1d: Hsp110 in the regulation of intestinal epithelial CD1d expression [PDF]
Journal of Clinical Investigation, 2003 CD1d, a nonclassical MHC class I-like molecule, is prominently expressed on intestinal epithelial cells and is thought to function in the regulation of intestinal intraepithelial lymphocyte activity. Hsp110, an abundant heat shock protein present in essentially all mammalian tissues, has now been shown to upregulate CD1d expression in colonic tissue ...
openaire +2 more sources
Crystal structures of bovine CD1d reveal altered αGalCer presentation and a restricted A' pocket unable to bind long-chain glycolipids. [PDF]
PLoS ONE, 2012 NKT cells play important roles in immune surveillance. They rapidly respond to pathogens by detecting microbial glycolipids when presented by the non-classical MHC I homolog CD1d. Previously, ruminants were considered to lack NKT cells due to the lack of
Jing Wang +5 more
doaj +1 more source