Impact of CD1d deficiency on metabolism. [PDF]
PLoS ONE, 2011 Invariant natural killer T cells (iNKTs) are innate-like T cells that are highly concentrated in the liver and recognize lipids presented on the MHC-like molecule CD1d.
Maya E Kotas +6 more
doaj +5 more sources
Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex
Virology, 2005 The HIV-1 Nef protein causes a decrease in major histocompatibility complex (MHC) class I and CD4 molecule expression on the cell surface. To determine if Nef can affect components of the innate immune response, we assessed the ability of Nef to alter ...
Kenneth S Knox +2 more
exaly +4 more sources
Endoplasmic Reticulum Glycoprotein Quality Control Regulates CD1d Assembly and CD1d-mediated Antigen Presentation [PDF]
Journal of Biological Chemistry, 2013 The non-classical major histocompatibility complex (MHC) homologue CD1d presents lipid antigens to innate-like lymphocytes called natural-killer T (NKT) cells.
Liam R. Cox +13 more
core +3 more sources
Cardiolipin Binds to CD1d and Stimulates CD1d-Restricted γδ T Cells in the Normal Murine Repertoire [PDF]
The Journal of Immunology, 2011 Cardiolipin (CL), a major phospholipid in bacterial cell walls, is sequestered from the immune system in mammalian mitochondria and is, therefore, a potential danger signal.
Joyce Rauch +8 more
core +3 more sources
Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells [PDF]
The Journal of Immunology, 2004 A subset of CD161+CD56+/- NKT cells can recognize glycolipids presented by CD1d and positively or negatively regulate inflammatory responses, including those implicated in several models of hepatitis.
Nasser, Imad +7 more
core +9 more sources
Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells.
The Journal of Immunology, 1999 NKT cells, defined as T cells expressing the NK cell marker NK1.1, are involved in tumor rejection and regulation of autoimmunity via the production of cytokines.
Taniguchi, M. +5 more
core +4 more sources
TGFβ Inhibits CD1d Expression on Dendritic Cells [PDF]
Journal of Investigative Dermatology, 2005 The CD1 family of cell surface glycoprotein has been demonstrated to be a third lineage of antigen-presenting molecules for specific T cell responses. They present lipidic, glycolipidic antigen and hydrophobic peptide to T cells.
Ronger-Savle, S. +7 more
core +3 more sources
CD1d Endosomal Trafficking Is Independently Regulated by an Intrinsic CD1d-Encoded Tyrosine Motif and by the Invariant Chain [PDF]
Immunity, 2001 Endosomal trafficking is an essential component of the CD1 pathway of lipid antigen presentation to T cells. We demonstrate that CD1d access to endosomal compartments is under dual regulation by an intrinsic tyrosine-based motif, which governs intense ...
Jayawardena-Wolf, Jayanthi +9 more
core +3 more sources
CD1d activation and blockade: A new antitumor strategy [PDF]
The Journal of Immunology, 2009 CD1d is expressed on APCs and presents glycolipids to CD1d-restricted NKT cells. For the first time, we demonstrate the ability of anti-CD1d mAbs to inhibit the growth of different CD1d-negative experimental carcinomas in mice.
Sharkey, Janelle +5 more
core +5 more sources
Role of CD1d in Coxsackievirus B3-induced myocarditis [PDF]
The Journal of Immunology, 2003 The myocarditic (H3) variant of Coxsackievirus B3 (CVB3) causes severe myocarditis in BALB/c mice and BALB/c mice lacking the invariant Jα281 gene, but minimal disease in BALB/c CD1d-/- animals.
Sartini, Danielle +2 more
core +6 more sources