Results 51 to 60 of about 75,921 (210)
Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis [PDF]
, 2017 Chronic lymphocytic leukemia (CLL) is characterized by the expansion of malignant CD5(+) B lymphocytes in blood, bone marrow and lymphoid organs. CD1d-restricted invariant Natural Killer T (iNKT) cells are innate-like T lymphocytes strongly implicated in
Azzimonti, Laura +17 more
core +1 more source
BMC Cancer, 2018 Background Salivary gland cancers are not sensitive to conventional radiotherapy or chemotherapy regimens. Therefore, the development of a new treatment strategy is of critical importance for improving the prognosis.
Yuji Makita +7 more
doaj +1 more source
Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections
Frontiers in Immunology, 2018 The immune system has been traditionally divided into two arms called innate and adaptive immunity. Typically, innate immunity refers to rapid defense mechanisms that set in motion within minutes to hours following an insult.
François Trottein +6 more
doaj +1 more source
An optimized method for isolating and expanding invariant natural killer T cells from mouse spleen [PDF]
, 2015 The ability to rapidly secrete cytokines upon stimulation is a functional characteristic of the invariant natural killer T (iNKT) cell lineage. iNKT cells are therefore characterized as an innate T cell population capable of activating and steering ...
Drennan, Michael +2 more
core +1 more source
Activation mechanisms of invariant natural killer T cells (iNKTs)
Iatreia, 2016 A great amount of knowledge on natural killer T cells (iNKTs) is now available, but a consensus about their activation mechanisms has not been reached. These cells recognize different glycolipid antigens through the CD1d molecule.
Baena, Andrés +2 more
doaj +1 more source
Homeostatic regulation of marginal zone B cells by invariant natural killer T cells. [PDF]
PLoS ONE, 2011 Marginal zone B cells (MZB) mount a rapid antibody response, potently activate naïve T cells, and are enriched in autoreactive B cells. MZBs express high levels of CD1d, the restriction element for invariant natural killer T cells (iNKT).
Xiangshu Wen +3 more
doaj +1 more source
Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells
Nature Communications, 2020 Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental ...
S. Harsha Krovi +6 more
doaj +1 more source
Development and Function of Invariant Natural Killer T Cells Producing TH2- and TH17-Cytokines
PLoS Biology, 2012 Four distinct subsets of invariant natural killer T (NKT) cells are shown to differentiate in the thymus, then migrate to peripheral tissues where they retain their phenotypic and functional characteristics.
H. Watarai +10 more
semanticscholar +1 more source
Unraveling Natural Killer T-Cells Development
Frontiers in Immunology, 2018 Natural killer T-cells are a subset of innate-like T-cells with the ability to bridge innate and adaptive immunity. There is great interest in harnessing these cells to improve tumor therapy; however, greater understanding of invariant NKT (iNKT) cell ...
Sabrina Bianca Bennstein
doaj +1 more source
Natural killer T cell and pathophysiology of asthma [PDF]
Korean Journal of Pediatrics, 2010 Natural killer T (NKT) cell is a special type of T lymphocytes that has both receptor of natural killer (NK) cell (NK1.1, CD161c) and T cell (TCR) and express a conserved or invariant T cell receptor called V?#7284;J?#7288; in mice or Va24 in humans ...
Gwang Cheon Jang
doaj +1 more source