Immune evasion of the CD1d/NKT cell axis [PDF]
, 2018 Many reviews on the CD1d/NKT cell axis focus on the ability of CD1d-restricted NKT cells to serve as effector cells in a variety of disorders, be they infectious diseases, cancer or autoimmunity.
Brutkiewicz, Randy R. +2 more
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Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells
Nature Communications, 2020 Thymus is a unique environment hosting the development of many T cell subsets with distinct functions. Here the authors show that medullary thymic epithelial cells (mTEC) are functionally diverse, with LTβR signaling serving differential regulation of ...
Beth Lucas +9 more
doaj +1 more source
Tailored design of NKT-stimulatory glycolipids for polarization of immune responses. [PDF]
, 2017 Natural killer T (NKT) cell is a distinct population of T lymphocytes that can rapidly release massive amount of Th1 and Th2 cytokines upon the engagement of their T cell receptor with glycolipids presented by CD1d.
Huang, Jing-Rong +2 more
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CD1d expression and invariant NKT cell responses in herpesvirus infections
Frontiers in Immunology, 2015 Invariant natural killer T (iNKT) cells are a highly conserved subset of unconventional T lymphocytes that express a canonical, semi-invariant T cell receptor (TCR) and surface markers shared with the natural killer cell lineage.
Rusung eTan
doaj +1 more source
Natural killer cells in placentation and cancer: Implications for hypertension during pregnancy [PDF]
, 2017 Hypertension during pregnancy is the most common medical condition encountered during gestation. Despite this, knowledge of the mechanisms that underlie the disease and the development of new therapies are limited.
Cornelius, Denise C. +3 more
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New cell sources for CAR-based immunotherapy
Biomarker Research, 2023 Chimeric antigen receptor (CAR) T cell therapy, in which a patient’s own T lymphocytes are engineered to recognize and kill cancer cells, has achieved striking success in some hematological malignancies in preclinical and clinical trials, resulting in ...
Marzieh Mazinani, Fatemeh Rahbarizadeh
doaj +1 more source
Deficiency of invariant natural killer T cells in coeliac disease [PDF]
Gut, 2007 Immunoregulatory invariant natural killer (iNK) T cells rapidly produce interleukin (IL)-4 and other cytokines that suppress a Th1 response and are deficient in some autoimmune diseases.The aim of this study was to investigate any deficiency of iNK T cells in coeliac disease.Blood was collected from 86 subjects with coeliac disease and from 152 healthy
Grose, R., Cummins, A., Thompson, F.
openaire +3 more sources
A Potent CD1d-binding Glycolipid for iNKT-Cell-based Therapy Against Human Breast Cancer [PDF]
, 2019 Background/Aim: Invariant natural killer T-cells (iNKT) stimulated by CD1d-binding glycolipids have been shown to exert antitumor effects by a number of studies in a mouse model.
Brutkiewicz, Randy R. +3 more
core +1 more source
Immunoregulatory role of Jα281 T cells in aged mice developing lupus-like nephritis. [PDF]
, 2007 Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the emergence of autoreactive T cells. Humans and mice with SLE have reduced numbers of CD1d-restricted invariant natural killer T (iNKT) cells, suggesting a key role for these ...
Araki +41 more
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Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice. [PDF]
, 2016 Invariant Natural Killer T (iNKT) cells are a unique subset of T lymphocytes that have been implicated in both promoting and suppressing a multitude of immune responses. In mice, iNKT cells express T cell antigen receptors (TCRs) comprising a unique TCRα
Bedel, R. +7 more
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