The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells [PDF]
, 2018 Invariant natural killer T cells (iNKT cells) are innate-like lymphocytes that protect against infection, autoimmune disease and cancer. However, little is known about the epigenetic regulation of iNKT cell development.
Barnitz, R Anthony +16 more
core +1 more source
Glucosylceramide Synthase Is Involved in Development of Invariant Natural Killer T Cells
Frontiers in Immunology, 2017 Invariant natural killer T (iNKT) cells represent a unique population of CD1d-restricted T lymphocytes expressing an invariant T cell receptor encoded by Vα14-Jα18 and Vα24-Jα18 gene segments in mice and humans, respectively.
Zoran V. Popovic +7 more
doaj +1 more source
The Role of Autophagy in iNKT Cell Development
Frontiers in Immunology, 2018 CD1d-restricted invariant natural killer T (iNKT) cells are innate-like T cells that express an invariant T cell receptor (TCR) α-chain and recognize self and foreign glycolipid antigens.
Guan Yang, John P. Driver, Luc Van Kaer
doaj +1 more source
Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling [PDF]
, 2018 Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with
Andrews, Paul S. +8 more
core +5 more sources
Modulació del canvi d'isotip de les immunoglobulines per senyals del sistema immunitari innat [PDF]
, 2014 Els limfòcits B madurs emergeixen del moll de l'os i continuen diversificant el seu repertori genètic d'immunoglobulines a través de dos processos que depenen de la presència d'antigen, la hipermutació somàtica (SHM, per les seves sigles en anglès) i el ...
Cerutti, Andrea +2 more
core
Stages versus subsets: Invariant Natural Killer T cell lineage differentiation [PDF]
Cytokine, 2015 Invariant Natural Killer T (iNKT) cells represent a population of innate T lymphocytes which act as 'first-responders' to infection. While they have long been considered a versatile cell, capable of secretion of multiple cytokines upon activation, recent evidence now indicates that distinct lineages of iNKT cells with unique transcriptional and ...
Heather M, Buechel +2 more
openaire +2 more sources
Natural killer cells and natural killer T cells in Lyme arthritis [PDF]
, 2013 Introduction: Natural killer (NK) and natural killer T (NKT) cells provide a first line of defense against infection. However, these cells have not yet been examined in patients with Lyme arthritis, a late disease manifestation.
Drouin, Elise E +2 more
core +2 more sources
Modulatory Function of Invariant Natural Killer T Cells in Systemic Lupus Erythematosus
Clinical and Developmental Immunology, 2012 Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with complex immunological and clinical manifestations. Multiple organ failure in SLE can be caused by immune dysfunction and deposition of autoantibodies.
Yi-Ping Chuang +4 more
doaj +1 more source
The Role of Invariant Natural Killer T Cells in Dendritic Cell Licensing, Cross-Priming, and Memory CD8+ T Cell Generation [PDF]
, 2015 New vaccination strategies focus on achieving CD8+ T cell (CTL) immunity rather than on induction of protective antibody responses. While the requirement of CD4+ T (Th) cell help in dendritic cell (DC) activation and licensing, and in CTL memory ...
Catherine Gottschalk +2 more
core +2 more sources
Experimental Hematology & OncologyOver the past few years, dual-targeted chimeric antigen receptor (CAR) T-cell therapy has been employed in the management of hematological malignancies to mitigate treatment failure, particularly in cases of antigen escape.
Jingyi Yang +4 more
doaj +1 more source