Results 91 to 100 of about 15,260 (267)
A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity
Advanced Science, EarlyView.This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu +16 more
wiley +1 more source
Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis
, 2009 Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis Background: The role of cytotoxicity of NKT-cells in the skin is not defined. There are two prototypic skin diseases in which epidermal Keratinocytes (KC) over-express CD1d, a
Balato, Anna
core
, 2009 Supplementary Data from Invariant Natural Killer T Cells Regulate Breast Cancer Response to Radiation and CTLA-4 ...
Karsten A. Pilones (14919239) +5 more
core +1 more source
Experimental Hematology & OncologyOver the past few years, dual-targeted chimeric antigen receptor (CAR) T-cell therapy has been employed in the management of hematological malignancies to mitigate treatment failure, particularly in cases of antigen escape.
Jingyi Yang +4 more
doaj +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
, 2023 Jia Guo,1 Xuli Bao,1 Fuquan Liu,2 Jiang Guo,3 Yifan Wu,2 Fang Xiong,1 Jun Lu1 1Hepatology and Cancer Biotherapy Ward, Beijing YouAn Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Interventional Therapy, Beijing ...
Guo J, Bao X, Lu J, Xiong F, Liu F, Wu Y
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Development of Unconventional T Cells Controlled by MicroRNA
Frontiers in Immunology, 2019 Post-transcriptional gene regulation through microRNA (miRNA) has emerged as a major control mechanism of multiple biological processes, including development and function of T cells. T cells are vital components of the immune system, with conventional T
Samantha J. Winter, Andreas Krueger
doaj +1 more source
Enhancing Neuroblastoma Immunotherapies by Engaging iNKT and NK Cells
Frontiers in Immunology, 2020 Neuroblastoma (NB) is the most common extracranial solid tumor in children and, in the high-risk group, has a 5-year mortality rate of ~50%. The high mortality rate and significant treatment-related morbidities associated with current standard of care ...
Kevin O. McNerney +4 more
doaj +1 more source
Advanced Science, EarlyView.This study presents a 3D embedded bioprinting platform that recapitulates key stromal features of the tumor microenvironment using fibroblasts and lung‐derived ECM. The model enables functional assessment of CAR‐NK cells and provides a versatile tool to support the development of next‐generation immunotherapeutic strategies against solid tumors ...
Dahong Kim +10 more
wiley +1 more source
Thio-isoglobotrihexosylceramide, an Agonist for Activating Invariant Natural Killer T Cells
, 2016 Thio-isoglobotrihexosylceramide (S-iGb3) might be resistant to α-galactosidases in antigen-presenting cells and have a longer retaining time in the lysosome before being loaded to CD1d.
Chengwen Liu (2518702) +6 more
core +1 more source