Results 81 to 90 of about 75,921 (210)

Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure

Nature Communications, 2021
Invariant natural killer T cells are known to be composed of a number of phenotypic and functionally distinct populations. Here the authors use transcriptomic and epigenomic analysis to further characterize the peripheral iNKT compartment before and ...
Mallory Paynich Murray, Isaac Engel, Grégory Seumois, Sara Herrera-De la Mata, Sandy Lucette Rosales, Ashu Sethi, Ashmitaa Logandha Ramamoorthy Premlal, Goo-Young Seo, Jason Greenbaum, Pandurangan Vijayanand, James P. Scott-Browne, Mitchell Kronenberg   +11 more
doaj   +1 more source

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]

, 2019
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence, Keenan, Bridget P, Kelley, Robin K   +2 more
core   +2 more sources

Invariant Natural Killer T Cells As Suppressors of Graft-versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplantation

Frontiers in Immunology, 2017
Invariant natural killer T (iNKT) cells serve as a bridge between innate and adaptive immunity and have been shown to play an important role in immune regulation, defense against pathogens, and cancer immunity.
M. Mavers, Kristina Maas-Bauer, R. Negrin   +2 more
semanticscholar   +1 more source

Characterization of human invariant natural killer T cells expressing FoxP3 [PDF]

International Immunology, 2011
Abstract Recently described forkhead box protein 3 (FoxP3) transcription factor is a key molecule in CD4+ CD25hi+ T-cell characterization. Invariant NK T (iNKT) cells are also characterized as regulatory cells modulating the immune response by rapidly producing Th1 and Th2 cytokines.
Péter, Engelmann, Klára, Farkas, János, Kis, Geoffrey, Richman, Zhaoyun, Zhang, Chong Wee, Liew, Maciej, Borowiec, Monika A, Niewczas, Heyam, Jalahej, Tihamér, Orbán   +9 more
openaire   +2 more sources

A Fungal Glycosphingolipid Directly Activates Natural Killer T Cells and Rapidly Induces Airways Disease [PDF]

, 2014
Aspergillus fumigatusis a saprophytic fungus that is ubiquitous in the environment and commonly associated with allergic sensitization and severe asthma in humans. Although A.
Albacker, Lee A., Chang, Ya-Jen, Chaudhary, Vinod, Chuang, Ya-Ting, DeKruyff, Rosemarie H., Kim, Hye Young, Pichavant, Muriel, Savage, Paul B., Umetsu, Dale T.   +8 more
core   +1 more source

Unique invariant natural killer T cells promote intestinal polyps by suppressing TH1 immunity and promoting regulatory T cells

Mucosal Immunology, 2017
CD1d-restricted invariant natural killer T (iNKT) cells are known as potent early regulatory cells of immune responses. Besides the established roles in the regulation of inflammation and autoimmune disease, studies have shown that iNKT cells have ...
Ying Wang, S. Sedimbi, L. Löfbom, A. K. Singh, S. Porcelli, S. Cardell   +5 more
semanticscholar   +1 more source

Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia [PDF]

, 2014
SignificanceInvariant natural killer T cells (iNKT) have been found primarily patrolling inside blood vessels in the liver, where they respond to bacterial glycolipids presented by CD1d on liver macrophages. We show joint iNKT cells are localized outside
A. Marques, A. Salman-Dilgimen, Ajuebor, Auffray, Baba, Barbour, Bendelac, C. H. Mody, C. H. Y. Wong, Faunce, G. Chaconas, Geissmann, Hickey, Katagiri, Kawabata, Kawano, Kobayashi, Kronenberg, Kuylenstierna, Lee, M.-J. Sanz, Ma, Mattner, Moriarty, Norman, Oosting, P. Kubes, P.-O. Hardy, R. Krawetz, Steere, STEERE, T. J. Moriarty, van Gisbergen, W.-Y. Lee   +33 more
core   +1 more source

Altered Peripheral Invariant Natural Killer T Cells in Atopic Dermatitis [PDF]

Journal of Clinical Immunology, 2011
Conflicting data exist on the number of invariant NKT (iNKT) cells in atopic dermatitis (AD); furthermore, no data have been published on their functional capacity.The frequency and number of circulating CD3+6B11+ iNKT cells and their CD4+ and CD4- subpopulations were evaluated in peripheral blood obtained from 41 patients with AD by four-color flow ...
Gyimesi, Edit, Nagy, Georgina, Remenyik, Éva, Sipka, Sandor, Zeher, Margit, Bíró, Tamás, Szegedi, Andrea   +6 more
openaire   +2 more sources

MAIT cells regulate NK cell-mediated tumor immunity

Nature Communications, 2021
Mucosal-associated invariant T (MAIT) cells facilitate anti-microbial responses, but their functions in cancer protection is unclear. Here the authors show that activated MAIT cells induce an IFN-γ transcriptome in natural killer (NK) cells and enhance ...
Emma V. Petley, Hui-Fern Koay, Melissa A. Henderson, Kevin Sek, Kirsten L. Todd, Simon P. Keam, Junyun Lai, Imran G. House, Jasmine Li, Magnus Zethoven, Amanda X. Y. Chen, Amanda J. Oliver, Jessica Michie, Andrew J. Freeman, Lauren Giuffrida, Jack D. Chan, Angela Pizzolla, Jeffrey Y. W. Mak, Timothy R. McCulloch, Fernando Souza-Fonseca-Guimaraes, Conor J. Kearney, Rosemary Millen, Robert G. Ramsay, Nicholas D. Huntington, James McCluskey, Jane Oliaro, David P. Fairlie, Paul J. Neeson, Dale I. Godfrey, Paul A. Beavis, Phillip K. Darcy   +30 more
doaj   +1 more source

TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells [PDF]

, 2017
TET proteins oxidize 5-methylcytosine in DNA to 5-hydroxymethylcytosine and other oxidation products. We found that simultaneous deletion of Tet2 and Tet3 in mouse CD4+CD8+ double-positive thymocytes resulted in dysregulated development and proliferation
A Bendelac, A Tsagaratou, A Tsagaratou, AC Carpenter, Ageliki Tsagaratou, Anjana Rao, AP Heinen, D Fonseca-Pereira, D Lara-Astiaso, DR Winter, E Wolf, Edahí González-Avalos, Ellen V Rothenberg, G Vahedi, GL Stritesky, Harri Lähdesmäki, I Engel, I Engel, IM Djuretic, J An, James P Scott-Browne, JD Buenrostro, JM Karo, JM Matthews, K Ichiyama, KA Hogquist, KD Rasmussen, KR Kieffer-Kwon, L Laurent, Lukas Chavez, M Dose, M Jeong, M Ko, M Ko, M Ko, M Tahiliani, MA Yui, MJ Townsend, MN Uddin, MW Dobenecker, PP Lee, R Mathew, RG Ramsay, RM Pereira, S Ito, S Picelli, S Yu, Sini Rautio, Susan Togher, T Carr, TP Gu, V Sasidharan Nair, WA Pastor, WA Pastor, William A Pastor, X Yue, Y Huang, Y Huang, Y Huang, Y Shen, YF He, YJ Lee, YJ Lee, YJ Lee, ZD Smith   +64 more
core   +2 more sources