Results 1 to 10 of about 15,268 (219)

Regeneration of invariant natural killer T (iNKT) cells: application of iPSC technology for iNKT cell-targeted tumor immunotherapy [PDF]

Inflammation and Regeneration, 2023
Invariant natural killer T (iNKT) cells are a subset of innate-like T cells restricted by a major histocompatibility complex (MHC) class I-like molecule, CD1d.
Takahiro Aoki, Shinichiro Motohashi, Haruhiko Koseki   +2 more
doaj   +2 more sources

Melanoma causes phenotypic modulations and metabolic switches of iNKT cells influencing clinical outcomes [PDF]

Frontiers in Immunology
IntroductionInvariant NKT (iNKT) cells are crucial effectors in cancer immunosurveillance, due to their immunomodulatory potential through a broad range of effector and regulatory functions.
Emmanuelle Degeorges, Emmanuelle Degeorges, Stéphane Mouret, Pauline Girard, Pauline Girard, Camille Niveau, Camille Niveau, Mélanie Cettour-Cave, Mélanie Cettour-Cave, Eleonora Sosa Cuevas, Eleonora Sosa Cuevas, Florence De Fraipont, Julie Charles, Philippe Saas, Philippe Saas, Caroline Aspord, Caroline Aspord   +16 more
doaj   +2 more sources

Bimodal CD40/Fas-Dependent Crosstalk between iNKT Cells and Tumor-Associated Macrophages Impairs Prostate Cancer Progression

Cell Reports, 2018
Summary: Heterotypic cellular and molecular interactions in the tumor microenvironment (TME) control cancer progression. Here, we show that CD1d-restricted invariant natural killer (iNKT) cells control prostate cancer (PCa) progression by sculpting the ...
Filippo Cortesi, Gloria Delfanti, Andrea Grilli, Arianna Calcinotto, Francesca Gorini, Ferdinando Pucci, Roberta Lucianò, Matteo Grioni, Alessandra Recchia, Fabio Benigni, Alberto Briganti, Andrea Salonia, Michele De Palma, Silvio Bicciato, Claudio Doglioni, Matteo Bellone, Giulia Casorati, Paolo Dellabona   +17 more
doaj   +3 more sources

Over-activation of iNKT cells aggravate lung injury in bronchopulmonary dysplasia mice [PDF]

Redox Biology
Bronchopulmonary dysplasia (BPD) is a severe lung disease in preterm infants, the abnormal proliferate and differentiate ability of type II epithelial cells (AEC II) is the key to the pathological basis of BPD. Mechanisms regarding abnormal AEC II in BPD
Ming-Yan Wang, Meng-Xu Yi, Xing-Yu Mo, Shan-Jie Wei, Yu Qiao, Zheng Zhang, Zhao-Liang Su, Hong-Yan Lu   +7 more
doaj   +2 more sources

Single-cell transcriptomic profiling reveals diversity in human iNKT cells across hematologic tissues [PDF]

Cell Reports
Summary: Invariant natural killer T (iNKT) cells are evolutionarily conserved innate lymphocytes important for protection against pathogens, malignancies, and graft-versus-host disease, with potential for universal donor cellular therapies.
Reyka G. Jayasinghe, Derek Hollingsworth, Nathan C. Schedler, Emily Landy, Chaiyaporn Boonchalermvichian, Biki Gupta, Hao Yan, Jeanette Baker, Beruh Dejene, Kenneth I. Weinberg, Robert S. Negrin, Melissa Mavers   +11 more
doaj   +2 more sources

PD-1 checkpoint inhibition enhances the antilymphoma activity of CD19-CAR-iNKT cells that retain their ability to prevent alloreactivity [PDF]

Journal for ImmunoTherapy of Cancer
Background Relapse and graft-versus-host disease (GVHD) are the main causes of death after allogeneic hematopoietic cell transplantation (HCT). Preclinical murine models and clinical data suggest that invariant natural killer T (iNKT) cells prevent acute
Anita Schmitt, Brigitte Neuber, Michael Schmitt, Melanie Märklin, Boris Klimovich, Claudia Lengerke, Emmanuelle Moraes Ribeiro, Kathy-Ann Secker, Ana-Maria Nitulescu, Rebekka Schairer, Hildegard Keppeler, Anton Wesle, Hannes Schmid, Daniela Chmiest, Silvia Podavini, Fulya Korkmaz, Corina Schneidawind, Dominik Schneidawind   +17 more
doaj   +2 more sources

Aging unconventionally: γδ T cells, iNKT cells, and MAIT cells in aging. [PDF]

Semin Immunol, 2023
Kurioka A, Klenerman P.
europepmc   +2 more sources

Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy. [PDF]

Cell Rep Med, 2021
Li YR, Zhou Y, Kim YJ, Zhu Y, Ma F, Yu J, Wang YC, Chen X, Li Z, Zeng S, Wang X, Lee D, Ku J, Tsao T, Hardoy C, Huang J, Cheng D, Montel-Hagen A, Seet CS, Crooks GM, Larson SM, Sasine JP, Wang X, Pellegrini M, Ribas A, Kohn DB, Witte O, Wang P, Yang L.   +28 more
europepmc   +2 more sources

Distinct and overlapping effector functions of expanded human CD4+, CD8α+ and CD4-CD8α- invariant natural killer T cells. [PDF]

PLoS ONE, 2011
CD1d-restricted invariant natural killer T (iNKT) cells have diverse immune stimulatory/regulatory activities through their ability to release cytokines and to kill or transactivate other cells.
Vincent O'Reilly, Shijuan G Zeng, Gabriel Bricard, Ann Atzberger, Andrew E Hogan, John Jackson, Conleth Feighery, Steven A Porcelli, Derek G Doherty   +8 more
doaj   +1 more source

Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice

Nature Communications, 2023
Adipose tissue invariant natural killer T (iNKT) cells are a crucial cell type for adipose tissue homeostasis in obese animals. However, heterogeneity of adipose iNKT cells and their function in adipocyte turnover are not thoroughly understood.
Sang Mun Han, Eun Seo Park, Jeu Park, Hahn Nahmgoong, Yoon Ha Choi, Jiyoung Oh, Kyung Min Yim, Won Taek Lee, Yun Kyung Lee, Yong Geun Jeon, Kyung Cheul Shin, Jin Young Huh, Sung Hee Choi, Jiyoung Park, Jong Kyoung Kim, Jae Bum Kim   +15 more
doaj   +1 more source